Trial Summary
What is the purpose of this trial?
This trial is testing whether adding vibrations to standard recovery exercises can help people who have had ACL surgery. The vibrations aim to improve muscle function and movement, potentially reducing the risk of further knee problems.
Do I have to stop taking my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications. Please consult with the trial coordinators for more information.
What data supports the idea that Vibration Therapy for Osteoarthritis after ACL Injury is an effective treatment?
The available research shows that Vibration Therapy, including both Whole Body Vibration (WBV) and Local Muscle Vibration (LMV), can be effective for people recovering from ACL injuries. One study found that WBV improved the ability to quickly generate knee strength, which is important for physical function. Another study showed that LMV helped reduce the force on the knee when walking, which can be beneficial for joint health. Additionally, a study on Local Body Vibration (LBV) found that it reduced pain and improved leg strength and movement range. These findings suggest that Vibration Therapy can help improve muscle function and reduce pain, making it a promising treatment option for those with osteoarthritis after an ACL injury.12345
What safety data exists for vibration therapy in treating osteoarthritis after ACL injury?
The available research suggests that vibration therapy, including whole-body vibration (WBV) and local muscle vibration (LMV), is being explored for its potential benefits in improving gait biomechanics and muscle function following ACL injury. While specific safety data is not detailed in the provided studies, the research indicates that vibration therapy is being considered as a rehabilitative tool with potential benefits for joint health and muscle performance. The systematic review on WBV in aging adults discusses potential precautions and safety concerns, suggesting that safety is a consideration in the application of this therapy. However, more specific safety data related to osteoarthritis after ACL injury would require further investigation or consultation with clinical trial data.23678
Is Standard ACL Rehabilitation with Vibration Therapy a promising treatment for osteoarthritis after ACL injury?
Eligibility Criteria
This trial is for individuals aged 16-35 who've had a specific knee surgery (ACLR) using their own tissue. They must not have had previous ACL injuries, other knee surgeries, recent leg injuries besides the primary ACL injury, diagnosed arthritis in lower joints, neurological disorders, MRI contraindications like metal implants or severe claustrophobia, or be pregnant.Inclusion Criteria
You are between 16 and 35 years old.
You had surgery to fix your ACL using a specific type of tendon from your own body.
Exclusion Criteria
You have previously injured your ACL or had surgery to repair it.
You have had surgery on your knee in the past.
You need to have surgery on more than one ligament at the same time as your ACL surgery.
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Treatment Details
Interventions
- Local Muscle Vibration (Behavioural Intervention)
- Standard ACL Rehabilitation (Behavioural Intervention)
- Whole Body Vibration (Behavioural Intervention)
Trial OverviewThe study tests if adding vibration to standard rehab after ACL surgery can improve outcomes. Participants are randomly placed into three groups: one with regular rehab exercises; another adds whole body vibration; and the last uses local muscle vibration. Their muscle function, gait, joint health via MRI and risk of re-injury will be monitored over a year.
Participant Groups
3Treatment groups
Experimental Treatment
Active Control
Group I: Whole Body VibrationExperimental Treatment1 Intervention
Patients will perform standard rehabilitation for the first month post-ACLR. At 1 month they will continue with standard rehabilitation, but will also be exposed to whole body vibration at the beginning of each session prior to rehabilitation exercises in an effort to enhance their efficacy.
Group II: Local Muscle VibrationExperimental Treatment1 Intervention
Patients will perform standard rehabilitation for the first month post-ACLR. At 1 month they will continue with standard rehabilitation, but will also be exposed to local muscle vibration at the beginning of each session prior to rehabilitation exercises in an effort to enhance their efficacy.
Group III: Standard ACL RehabilitationActive Control1 Intervention
Patients will complete a 20-week supervised, progressive rehabilitation protocol directed by physical therapists at 1 of 3 participating clinics. While the specific rehabilitation exercises and techniques used for a given patient may vary depending on clinician preference/experience and patient responsiveness and progress, the general rehabilitation protocol will be standardized and follow current best practices emphasizing restoration of early weight bearing, range of motion, quadriceps function, balance, and neuromuscular control consistent with the Multicenter Orthopaedics Outcomes Network (MOON) rehabilitation protocol.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Womack Army Medical CenterChapel Hill, NC
MOTION Science InstituteChapel Hill, NC
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Who Is Running the Clinical Trial?
University of North Carolina, Chapel HillLead Sponsor
Womack Army Medical CenterCollaborator
References
The effect of early whole-body vibration therapy on neuromuscular control after anterior cruciate ligament reconstruction: a randomized controlled trial. [2022]Despite rehabilitation training, deficiency in knee joint position sense, muscular performance, postural control, and functional ability is common after anterior cruciate ligament reconstruction (ACLR). Whole-body vibration therapy (WBVT), which is initiated from 3 months postoperatively, has proven benefits. However, the effect of earlier WBVT is unknown.
Effect of whole body vibration frequency on neuromuscular activity in ACL-deficient and healthy males. [2018]Whole-body vibration (WBV) has been shown to enhance muscle activity via reflex pathways, thus having the potential to contrast muscle weakness in individuals with rupture of the anterior cruciate ligament (ACL). The present study aimed to compare the magnitude of neuromuscular activation during WBV over a frequency spectrum from 20 to 45 Hz between ACL-deficient and healthy individuals. Fifteen males aged 28±4 with ACL rupture and 15 age-matched healthy males were recruited. Root mean square (RMS) of the surface electromyogram from the vastus lateralis in both limbs was computed during WBV in a static half-squat position at 20, 25, 30, 35, 40 and 45 Hz, and normalized to the RMS while maintaining the half-squat position without vibration. The RMS of the vastus lateralis in the ACL-deficient limb was significantly greater than in the contralateral limb at 25, 30, 35 and 40 Hz (P
Vibration improves gait biomechanics linked to posttraumatic knee osteoarthritis following anterior cruciate ligament injury. [2021]Anterior cruciate ligament reconstruction (ACLR) incurs a high risk of posttraumatic knee osteoarthritis (PTOA). Aberrant gait biomechanics contribute to PTOA and are attributable in part to quadriceps dysfunction. Vibration improves quadriceps function following ACLR, but its effects on gait biomechanics are unknown. The purpose of this study was to evaluate the effects of whole-body vibration (WBV) and local muscle vibration (LMV) on gait biomechanics in individuals with ACLR. Seventy-five volunteers (time since ACLR 27 ± 16 months) were randomized to WBV, LMV, or Control interventions. Walking biomechanics were assessed prior to and following a single exposure to the interventions. Outcomes included pre-post change scores in the ACLR limb for the peak vertical ground reaction force (vGRF) and its loading rate, peak internal knee extension (KEM) and abduction moments, and peak knee flexion and varus angles. LMV produced a significant decrease in the vGRF loading rate (-3.6 BW/s) that was greater than the changes in the WBV (-0.3 BW/s) and Control (0.5 BW/s) groups. Additionally, WBV produced an increase in the peak KEM (0.27% BW × Ht) that was greater than the change in the Control group (-0.17% BW × Ht) but not the LMV group (0.01% BW × Ht). Lower KEM and greater loading rates have been linked to declines in joint health following ACLR. WBV acutely increased the peak KEM and LMV decreased loading rates. These data suggest that vibration has the potential to mitigate aberrant gait biomechanics, and may represent an effective approach for reducing PTOA risk following ACLR.
Whole-Body Vibration Improves Early Rate of Torque Development in Individuals With Anterior Cruciate Ligament Reconstruction. [2018]Pamukoff, DN, Pietrosimone, B, Ryan, ED, Lee, DR, Brown, LE, and Blackburn, JT. Whole body vibration improves early rate of torque development in individuals with anterior cruciate ligament reconstruction. J Strength Cond Res 31(11): 2992-3000, 2017-The purpose of this study was to compare the effect of whole-body vibration (WBV) and local muscle vibration (LMV) on early and late quadriceps rate of torque development (RTD), and electromechanical delay (EMD) in individuals with anterior cruciate ligament reconstruction (ACLR). Twenty individuals with ACLR were recruited for this study. Participants performed isometric squats while being exposed to WBV, LMV, or no vibration (control) in a randomized order during separate visits. Early and late quadriceps RTD and EMD were assessed during a maximal voluntary isometric knee extension before and immediately after WBV, LMV, or control. There was a significant condition by time interaction for early RTD (p = 0.045) but not for late RTD (p = 0.11) or EMD of the vastus medialis (p = 0.15), vastus lateralis (p = 0.17), or rectus femoris (p = 0.39). Post hoc analyses indicated a significant increase in early RTD after WBV (+5.59 N·m·s·kg; 95% confidence interval, 1.47-12.72; p = 0.007). No differences were observed in the LMV or control conditions, and no difference was observed between conditions at posttest. The ability to rapidly produce knee extension torque is essential to physical function, and WBV may be appropriate to aid in the restoration of RTD after ACLR.
Rehabilitation Program Combined with Local Vibroacoustics Improves Psychophysiological Conditions in Patients with ACL Reconstruction. [2020]Background and objective: This study investigated the therapeutic effect of applying local body vibration (LBV) with built-in vibroacoustic sound on patients who had an anterior cruciate ligament (ACL) reconstruction. Materials and Methods: Twenty-four participants were randomly classified into a LBV group (LBVG; n = 11) or a non-LBV group (nLBVG; n = 13). Both groups received the same program; however, the LBVG received LBV. Psychological measures included pain, anxiety, and symptoms; physiological measures included systolic blood pressure (SBP), diastolic blood pressure, heart rate (HR), breathing rate (BR), sympathetic activation (SA), parasympathetic activation (PSA), range of motion (ROM), and isokinetic muscle strength at Weeks 0, 4, and 8. Results: Among the psychophysiological variables, pain, anxiety, symptoms, SBP, BR, and SA were significantly reduced in both groups, whereas HR, PSA, isokinetic peak torque (PT) of the knee joint, and ROM were significantly improved only in the LBVG. Comparing both groups, a significant difference appeared in pain, symptom, SA, PSA, isokinetic PT, and ROM at Weeks 4 and 8. Conclusions: The results indicate that the LBV intervention mitigated the participants' pain and symptoms and improved their leg strength and ROM, thus highlighting its effectiveness.
Effects of 6-week whole body vibration training on the reflex response of the ankle muscles: a randomized controlled trial. [2021]The ligament sprain of the lateral ankle is the most frequent injury that occurs when participating in sports. Whole body vibration (WBV) is a training method that has been recently introduced as a rehabilitative tool for treatment of athletes. It has been hypothesized that the transmission of mechanical oscillations from the vibrating platform may lead to physiological changes in muscle spindles, joint mechanoreceptors, as well as improve balance.
The effects of whole-body vibration training in aging adults: a systematic review. [2019]Whole-body vibration (WBV), has become increasingly popular as a form of exercise training. WBV involves the application of a vibratory stimulus to the entire body as opposed to local stimulation of specific muscle groups. The purpose of this review was to assess the evidence concerning the effectiveness of WBV training studies on bone density, muscle performance, balance, and functional mobility in older adults and to discuss potential precautions, safety concerns, and practical clinical considerations of WBV.
Reporting whole-body vibration intervention studies: recommendations of the International Society of Musculoskeletal and Neuronal Interactions. [2022]Whole-body vibration (WBV) is receiving increasing interest as a therapeutic modality to improve neuromuscular performance or to increase bone mass or density. In order to help improve the quality of reports about WBV treatment studies, the International Society of Musculoskeletal and Neuronal Interactions (ISMNI) invited experts in the field to provide suggestions on how the intervention should be described in such reports. The recommendations are presented here.
The effectiveness of vibration therapy for muscle peak torque and postural control in individuals with anterior cruciate ligament reconstruction: a systematic review and meta-analysis of clinical trials. [2021]This study aimed to review and summarize the existing evidence on the effectiveness of vibration therapy (VT) in comparison with conventional rehabilitation in anterior cruciate ligament (ACL)-reconstructed patients considering muscle peak torque and postural control.
The Effects of Whole Body Vibration on the Limits of Stability in Adults With Subacute Ankle Injury. [2023]Limited research exists on the effects of both high and low frequency whole body vibration (WBV) on individuals with subacute lateral ankle sprains.
Does the Addition of Whole-Body Vibration Training Improve Postural Stability and Lower Limb Strength During Rehabilitation Following Anterior Cruciate Ligament Reconstruction: A Systematic Review With Meta-analysis. [2023]To investigate whether the addition of whole-body vibration therapy to standard rehabilitation improves postural stability and lower limb strength following anterior cruciate ligament (ACL) reconstruction.