What is the mechanism of action of this treatment?

Common treatments for dry mouth, such as moisturizing agents and saliva substitutes, work by hydrating the oral cavity and providing a protective coating to reduce dryness. These treatments often contain ingredients like glycerin or hyaluronic acid, which attract and retain moisture. Additionally, some products include antimicrobial agents or flavoring to neutralize and mask bad breath. This is crucial for dry mouth patients as it not only alleviates discomfort and difficulty in speaking or swallowing but also helps maintain oral hygiene and reduces the risk of dental issues and infections.

What side effects are associated with this type of intervention?

Common treatments for dry mouth include moisturizing sprays, mouthrinses, and oral gels. Moisturizing sprays like Biotène can provide temporary relief but may cause mild side effects such as altered taste or a slight burning sensation. Mouthrinses containing chlorhexidine or cetylpyridinium chloride can help reduce oral bacteria and bad breath but may lead to tooth staining, altered taste, and, in some cases, mucosal irritation. Oral gels and serums, such as those similar to Crest Daily Whitening Serum, aim to alleviate dryness and mask odors; potential side effects include mild irritation, altered taste, and, rarely, allergic reactions.

What prior FDA approvals exist?

FDA-approved treatments for dry mouth include saliva substitutes and stimulants. Saliva substitutes, such as Biotene and Oasis, are designed to moisturize the oral cavity and provide relief from dryness. These products often contain ingredients like glycerin and xylitol to mimic natural saliva and maintain oral moisture. Additionally, medications like pilocarpine (Salagen) and cevimeline (Evoxac) are approved to stimulate saliva production in patients with conditions like Sjögren's syndrome. These treatments help alleviate dryness and can also reduce bad breath by maintaining oral moisture.

What other types of research exist?

Promising alternatives to Crest Daily Whitening Serum for dry mouth and bad breath include: 1) Biotène Oralbalance Gel, which provides long-lasting moisture and relief from dry mouth symptoms. 2) XyliMelts Discs, which adhere to the gums and release xylitol to stimulate saliva production and freshen breath. 3) TheraBreath Dry Mouth Lozenges, which contain natural ingredients to stimulate saliva flow and neutralize odors. These products are designed to alleviate dryness and improve oral comfort, making them suitable alternatives for dry mouth patients.

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Whitening Serum for Dry Mouth and Bad Breath

N/A

Recruiting

Led By Mabi Singh, DMD,MS

Research Sponsored by Tufts University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

At least 18 years of age

Be older than 18 years old

Must not have

Subjects that have ever received therapeutic radiation in the head and neck area

Subject unable to provide consent (e.g. Cognitively impaired adults)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5, 30, 60 minute post application of product as well as degree of change after a 7 day period of use.

Awards & highlights

No Placebo-Only Group

Summary

This trial tests if Crest Daily Whitening Serum can help people with dry mouth and bad breath. The serum aims to make the mouth feel less dry, reduce bad breath, and whiten teeth.

Who is the study for?

This trial is for individuals experiencing dry mouth and bad breath. Specific eligibility criteria are not provided, so it's important to contact the study organizers for detailed information on who can participate.

What is being tested?

The trial is testing Crest Whitening Emulsions to see if they help with dry mouth and bad breath over a week of use. It aims to evaluate the effectiveness of this whitening agent in improving these conditions.

What are the potential side effects?

Potential side effects are not listed, but as with any dental product, there could be risks such as gum irritation or increased tooth sensitivity. Consultation with the study team is advised for more details.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 18 years old or older.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

Select...

I have received radiation therapy in my head or neck area.

Select...

I am unable to give consent due to cognitive impairment.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5, 30, 60 minute post application of product as well as degree of change after a 7 day period of use.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5, 30, 60 minute post application of product as well as degree of change after a 7 day period of use.

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5, 30, 60 minute post application of product as well as degree of change after a 7 day period of use. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Objective 1- Visual Analogue Scale for Perceived Dry Mouth

Secondary study objectives

Objective 2- Visual Analogue Scale for Perceived Bad Breath and Saliva Production Increase

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: ExperimentalExperimental Treatment1 Intervention

All subjects will be instructed to use the Crest Daily Whitening Serum for 1 week as described on the label. This product is available for purchase at any pharmacy.

0 / 3Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for dry mouth, such as moisturizing agents and saliva substitutes, work by hydrating the oral cavity and providing a protective coating to reduce dryness. These treatments often contain ingredients like glycerin or hyaluronic acid, which attract and retain moisture. Additionally, some products include antimicrobial agents or flavoring to neutralize and mask bad breath. This is crucial for dry mouth patients as it not only alleviates discomfort and difficulty in speaking or swallowing but also helps maintain oral hygiene and reduces the risk of dental issues and infections.

Effect of different mouthrinses on morning breath.