Orchiectomy Techniques for Testicular Cancer

(PRESERVE Trial)

Overseen By Brian Hu, MD

Age: 18+

Sex: Male

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Loma Linda University

No Placebo Group

Trial Summary

What is the purpose of this trial?

The purpose of this study is to evaluate the difference in patient-reported postoperative outcomes between two standard-of-care surgical techniques for radical orchiectomy (inguinal orchiectomy versus external oblique fascia sparing orchiectomy) for treatment of patients with suspected testicular malignancy. The main questions it aims to answer are: 1. Does sparing the external oblique fascia during orchiectomy reduce pain after surgery? 2. Is there a difference in narcotic consumption after surgery? 3. Is there a difference in neuropathic pain after surgery? 4. Is there a difference in complications after surgery?

Eligibility Criteria

This trial is for men with suspected nonseminomatous or any type of testicular cancer who are candidates for radical orchiectomy. Specific eligibility criteria details were not provided, so interested individuals should inquire further to determine if they qualify.

Inclusion Criteria

Participants not currently using opiates for another reason

I have a testicular tumor and surgery to remove a testicle is planned.

I can take standard medications before and after surgery.

Exclusion Criteria

History of illicit substance abuse (including prior opioid abuse) except for marijuana

Opioid use within 1 month of study enrollment

I need surgery for a large testis mass that requires an incision bigger than 8 cm.

Treatment Details

Interventions

• Radical external oblique fascia sparing orchiectomy (Surgery)
• Radical inguinal orchiectomy (Surgery)

Trial Overview The study compares two surgical methods: the traditional inguinal orchiectomy and a technique that spares the external oblique fascia. It's randomized and single-blinded, focusing on patient-reported outcomes like postoperative pain, narcotic use, neuropathic pain, and complications.

Participant Groups

Group I: Radical inguinal orchiectomy Active Control 1 Intervention

Group II: Radical external oblique fascia sparing orchiectomy Active Control 1 Intervention

Who Is Running the Clinical Trial?

Loma Linda University

Lead Sponsor

Trials

322

Recruited

267,000+