Vagal Nerve Stimulation to Reduce Inflammation and Hyperadrenergia
Trial Summary
What is the purpose of this trial?
The purpose of this research device study is to learn more about the autonomic nervous system. This system uses nerves to send information from the brain to the rest of the body by electrical signaling and has two divisions, the sympathetic and the parasympathetic branches. It has been thought that electrical stimulation devices could be used to restore balance to the nervous system. Because most of the imbalance seems to happen due to too much sympathetic activity, the investigator plans to focus on the parasympathetic branch. Specifically, the investigator hopes to restore balance by targeting the vagus nerve, which is the main communicator of the parasympathetic branch. The study will examine whether the investigator can decrease sympathetic activity and chronic inflammation by increasing parasympathetic activity. This is a device study that will examine the use of non-invasive vagal nerve stimulation to attenuate inflammatory stress and sympathetic hyperactivity in persons with Spinal Cord Injury and Non-Disabled Controls.
Research Team
Mark S Nash, Ph.D.
Principal Investigator
University of Miami
Eligibility Criteria
Inclusion Criteria
Treatment Details
Interventions
- InTENsity MicroCombo (Vagal Nerve Stimulation)
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Who Is Running the Clinical Trial?
University of Miami
Lead Sponsor
Sylvia Daunert
University of Miami
Chief Executive Officer since 2011
PhD in Biochemistry and Molecular Biology, University of Kentucky
Bahar Motlagh
University of Miami
Chief Medical Officer since 2021
PhD in Biomedical Engineering, Ecole Polytechnique Montreal