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CPAP vs NIPPV for Premature Infants
N/A
Recruiting
Research Sponsored by Sunnybrook Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group
Summary
This trial compares two methods of providing breathing support to premature babies: CPAP and NIPPV. CPAP delivers constant pressure to the baby's lungs to help with breathing, while NIPPV delivers
Who is the study for?
This trial is for very low birth weight preterm infants who need breathing support due to immature lungs. It's not suitable for those with certain medical conditions that the study doesn't specify.
What is being tested?
The study tests how different non-invasive breathing supports affect diaphragm activity in premature babies. It compares traditional CPAP, NIPPV, and high-pressure CPAP to see which helps their tiny lungs best.
What are the potential side effects?
While specific side effects are not detailed, interventions like CPAP and NIPPV may cause nasal irritation or discomfort in some infants.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
6Treatment groups
Experimental Treatment
Group I: Traditional CPAP, then high CPAP, then NIPPVExperimental Treatment1 Intervention
The participant will stay for 2 hours on Traditional CPAP, then 2 hours on high CPAP, then 2 hours on NIPPV. The investigators will continue to record the Edi signals during the 3 methods.
Group II: Traditional CPAP, then NIPPV, then high CPAP.Experimental Treatment1 Intervention
The participant will stay for 2 hours on Traditional CPAP, then 2 hours on NIPPV, then 2 hours on high CPAP. The investigators will continue to record the Edi signals during the 3 methods.
Group III: NIPPV, then traditional CPAP, then high CPAPExperimental Treatment1 Intervention
The participant will stay for 2 hours on NIPPV, then 2 hours on traditional CPAP, then 2 hours on high CPAP. The investigators will continue to record the Edi signals during the 3 methods.
Group IV: NIPPV, then high CPAP, then traditional CPAP.Experimental Treatment1 Intervention
The participant will stay for 2 hours on NIPPV, then 2 hours on high CPAP, then 2 hours on traditional CPAP. The investigators will continue to record the Edi signals during the 3 methods.
Group V: High CPAP, then traditional CPAP, then NIPPV.Experimental Treatment1 Intervention
The participant will stay for 2 hours on High CPAP, then 2 hours on traditional CPAP, then 2 hours on NIPPV. The investigators will continue to record the Edi signals during the 3 methods.
Group VI: High CPAP, then NIPPV, then traditional CPAP.Experimental Treatment1 Intervention
The participant will stay for 2 hours on High CPAP, then 2 hours on NIPPV, then 2 hours on traditional CPAP. The investigators will continue to record the Edi signals during the 3 methods.
Find a Location
Who is running the clinical trial?
Sunnybrook Health Sciences CentreLead Sponsor
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