Popular Trials
CAR T-cell Therapy
Genetically Modified T-Cells + Aldesleukin for Melanoma
This trial is testing genetically modified T-cells followed by aldesleukin to treat melanoma. T-cells are a type of white blood cell that help the body fight infections. Genes that may help the T-cells recognize melanoma cells are placed into the T-cells in the laboratory. Adding these genes to the T cells may help them kill more tumor cells when they are put back in the body. Aldesleukin may enhance this effect by stimulating white blood cells to kill more melanoma cells.
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Trials for Squamous Cell Carcinoma Patients
Immunotherapy
OBX-115 for Skin Cancer
This trial tests a new treatment called OBX-115 for adults with advanced solid tumors. It aims to see if the treatment is safe and effective by measuring its ability to shrink tumors, control disease progression, and improve survival.
Cell Transfer Therapy
Cell Therapy + Chemo + TBI for Skin Cancer
This trial is testing whether an experimental treatment for metastatic melanoma, which involves cell therapy, is more effective when given with chemotherapy and total body irradiation, or just with chemotherapy.
Chemotherapy
Riluzole + Sorafenib for Melanoma
This trial tests the safety and best dose of combining riluzole and sorafenib tosylate for patients with advanced solid tumors or melanoma that don't respond to standard treatments. Riluzole may slow tumor growth, and sorafenib tosylate blocks processes needed for tumor growth. The combination aims to kill more tumor cells.
Trials for Basal Cell Carcinoma Patients
Immunotherapy
OBX-115 for Skin Cancer
This trial tests a new treatment called OBX-115 for adults with advanced solid tumors. It aims to see if the treatment is safe and effective by measuring its ability to shrink tumors, control disease progression, and improve survival.
Cell Transfer Therapy
Cell Therapy + Chemo + TBI for Skin Cancer
This trial is testing whether an experimental treatment for metastatic melanoma, which involves cell therapy, is more effective when given with chemotherapy and total body irradiation, or just with chemotherapy.
Chemotherapy
Riluzole + Sorafenib for Melanoma
This trial tests the safety and best dose of combining riluzole and sorafenib tosylate for patients with advanced solid tumors or melanoma that don't respond to standard treatments. Riluzole may slow tumor growth, and sorafenib tosylate blocks processes needed for tumor growth. The combination aims to kill more tumor cells.
Trials for Metastatic Patients
Immunotherapy
OBX-115 for Skin Cancer
This trial tests a new treatment called OBX-115 for adults with advanced solid tumors. It aims to see if the treatment is safe and effective by measuring its ability to shrink tumors, control disease progression, and improve survival.
Protein Kinase Inhibitor
MK2206 + Hydroxychloroquine for Advanced Cancers
This trial is testing the side effects and best dose of Akt inhibitor MK2206 with hydroxychloroquine in treating patients with advanced solid tumors, melanoma, prostate or kidney cancer.
Cell Transfer Therapy
Cell Therapy + Chemo + TBI for Skin Cancer
This trial is testing whether an experimental treatment for metastatic melanoma, which involves cell therapy, is more effective when given with chemotherapy and total body irradiation, or just with chemotherapy.
Trials for BRAF Positive Patients
Immunotherapy
OBX-115 for Skin Cancer
This trial tests a new treatment called OBX-115 for adults with advanced solid tumors. It aims to see if the treatment is safe and effective by measuring its ability to shrink tumors, control disease progression, and improve survival.
Checkpoint Inhibitor
Nivolumab + Ipilimumab + Sargramostim for Advanced Melanoma
This trial is studying nivolumab and ipilimumab to see how well they work with or without sargramostim in treating patients with stage III-IV melanoma that cannot be removed by surgery.
BRAF Inhibitor
Immunotherapy + Targeted Therapy for Melanoma
This trial is testing two different treatments for melanoma that cannot be removed by surgery. The first treatment is immunotherapy with monoclonal antibodies, followed by targeted therapy with dabrafenib and trametinib. The second treatment is targeted therapy with dabrafenib and trametinib, followed by immunotherapy with monoclonal antibodies. It is not yet known which treatment is more effective.
B-cell lymphoma-2 (BCL-2) inhibitor
Navitoclax + Dabrafenib + Trametinib for Melanoma
This trial is studying the side effects and best dose of a combination of dabrafenib, trametinib, and navitoclax to treat patients with BRAF mutant melanoma or solid tumors.
Phase 3 Trials
Checkpoint Inhibitor
Nivolumab + Ipilimumab + Sargramostim for Advanced Melanoma
This trial is studying nivolumab and ipilimumab to see how well they work with or without sargramostim in treating patients with stage III-IV melanoma that cannot be removed by surgery.
BRAF Inhibitor
Immunotherapy + Targeted Therapy for Melanoma
This trial is testing two different treatments for melanoma that cannot be removed by surgery. The first treatment is immunotherapy with monoclonal antibodies, followed by targeted therapy with dabrafenib and trametinib. The second treatment is targeted therapy with dabrafenib and trametinib, followed by immunotherapy with monoclonal antibodies. It is not yet known which treatment is more effective.
Behavioural Intervention
Skin Cancer Prevention Strategies for Skin Cancer
This trial aims to identify intervention approaches that help people avoid sunburn and motivate sun protection, by testing 3 personalized risk components over 1 year with 528 people.
Trials With No Placebo
Immunotherapy
OBX-115 for Skin Cancer
This trial tests a new treatment called OBX-115 for adults with advanced solid tumors. It aims to see if the treatment is safe and effective by measuring its ability to shrink tumors, control disease progression, and improve survival.
Protein Kinase Inhibitor
MK2206 + Hydroxychloroquine for Advanced Cancers
This trial is testing the side effects and best dose of Akt inhibitor MK2206 with hydroxychloroquine in treating patients with advanced solid tumors, melanoma, prostate or kidney cancer.
Cell Transfer Therapy
Cell Therapy + Chemo + TBI for Skin Cancer
This trial is testing whether an experimental treatment for metastatic melanoma, which involves cell therapy, is more effective when given with chemotherapy and total body irradiation, or just with chemotherapy.
View More Related Trials
Frequently Asked Questions
Introduction to skin cancer
What are the top hospitals conducting skin cancer research?
In the battle against skin cancer, several hospitals across the United States are leading the way in groundbreaking clinical trials. Among them is Houston's M D Anderson Cancer Center, where a remarkable 16 ongoing trials for skin cancer are currently underway. With an impressive history of 31 completed trials since their first recorded investigation in 1999, this institution has remained at the forefront of cutting-edge research and treatment development. Not far behind is the University of Alabama at Birmingham Cancer Center in Birmingham, which boasts 11 active skin cancer trials and a total of 14 conducted studies since initiating their pioneering trial in 2000.
Meanwhile, Penrose-Saint Francis Healthcare in Colorado Springs and Porter Adventist Hospital in Denver have both demonstrated their commitment to advancing our understanding and treatment options for skin cancer with ten ongoing clinical trials each. These institutions have already contributed significantly to previous investigations with thirteen all-time conducted studies starting from their inaugural trial year of 2005.
Notably, Emory University Hospital/Winship Cancer Institute makes its mark on this list as well with nine current skin cancer clinical trials and an admirable tally of sixteen previously accomplished studies dating back to their earliest recorded trial in 2000. Together, these hospitals represent vital centers for hope and progress when it comes to combating this prevalent form of cancer.
As we continue to strive towards better outcomes for those affected by skin cancer nationwide, these renowned institutions serve as beacons for innovation within medical research. Each new discovery brings us one step closer to effective treatments that can save lives while raising awareness about prevention methods like sun protection practices - such as using sunscreen regularly or seeking shade during peak hours - remains crucial.
Which are the best cities for skin cancer clinical trials?
When it comes to skin cancer clinical trials, several cities emerge as leaders in research and development. Denver, Colorado, takes the top spot with 59 active trials investigating treatments like Ipilimumab, Pembrolizumab, and Dabrafenib Mesylate. Anchorage, Alaska closely follows with 51 ongoing studies focusing on innovative approaches such as Dabrafenib Mesylate and Subprotocol C2 (MET exon 14 deletion/mutation). Los Angeles, California also proves to be a hub for skin cancer research with 44 active trials exploring Pembrolizumab, Ipilimumab, and Dabrafenib Mesylate. These cities provide individuals battling skin cancer access to cutting-edge clinical trials that pave the way for advancements in care and offer hope for improved outcomes.
Which are the top treatments for skin cancer being explored in clinical trials?
Skin cancer research is advancing rapidly, with several promising treatments currently being explored in clinical trials. Leading the way is pembrolizumab, a powerful drug that is the focus of nine active trials for skin cancer. Since its introduction in 2015, it has been involved in a total of 33 skin cancer trials. Close behind is ipilimumab, which is being investigated in eight active and 31 all-time skin cancer trials since its debut in 2010. Another noteworthy contender on the list is nivolumab, currently participating in three ongoing skin cancer studies and having accumulated an impressive record of 33 all-time trials since its first listing back in 2013. Additionally, there are three active pharmacological studies examining new approaches to treating this condition. As researchers continue their relentless pursuit for effective therapies against skin cancer, these treatments offer hope for patients worldwide
What are the most recent clinical trials for skin cancer?
Recent clinical trials for skin cancer have provided promising insights into potential treatment options. A Phase 4 trial investigated the efficacy of aminolevulinic acid hydrochloride gel, 10%, in addressing skin cancer. Another trial focused on Encorafenib, evaluating its effectiveness as a therapeutic approach in Phase 2 studies. Additionally, Cabozantinib S-malate underwent Phase 1 testing to assess its potential benefits for patients with skin cancer. Finally, Tocilizumab was examined in a Phase 2 trial to determine its impact on managing this challenging condition. These recent clinical trials offer hope and may contribute to improved treatment strategies for individuals affected by skin cancer.
What skin cancer clinical trials were recently completed?
In recent years, several clinical trials addressing various aspects of skin cancer have reached completion. Morphogenesis, Inc.'s trial investigating IFx-Hu2.0 concluded in June 2021, while Rockefeller University's study on 2141 V-11 wrapped up in January 2020. Additionally, the University of Arizona completed a trial involving the injection of TVEC into target lesions in August 2018. Other notable completed trials include studies conducted by the University of California, San Francisco (April 2018) testing Aspirin as a potential treatment and M.D. Anderson Cancer Center's investigations on Relatlimab (February 2016), Pembrolizumab (August 2015), and CXCR2-transduced Autologous Tumor Infiltrating Lymphocytes (January 2015). These trials shed light on ongoing efforts to advance our understanding and management of skin cancer for the benefit of patients worldwide.