McMaster University

Summary

McMaster University is a medical facility located in HAMILTON, Ontario. This center is recognized for care of Asthma, Stroke, Crohn's Disease, Ulcerative Colitis, Hemophilia and other specialties. McMaster University is involved with conducting 258 clinical trials across 701 conditions. There are 41 research doctors associated with this hospital, such as Jeff S Healey, MD, Moin Khan, MD, Ryan Van Lieshout, MD, PhD, and Shamir Mehta, MD.

Top PIs

Clinical Trials running at McMaster University

Inflammatory Bowel Disease

Hemophilia B

Traumatic Brain Injury

Cancer

Ulcerative Colitis

Crohn's Disease

Stroke

Depression

Atrial Fibrillation

Atrial Flutter

Serotonin Signalling

for Inflammatory Bowel Disease

Alterations in normal serotonin (5-hydroxytryptamine;5-HT) signaling have been reported in ulcerative colitis (UC) and Crohn's disease (CD). Studies report an increase in enterochromaffin (EC) cell, main source of 5-HT in the gut, numbers in CD and UC patients. Up-regulated expression of mucosal Tryptophan hydroxylase (TPH)-1, catalytic enzyme in 5-HT production, messenger RNA (mRNA) have been found in CD patients in remission who are suffering the irritable bowel syndrome (IBS)-like symptoms. Alterations in normal 5-HT signaling has also been reported in animal models of inflammatory bowel disease (IBD). Thus, the aim of the proposed research project will be to study the alterations in 5-HT signalling accompanying GI inflammatory conditions, such as IBD.

Recruiting

1 award

N/A

2 criteria

Colonoscopy Screening

for Colorectal Cancer Risk in IBD

We will conduct a multicenter, parallel-group, non-inferiority RCT in persons with IBD undergoing colorectal neoplasia screening with high-definition white light colonoscopy, comparing a strategy of sampling visible lesions alone to a conventional strategy of sampling both visible lesions as well as normal-appearing mucosa using non-targeted biopsies. The primary outcome is the neoplasia detection rate. The required sample size to demonstrate non-inferiority is 1952 persons.

Recruiting

1 award

N/A

1 criteria

Inflammatory Bowel Disease

for Children

The CIDsCaNN Network is being established with the major goals of identifying why IBD develops so commonly in children and adolescents living in Canada, and of determining the best treatment strategies for different types of IBD. Focusing on a prospective, inception cohort of Canadian children of widely varied racial origins provides a unique opportunity to explore environmental risk factors early in life and close in time to disease onset, their influence on the host microbiome, and in the context of genetic susceptibility. In keeping with current treatment targets, assessed outcomes will include not only symptom resolution and growth, but also intestinal healing. We aim to identify best practice and to institute processes for continual improvement in care nationally.

Recruiting

1 award

N/A

1 criteria