Dr. Michael Khoury, MD
Claim this profileUniversity of Alberta
Studies Acute Lymphoblastic Leukemia
Studies Heart Transplant
3 reported clinical trials
1 drug studied
Affiliated Hospitals
Clinical Trials Michael Khoury, MD is currently running
High-Intensity Interval Training
for Pediatric Heart Transplant Recipients
Heart transplantation is the long-term treatment for children and adults with advanced heart failure. Post-transplant outcomes have improved over time, such that 50% of pediatric heart transplant recipients (HTR) remain alive with a need for re-transplantation 17-years following the initial transplant. With improved short- and medium-term outcomes, focus has shifted towards optimizing long-term survival and reducing transplant-associated morbidities. This includes strategies aimed at optimizing cardiorespiratory fitness and physical activity levels. Pediatric and adult HTRs have reduced exercise capacity compared with the general population. Previous groups have shown gradual improvements in heart rate response to exercise and exercise capacity in pediatric HTRs. However, after an initial improvement, exercise capacity appears to plateau, or even decline in pediatric HTRs, and remains sub-optimal compared with the general population. Most exercise interventions in HTRs to date have focused on moderate-intensity continuous exercise (MICE), with some resistance components incorporated. More recently, high-intensity interval training (HIIT), consisting of short, intense bursts of exercise with rest periods, has been explored in the adult HTR population, with findings to date suggesting that it may yield greater improvements in cardiorespiratory fitness compared with MICE. Exercise interventions, particularly HIIT interventions, have consistently shown clinically important improvements in exercise capacity in adult HTRs that are linked with improved long-term post-transplant outcomes and well-being. Unfortunately, trials of exercise interventions in pediatric HTRs remain lacking. This study team is proposing an assessment of the feasibility of a home-based HIIT exercise program using a novel telemedicine-enable video game linked customizable cycle ergometer (MedBIKE™).
Recruiting1 award N/A
High Intensity Interval Training
for Congenital Heart Disease
Congenital heart disease (CHD), the most common birth defect, is present in nearly 1% of the population. CHD patients are associated with intense resource utilization and premature death in adulthood. The risk of premature death is linked with reduced exercise capacity, a finding consistently noted in youth with CHD. Reduced exercise capacity in this population has also been associated with reduce physical activity and health-related quality of life. Cardiac rehabilitation (CR) in adults with acquired heart disease is an established secondary prevention strategy that improves exercise capacity. The investigators propose a prospective clinical trial of a home-based high intensity interval training (HIIT) program using a novel telemedicine-equipped video game-linked cycle ergometer (MedBIKE™) for 10 to 18 year olds with repaired moderate-complex CHD. The pilot study with the MedBIKE has shown promising results. The investigators now seek to study the efficacy of this program in a broader CHD population.
Recruiting1 award N/A2 criteria
More about Michael Khoury, MD
Clinical Trial Related2 years of experience running clinical trials · Led 3 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Michael Khoury, MD has experience with
- MedBIKE HIIT
Breakdown of trials Michael Khoury, MD has run
Acute Lymphoblastic Leukemia
Heart Transplant
Congenital Heart Defects
Congenital Heart Disease
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Michael Khoury, MD specialize in?
Michael Khoury, MD focuses on Acute Lymphoblastic Leukemia and Heart Transplant. In particular, much of their work with Acute Lymphoblastic Leukemia has involved treating patients, or patients who are undergoing treatment.
Is Michael Khoury, MD currently recruiting for clinical trials?
Yes, Michael Khoury, MD is currently recruiting for 2 clinical trials in Edmonton Alberta. If you're interested in participating, you should apply.
Are there any treatments that Michael Khoury, MD has studied deeply?
Yes, Michael Khoury, MD has studied treatments such as MedBIKE HIIT.
What is the best way to schedule an appointment with Michael Khoury, MD?
Apply for one of the trials that Michael Khoury, MD is conducting.
What is the office address of Michael Khoury, MD?
The office of Michael Khoury, MD is located at: University of Alberta, Edmonton, Alberta T6G 2B7 Canada. This is the address for their practice at the University of Alberta.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.