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Timing of Breathing Tests for Patients on Ventilators

N/A
Waitlist Available
Led By JIE LI, PhD
Research Sponsored by Rush University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adults aged 21 years or older
Patients who have been on mechanical ventilation for more than 48 hours
Must not have
Patients intubated for surgical or interventional procedures
Patients with a tracheostomy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from enrollment to the end of study at 28 days
Awards & highlights

Summary

This trial aims to see how the timing of breathing tests affects recovery for ICU patients on ventilators. They will compare two timing strategies: one group will have the test early morning, while the other group

Who is the study for?
This trial is for adult ICU patients who are currently on mechanical ventilation. It's designed to see if the timing of a breathing test, which checks if they can breathe without help, affects their recovery.
What is being tested?
The study is testing whether conducting Spontaneous Breathing Trials (SBTs) early in the morning or later in the morning leads to better outcomes for patients needing ventilator support in the ICU.
What are the potential side effects?
Since this trial involves only changing the timing of an already routine procedure and not testing a new medication or device, there are no additional side effects expected beyond those typically associated with SBTs.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am 21 years old or older.
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I have been on a breathing machine for more than 2 days.
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I have completed at least one session of brief therapy.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I was intubated for a surgery or procedure.
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I have a tracheostomy.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from enrollment to the end of study at 28 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and from enrollment to the end of study at 28 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
mechanical ventilation duration
Secondary study objectives
Duration Between SBT Success and Extubation
ICU and Hospital Lengths of Stay
ICU and Hospital Mortality
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Later morning timing of spontaneous breathing trialExperimental Treatment1 Intervention
Later Morning Group: Patients in this group will have their SBTs scheduled between 8:00 AM and 9:00 AM, closer to the time of day shift rounds.
Group II: Early morning timing of spontaneous breathing trialActive Control1 Intervention
Early Morning Group: Patients in this group will undergo their SBTs between 4:00 AM and 5:00 AM, following the traditional early morning schedule used in some ICUs.

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Who is running the clinical trial?

Rush University Medical CenterLead Sponsor
431 Previous Clinical Trials
158,053 Total Patients Enrolled
JIE LI, PhDPrincipal InvestigatorRush University
1 Previous Clinical Trials
26 Total Patients Enrolled
~232 spots leftby Dec 2025
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