Popular Trials
Antibody-drug conjugate
Intravesical Enfortumab Vedotin for Bladder Cancer
This trial tests a new treatment for bladder cancer by delivering the drug directly into the bladder through a thin tube. The study will determine the best dose and evaluate its effectiveness and side effects.
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Trials for Adenocarcinoma Patients
Monoclonal Antibodies
SGN-B6A for Cancer
This trial is testing a new drug called sigvotatug vedotin alone and with other treatments to see if it is safe and effective for people with solid tumors. It will also check for any side effects. The study includes different parts to determine the best dose and to see how well the drug works alone and in combination with other treatments.
Kinase Inhibitor
LOXO-435 for Bladder Cancer
This trial is testing LOXO-435, a new drug, to see if it can help treat advanced cancers with a specific genetic change. It aims to block a gene that helps cancer cells grow. The study will check the drug's safety and effectiveness in these patients. LOX may be a potential effective therapeutic target to treat colorectal cancer.
Monoclonal Antibodies
MK-7684A for Advanced Cancers
This trial is testing a new treatment that combines two medications to see if it works better than the current treatment for serious cancers, particularly cervical cancer. One of the medications has shown promising results in treating various cancers, including cervical cancer. The goal is to find out if this combination can improve patient outcomes by helping the immune system fight cancer more effectively.
Trials for Breast Cancer Patients
Monoclonal Antibodies
SGN-B6A for Cancer
This trial is testing a new drug called sigvotatug vedotin alone and with other treatments to see if it is safe and effective for people with solid tumors. It will also check for any side effects. The study includes different parts to determine the best dose and to see how well the drug works alone and in combination with other treatments.
Monoclonal Antibodies
MK-7684A for Advanced Cancers
This trial is testing a new treatment that combines two medications to see if it works better than the current treatment for serious cancers, particularly cervical cancer. One of the medications has shown promising results in treating various cancers, including cervical cancer. The goal is to find out if this combination can improve patient outcomes by helping the immune system fight cancer more effectively.
Trials for Metastatic Patients
Monoclonal Antibodies
SGN-B6A for Cancer
This trial is testing a new drug called sigvotatug vedotin alone and with other treatments to see if it is safe and effective for people with solid tumors. It will also check for any side effects. The study includes different parts to determine the best dose and to see how well the drug works alone and in combination with other treatments.
PARP Inhibitor
Durvalumab + Olaparib for Bladder Cancer
This trial tests a combination of two drugs, durvalumab and olaparib, for patients with advanced bladder cancer who can't receive standard chemotherapy. Durvalumab helps the immune system attack cancer, while olaparib makes it harder for cancer cells to repair themselves. The goal is to see if this combination is more effective than using durvalumab alone.
Antibody-Drug Conjugate
Enfortumab Vedotin for Bladder Cancer
This trial is testing a new drug called enfortumab vedotin alone and with other treatments in patients with advanced or muscle-invasive bladder cancer. The goal is to see how well these treatments work and what side effects they might have. Enfortumab vedotin targets and kills cancer cells, while pembrolizumab helps the immune system fight the cancer.
Kinase Inhibitor
LOXO-435 for Bladder Cancer
This trial is testing LOXO-435, a new drug, to see if it can help treat advanced cancers with a specific genetic change. It aims to block a gene that helps cancer cells grow. The study will check the drug's safety and effectiveness in these patients. LOX may be a potential effective therapeutic target to treat colorectal cancer.
Phase 3 Trials
Monoclonal Antibodies
Pembrolizumab + Chemoradiotherapy for Bladder Cancer
This trial will compare the effectiveness of a new cancer treatment (pembrolizumab + chemoradiotherapy) to the current standard of care (chemoradiotherapy alone) for people with muscle-invasive bladder cancer.
Chemotherapy
Chemotherapy + Nivolumab for Bladder Cancer
This trial will compare the efficacy of nivolumab plus neoadjuvant gemcitabine/cisplatin chemotherapy followed by post-surgery continuation of immuno-oncology therapy versus neoadjuvant gemcitabine/cisplatin chemotherapy alone in adult participants with previously untreated muscle-invasive bladder cancer.
Monoclonal Antibodies
TAR-200 + Cetrelimab vs Chemoradiotherapy for Bladder Cancer
This trial is testing a new treatment for bladder cancer that combines a device delivering medication directly to the bladder with a drug that helps the immune system fight cancer. The goal is to see if this combination works better than the usual treatment in keeping the bladder free from cancer events.
Monoclonal Antibodies
Immunotherapy + Chemotherapy for Bladder Cancer
This trial is studying if adding the drugs durvalumab and tremelimumab to standard chemotherapy can help to control transitional cell carcinoma of the urothelium that has spread to other parts of the body and cannot be removed by surgery.
Immunotherapy
N-803 + BCG for Bladder Cancer
This trial is testing a new drug, N-803, for people with bladder cancer that has not responded to BCG treatment. Patients will receive the new drug through a urinary catheter weekly for 6 weeks, followed by maintenance treatment every 3 or 6 weeks for up to 3 years.
PD-L1 Inhibitor
Durvalumab + BCG for Bladder Cancer
This trial is testing a new treatment that combines two therapies to help the immune system fight bladder cancer. It targets patients whose cancer has not spread into the muscle layer of the bladder. The treatment works by helping the body's defense system recognize and destroy cancer cells more effectively.
Trials With No Placebo
Monoclonal Antibodies
TAR-200 + Cetrelimab for Bladder Cancer
This trial is testing a drug-delivery device (TAR-200) and an immune-boosting drug (cetrelimab) in bladder cancer patients who have not responded well to other treatments. TAR-200 releases medicine directly into the bladder, while cetrelimab helps the immune system fight cancer. Cetrelimab is being studied in patients with different types of bladder cancer.
Monoclonal Antibodies
SGN-B6A for Cancer
This trial is testing a new drug called sigvotatug vedotin alone and with other treatments to see if it is safe and effective for people with solid tumors. It will also check for any side effects. The study includes different parts to determine the best dose and to see how well the drug works alone and in combination with other treatments.
Enhanced MRI for Bladder Cancer Staging
This trial is testing a new way to use MRI to look for bladder cancer. A contrast agent is used to help better visualize the tumor. The MRI images are then reviewed by two radiologists to determine the stage of the cancer.
Tyrosine Kinase Inhibitor
Erdafitinib vs Chemotherapy for Bladder Cancer
This trial tests erdafitinib, a pill that targets proteins to stop cancer growth, in patients with a type of bladder cancer that has returned after standard treatment. The drug blocks signals that help cancer cells grow. Erdafitinib is approved for treating a specific type of advanced bladder cancer.
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Frequently Asked Questions
Introduction to bladder cancer
What are the top hospitals conducting bladder cancer research?
Bladder cancer, a condition that affects thousands of individuals across the country, has prompted top hospitals to spearhead clinical trials in search of innovative treatments and improved outcomes. In Myrtle Beach, the Carolina Urologic Research Center has taken charge with an impressive ten active bladder cancer trials and a total of 29 trials conducted to date. Since their first recorded bladder cancer trial in 2007, this dedicated center has been committed to advancing research and patient care. Not far away, Memorial Sloan Kettering Cancer Center in New york City stands as another prominent institution making strides in the field. With nine ongoing bladder cancer trials and a history of 33 completed studies since their inaugural trial in 2004, they are at the forefront of groundbreaking discoveries.
In Saint Louis at Washington University School of Medicine, researchers have undertaken six active clinical trials for bladder cancer, building on their expertise from conducting 20 previous studies since they began investigating this disease in 2005. Meanwhile, Northwestern University located in Chicago is also contributing significantly with its own set of six ongoing bladder cancer trials while having accomplished 14 prior investigations since starting their pioneering work relatively recently in2012.The Moffitt Cancer Center situated in Tampa may seem smaller-scale by comparison but plays an equally vital role within the medical community; it currently hosts six active clinical tests specifically focusing on bladder cancers following twenty-one earlier experiments which commenced only ten years agoin2010.
Through these select institutions' dedication and unwavering commitment to finding effective treatments for bladder cancer patients, hope is kindled for those affected by this challenging condition around the nation. As each new trial pushes boundaries and uncovers potential breakthroughs towards conquering this disease altogether,it marks a step closer toward offering brighter horizons for countless individuals grappling with such diagnosis globally
Which are the best cities for bladder cancer clinical trials?
When it comes to bladder cancer clinical trials, several cities have emerged as leading hubs for research and development. New york City tops the list with 50 active trials investigating treatments like Pembrolizumab, Enfortumab vedotin, and Nivolumab. Following closely behind is Los Angeles, California, with 36 ongoing studies focusing on pharmacological approaches such as TAR-200 + Cetrelimab and UGN-102. Nashville, Tennessee also stands out with 26 active trials exploring options like TAR-200 and Sapanisertib. Boston, Massachusetts follows suit with 25 trials examining Sapanisertib, Cobimetinib, and Nivolumab. Lastly, Atlanta, Georgia offers individuals access to 21 active trials studying treatments including enfortumab vedotin (EV) and Genistein. These cities serve as important centers for advancing bladder cancer care through cutting-edge clinical research efforts.
Which are the top treatments for bladder cancer being explored in clinical trials?
Bladder cancer research is advancing rapidly, with several promising treatments currently being explored in clinical trials. Leading the pack is pembrolizumab, a groundbreaking drug that has caught the attention of researchers through its involvement in seven active bladder cancer trials. Since its introduction in 2015, it has amassed an impressive 43 all-time clinical trials dedicated to fighting this disease. Close behind is nivolumab, another notable contender with five ongoing trials and 26 all-time bladder cancer studies since its debut in 2015. Atezolizumab also shows great promise, participating in four active and 19 all-time clinical trials for bladder cancer since it was first listed back in 2014. Additionally, enfortumab vedotin and erdafitinib are making strides with three active trials each and showing encouraging potential as effective treatments for this challenging condition. As these innovative therapies continue to undergo rigorous investigation, hope grows stronger for improved outcomes among patients battling bladder cancer worldwide
What are the most recent clinical trials for bladder cancer?
Exciting advancements in bladder cancer research have led to several recent clinical trials that hold promise for patients. Among these trials is TARA-002, which has progressed to Phase 1 and Phase 2 stages, displaying encouraging results. Another trial focuses on Transurethral Resection of Bladder Tumor as a potential treatment option for bladder cancer, with Phase 1 findings showing positive outcomes. Additionally, the use of sacituzumab govitecan in Phase 2 studies demonstrates its potential efficacy in combating bladder cancer. The TARA-002 trial also shows promise in early-stage development (Phase 1), while a separate study explores the benefits of IO102-IO103 and pembrolizumab combination therapy in treating this aggressive disease. These remarkable clinical trials offer hope and new possibilities for individuals battling bladder cancer.
What bladder cancer clinical trials were recently completed?
Recently concluded clinical trials have made significant strides in the field of bladder cancer, offering new hope for patients. Among them, Vaxiion Therapeutics' trial on VAX014 concluded in May 2019, while Nektar Therapeutics completed their study on Bempegaldesleukin in April 2019. Furthermore, PrECOG's investigation into the combination therapy Nivolumab/Lirilumab reached completion in March 2019. These advancements showcase the tireless efforts of researchers and encourage optimism for improved treatments against bladder cancer.