Dr. Bradley Lega, MD
Claim this profileUT Southwestern Medical Center
Studies Epilepsy
Studies Memory Loss
5 reported clinical trials
6 drugs studied
Affiliated Hospitals
Clinical Trials Bradley Lega, MD is currently running
Deep Brain Stimulation
for Schizophrenia
There are three hypotheses proposed for this study: 1) Participants will report no unanticipated serious adverse events during the eight months of treatment. 2) Investigators will successfully model psychotic versus non-psychotic brain states using support vector machine (SVM) classifiers. 3) Participants specific brain stimulation parameters can induce a change in the brain state consistent with non-psychotic states as measured by classifier output. Hypotheses 1, 2, and 3 address safety and tolerability, efficacy, and the putative mechanism of successful treatment. The overall objective is to use next generation Deep Brain Stimulation (DBS) combined with antecedent stereo electroencephalogram (SEEG) mapping to establish a new therapy for treatment-refractory schizophrenia given the limitations of current treatment modalities. The primary objective is to demonstrate safety of acute and chronic network guided stimulation for treatment-refractory schizophrenia. Exploratory Objectives: 1. Use intracranial mapping (SEEG) combined with pharmacological manipulation of psychotic states to create a protocol for participant specific deep brain stimulation to treat treatment-refractory schizophrenia. 2. Develop closed loop stimulation protocols to modify brain states during psychotic brain activity induced by low-dose ketamine administration. 3. Investigate the use of mnemonic similarity to characterize brain networks related to symptoms of treatment-refractory schizophrenia. 4. Treatment-related objectives: Record a reduction in psychotic symptoms, as well as an improvement in psychosocial function and cognition.
Recruiting1 award N/A
Scopolamine
for Memory Loss
The goal of this study is to learn about the effects of scopolamine (an anticholinergic drug) on areas of the brain involved in memory, and changes it may have on brain activity. The investigators will do this by testing epileptic patients who are already undergoing intracranial surgery for seizure monitoring, and measuring the activity from the brain areas being assessed. The main questions it aims to answer are 1) whether scopolamine changes memory activity solely at encoding (the time when the person perceives and determines to remember an item or event) as has previously been found, or if it also can selectively impact retrieval (when the item or event which has been processed is recalled or remembered), and 2) what the nature of the brain activity changes is. Participants will complete two treatment arms. One of these will be with the drug, and the other will be with a saline solution, so that the participants are unaware which session the actual drug has been received. Patients will complete a verbal and/or spatial task each of the two days. An anesthesiologist will administer either the drug or the saline at a critical point which addresses both of the research questions. Researchers will compare the brain activity between the two treatment arms to determine what brain activity changes, and at what time point during memory formation.
Recruiting0 awards Phase < 15 criteria
More about Bradley Lega, MD
Clinical Trial Related10 years of experience running clinical trials · Led 5 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Bradley Lega, MD has experience with
- Placebo
- Scopolamine
- Deep Brain Stimulation
- Direct Electrical Stimulation
- SetPoint System
- Robotic NeuroBlate System
Breakdown of trials Bradley Lega, MD has run
Epilepsy
Memory Loss
Mild Cognitive Impairment
Seizures
Schizophrenia
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Bradley Lega, MD specialize in?
Bradley Lega, MD focuses on Epilepsy and Memory Loss. In particular, much of their work with Epilepsy has involved treating patients, or patients who are undergoing treatment.
Is Bradley Lega, MD currently recruiting for clinical trials?
Yes, Bradley Lega, MD is currently recruiting for 2 clinical trials in Dallas Texas. If you're interested in participating, you should apply.
Are there any treatments that Bradley Lega, MD has studied deeply?
Yes, Bradley Lega, MD has studied treatments such as Placebo, Scopolamine, Deep Brain Stimulation.
What is the best way to schedule an appointment with Bradley Lega, MD?
Apply for one of the trials that Bradley Lega, MD is conducting.
What is the office address of Bradley Lega, MD?
The office of Bradley Lega, MD is located at: UT Southwestern Medical Center, Dallas, Texas 75390 United States. This is the address for their practice at the UT Southwestern Medical Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.