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Auditory Stimulation for Schizophrenia

N/A

Recruiting

Led By Dara Manoach, PhD

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

18-50 years of age

Male and female schizophrenia outpatients

Timeline

Screening 3 weeks

Treatment Varies

Follow Up placebo and auditory stimulation naps will be approximately one week apart

Summary

This trial will test whether playing quiet sounds during sleep can normalize brain activity and improve memory in patients with schizophrenia.

Who is the study for?

This trial is for English-speaking men and women aged 18-50 who have been diagnosed with schizophrenia. Participants must be outpatients, meaning they aren't currently in the hospital, and able to give informed consent to participate.

What is being tested?

The study is examining if playing quiet sounds during sleep (auditory stimulation) can help normalize brain activity and improve memory in people with schizophrenia compared to a placebo (no sound).

What are the potential side effects?

Since this trial involves auditory stimulation which is non-invasive, side effects are expected to be minimal but may include disturbances in sleep patterns or discomfort due to wearing headphones during sleep.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 50 years old.

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I am an outpatient being treated for schizophrenia.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ placebo and auditory stimulation naps will be approximately one week apart

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~placebo and auditory stimulation naps will be approximately one week apart

This trial's timeline: 3 weeks for screening, Varies for treatment, and placebo and auditory stimulation naps will be approximately one week apart for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Differences in slow-oscillation spindle coupling

Secondary study objectives

Differences in sleep spindles

Differences in sleep-dependent consolidation of motor procedural memory

Differences in slow oscillations

Trial Design

2Treatment groups

Experimental Treatment

Group I: SchizophreniaExperimental Treatment2 Interventions

Adult outpatients with a diagnosis of schizophrenia.

Group II: Healthy ControlsExperimental Treatment2 Interventions

Adult participants screened to exclude a personal history of mental illness, family history of schizophrenia spectrum disorder, and psychoactive medication use.

0 / 2Eligibility criteria met