Thrombectomy for Stroke

(DUSK Trial)

Overseen by Raul G Nogueira, MD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Raul Nogueira

No Placebo Group

Trial Summary

What is the purpose of this trial?

A phase III, randomized, multi-center, investigational, open label clinical trial that will examine whether treatment with endovascular thrombectomy is superior to standard medical therapy alone in patients who suffer a Distal Medium Vessel Occlusion Ischemic Stroke within 12 hours from time last seen well

Research Team

Raul G Nogueira, MD

Principal Investigator

University of Pittsburgh

Eligibility Criteria

This trial is for adults over 18 with acute ischemic stroke from a blockage in medium-sized vessels, who can't have or didn't improve with standard clot-dissolving treatment. They must be treatable within 12 hours of symptoms starting and not have severe pre-stroke disabilities. Excluded are those improving rapidly, with other significant brain damage, terminal illnesses, certain blood conditions, drug/alcohol dependency affecting study adherence, known pregnancy or incarceration.

Inclusion Criteria

I have a blockage in a specific small blood vessel in my brain that can be treated with a procedure.

Informed consent obtained from patient or acceptable patient surrogate

You had a stroke that left you with significant difficulties in speaking, seeing, or moving your body.

Exclusion Criteria

You have a large area of damage in your brain from a stroke.

Prisoner or incarceration

Known pregnancy

Treatment Details

Interventions

• Endovascular Thrombectomy (Procedure)

Trial Overview The trial tests if physically removing the clot (endovascular thrombectomy) is better than just giving medicine for strokes caused by clots in medium-sized brain arteries. Participants will either receive this new procedure or stick to standard medical care without it.

Participant Groups

Group I: Endovascular Thrombectomy Experimental Treatment 1 Intervention

Endovascular thrombectomy in patients who suffer a distal medium vessel occlusion.

Group II: Standard of Care Treatment Active Control 1 Intervention

Standard medical management in patients who suffer a distal medium vessel occlusion

Who Is Running the Clinical Trial?

Raul Nogueira

Lead Sponsor

Trials

1

Recruited

560+

Stryker Neurovascular

Industry Sponsor

Trials

36

Recruited

12,800+

Brainstorme Imaging Core Lab Inc

Collaborator

Trials

1

Recruited

560+

Berry Consultants

Collaborator

Trials

16

Recruited

58,200+