Dr. Benjamin Van Tassell, PharmD

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Virginia Commonwealth University

Studies Heart Failure
Studies Hepatitis C
3 reported clinical trials
2 drugs studied

Affiliated Hospitals

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Virginia Commonwealth University

Clinical Trials Benjamin Van Tassell, PharmD is currently running

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Anakinra

for Heart Attack Prevention of Heart Failure

Patients who have a heart attack are at high risk for future development of heart failure ('weakening of the heart'). The researchers believe that the reaction of the heart muscle to injury (inflammation) during a heart attack may be contributing to the risk of heart failure. The current study will test the ability of an anti-inflammatory medicine (anakinra) to block the inflammation in the body during and after a heart attack.

Recruiting

0 awards

Phase 2

4 criteria

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Anakinra

for Heart Failure

End-stage heart failure (HF) is a progressive illness with a mortality rate similar to most advanced cancers.Roughly 5% of patients with HF have end-stage disease that is refractory to medical therapy (stage D heart failure). When patients reach this point in their disease, the only treatments known to prolong life are cardiac transplantation or left ventricular assist devices. In patients who do not qualify for these options, or elect a palliative approach, inotropes are frequently used to improve hemodynamics through an increase in cardiac output and reduction in filling pressures. While inotropes provide profound symptomatic relief, these benefits are accompanied by significant risks of progressive adverse cardiac remodeling, arrhythmias, and sudden death. There is, therefore, an urgent need to develop strategies to reduce the dose or duration of inotrope use in the management of patients with stage D of HF.

Recruiting

1 award

Phase 1

6 criteria

More about Benjamin Van Tassell, PharmD

Clinical Trial Related

3 years of experience running clinical trials · Led 3 trials as a Principal Investigator · 2 Active Clinical Trials

Treatments Benjamin Van Tassell, PharmD has experience with

  • Anakinra
  • Placebo

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