Popular Trials
Vitamin
Vitamin D + Fish Oil for Health Improvement
This trial is studying whether taking daily dietary supplements of vitamin D3 or omega-3 fatty acids reduces the risk of developing cancer, heart disease, and stroke in people who do not have a prior history of these illnesses.
Orthopedic Implant
Titanium Knee Implant for Knee Arthritis
This trial evaluates the safety and effectiveness of the Persona Ti-Nidium implant in patients needing knee replacement surgery. The implant aims to improve movement and reduce pain by replacing damaged knee parts with an artificial joint. The study will follow patients for several years to assess long-term outcomes. The Persona® system is a newly launched implant designed for total knee replacement with innovations intended for better function and higher flexibility.
Senolytic + Anti-Fibrotic Agents for Osteoarthritis
This trial is testing whether a senolytic agent (Fisetin) and an anti-fibrotic agent (Losartan), used independently or in combination, can improve the beneficial effect of an active control (injection of autologous bone marrow aspirate concentrate (BMAC) into an osteoarthritic knee).
Procedure
PPS Injections for Knee Osteoarthritis
This trial is testing the effectiveness of a drug called pentosan polysulfate sodium (PPS) for treating knee pain caused by osteoarthritis. The study will last up to 80 weeks, and participants will receive either PPS injections or placebo injections.
Popular Filters
Trials for Hip Osteoarthritis Patients
Non-Surgical Interventions for Knee Osteoarthritis
This trial will compare commonly recommended treatments to reduce pain and functional limitations in KOA. The results will lead to improved patient selection for treatment and inform evidence based guidelines by offering well-tested, effective, non-surgical alternatives.
Corticosteroid
Corticosteroid Injection for Thumb Arthritis
This trial tests two types of injections for adults with thumb arthritis. One injection contains a steroid to reduce inflammation and a numbing medicine for quick pain relief. The other injection contains a saltwater solution and a numbing medicine. The goal is to see which injection is more effective in reducing pain and improving hand function over several months. Steroid injections have been shown to be effective in reducing pain and improving function in various joint conditions.
Serotonin-Norepinephrine Reuptake Inhibitor
Exercise + Duloxetine for Knee Osteoarthritis
This trial tests a treatment combining duloxetine and aerobic exercise for adults with knee osteoarthritis and depression. Duloxetine helps manage pain and mood, making it easier for patients to stick to their exercise routine. Duloxetine, an anti-depressant medication, has been recently approved for managing knee osteoarthritis and has shown effectiveness in reducing pain and improving function in patients with osteoarthritis.
Trials for OA Patients
Non-Surgical Interventions for Knee Osteoarthritis
This trial will compare commonly recommended treatments to reduce pain and functional limitations in KOA. The results will lead to improved patient selection for treatment and inform evidence based guidelines by offering well-tested, effective, non-surgical alternatives.
Corticosteroid
Corticosteroid Injection for Thumb Arthritis
This trial tests two types of injections for adults with thumb arthritis. One injection contains a steroid to reduce inflammation and a numbing medicine for quick pain relief. The other injection contains a saltwater solution and a numbing medicine. The goal is to see which injection is more effective in reducing pain and improving hand function over several months. Steroid injections have been shown to be effective in reducing pain and improving function in various joint conditions.
Serotonin-Norepinephrine Reuptake Inhibitor
Exercise + Duloxetine for Knee Osteoarthritis
This trial tests a treatment combining duloxetine and aerobic exercise for adults with knee osteoarthritis and depression. Duloxetine helps manage pain and mood, making it easier for patients to stick to their exercise routine. Duloxetine, an anti-depressant medication, has been recently approved for managing knee osteoarthritis and has shown effectiveness in reducing pain and improving function in patients with osteoarthritis.
Phase 3 Trials
Non-Surgical Interventions for Knee Osteoarthritis
This trial will compare commonly recommended treatments to reduce pain and functional limitations in KOA. The results will lead to improved patient selection for treatment and inform evidence based guidelines by offering well-tested, effective, non-surgical alternatives.
Procedure
TG-C for Knee Osteoarthritis
This trial tests TG-C, an injection into the knee, for people with moderate to severe knee osteoarthritis. It aims to see if TG-C can reduce pain and improve knee function by potentially altering the disease. The study will monitor patients for safety and effectiveness over time. TG-C has been previously studied for its potential to improve knee joint function and reduce pain in osteoarthritis patients.
Procedure
TG-C for Osteoarthritis of the Knee
This trial tests TG-C, an injection into the knee, for patients with moderate to severe osteoarthritis. It aims to reduce pain and improve knee function by potentially modifying the disease. TG-C has shown promise in previous studies for managing knee osteoarthritis.
Cannabinoid
CBD for Knee Osteoarthritis
This trial is testing if CBD tablets that dissolve in the mouth can reduce pain and improve function in people with knee osteoarthritis. The study targets patients who are already doing physiotherapy and home exercises. CBD is thought to work by interacting with the body's system that controls pain and inflammation. CBD is a non-euphoric component of cannabis that has shown potential in relieving pain and reducing inflammation in osteoarthritis.
Stem Cell Therapy
BMAC vs Triamcinolone for Hip Osteoarthritis
This trial compares two treatments for hip osteoarthritis: one that uses the patient's own bone marrow cells to promote healing, and another that uses a steroid to quickly reduce inflammation. The study aims to determine which treatment offers better long-term pain relief and improved mobility.
Trials With No Placebo
Non-Surgical Interventions for Knee Osteoarthritis
This trial will compare commonly recommended treatments to reduce pain and functional limitations in KOA. The results will lead to improved patient selection for treatment and inform evidence based guidelines by offering well-tested, effective, non-surgical alternatives.
Serotonin-Norepinephrine Reuptake Inhibitor
Exercise + Duloxetine for Knee Osteoarthritis
This trial tests a treatment combining duloxetine and aerobic exercise for adults with knee osteoarthritis and depression. Duloxetine helps manage pain and mood, making it easier for patients to stick to their exercise routine. Duloxetine, an anti-depressant medication, has been recently approved for managing knee osteoarthritis and has shown effectiveness in reducing pain and improving function in patients with osteoarthritis.
Platelet-Rich Plasma
Platelet-Rich Plasma vs Hyaluronic Acid for Osteoarthritis
This trial is testing whether platelet-rich plasma (PRP) is more effective than hyaluronic acid (HA) in treating knee osteoarthritis, as measured by changes in cartilage thickness and pain/function scores. Approximately 100 subjects will be treated at NorthShore University HealthSystem.
Stem Cell Therapy
BMAC vs Triamcinolone for Hip Osteoarthritis
This trial compares two treatments for hip osteoarthritis: one that uses the patient's own bone marrow cells to promote healing, and another that uses a steroid to quickly reduce inflammation. The study aims to determine which treatment offers better long-term pain relief and improved mobility.
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Frequently Asked Questions
Introduction to oa
What are the top hospitals conducting oa research?
When it comes to clinical trials focused on osteoarthritis (OA), several leading hospitals across the United States are spearheading innovative research efforts. In Boston, Brigham and Women's Hospital is at the forefront with four ongoing OA trials. This renowned institution is dedicated to finding solutions for this degenerative joint disease that affects millions of people worldwide. Similarly, in Seattle, the University of Washington is actively conducting four clinical trials centered around OA, focusing on understanding the causes and developing effective treatments. In Chicago, Rush University Medical Center is making strides with three active OA trials aimed at improving quality of life for individuals living with this condition.
Heading east towards New york City, we find NYU Langone Health contributing its expertise through three ongoing OA trials. With a strong focus on patient-centered care and cutting-edge research, they aim to alleviate pain and enhance mobility for individuals impacted by OA.
Lastly, in Gainesville, Florida, researchers at the University of Florida are also dedicating themselves to combatting OA through their involvement in three active clinical trials. These studies strive to unravel the underlying mechanisms behind this debilitating condition while exploring novel treatment approaches.
While these hospitals have not conducted any all-time OA trials as of yet—suggesting an area where further exploration may be needed—their commitment combined with advancements made elsewhere bring hope to those suffering from osteoarthritis. Through collaboration and continued research efforts among these esteemed institutions nationwide, breakthroughs could soon be within reach for millions affected by this prevalent joint disease
Which are the best cities for oa clinical trials?
When it comes to osteoarthritis clinical trials, several cities are leading the way in research and development. New york, with 23 active trials, focuses on interventions like Active Treatment (TG-C), Vancomycin powder, and Phase 1: Best Practices + Duloxetine + Pain coping skills. Chicago follows closely behind with 17 ongoing studies exploring treatments such as Lorecivivint and Vancomycin powder. Miami and San Antonio both have 12 active trials each, investigating options like Pentosan Polysulfate Sodium twice weekly and Lorecivivint. Lastly, Birmingham offers 11 active trials examining interventions including Reparel Knee Sleeve alongside other potential breakthroughs in osteoarthritis management. These cities provide individuals with access to cutting-edge clinical trials that aim to improve the quality of life for those living with osteoarthritis.
Which are the top treatments for oa being explored in clinical trials?
Clinical trials are actively investigating several cutting-edge treatments for osteoarthritis (OA). At the forefront of research is JAK inhibitors, which have shown promising results in reducing inflammation and slowing down disease progression. Another exciting area of exploration is stem cell therapy, with researchers exploring the potential of using mesenchymal stem cells to regenerate damaged cartilage. Additionally, growth factors like platelet-rich plasma (PRP) are being studied for their ability to promote tissue repair and alleviate OA symptoms. These innovative therapies offer hope for improved management and relief from the debilitating effects of OA.
What are the most recent clinical trials for oa?
Recent clinical trials have brought promising developments in the treatment of osteoarthritis (OA). One notable trial explores the potential benefits of Celltex-AdMSCs, a Phase 2 study that investigates the use of adult mesenchymal stem cells derived from adipose tissue for OA. Additionally, ASA is being evaluated in a Phase 3 trial as a potential therapy for OA. Another trial focuses on Group A TA 40 mg and its effects on OA patients during its Phase 4 stage. Furthermore, an intervention study encompassing both Phase 1 and Phase 2 aims to assess novel approaches for managing OA symptoms. Lastly, GNSC-001 at low doses is being investigated through a Phase 1 trial to determine its efficacy in treating OA. These comprehensive investigations offer hope for improved therapeutic options in tackling this widespread condition
What oa clinical trials were recently completed?
Recently, several clinical trials have been completed, bringing us closer to advancing our understanding and treatment of osteoarthritis (OA). These trials include investigations into new therapies and interventions aimed at mitigating the impact of OA on patients' lives. While specific details may vary, these studies collectively contribute valuable insights that can potentially lead to better options for managing this degenerative joint disease.