Dr. Reshma Amin, MD
Claim this profileThe Hospital for Sick Children
Studies Sleep Apnea
Studies Central Sleep Apnea
4 reported clinical trials
4 drugs studied
Affiliated Hospitals
Clinical Trials Reshma Amin, MD is currently running
Home-Initiated NiPPV
for Sleep Apnea
Children with medical complexity (CMC) often have trouble breathing at night and need to use a breathing machine. This breathing machine is called noninvasive positive pressure ventilation (NiPPV). The use of NiPPV has been shown to improve quality of life and survival in children. Before it is used, NiPPV must first be tested to see what the correct 'machine settings' are for each child. This is usually done in the sleep laboratory at the hospital during a one-night stay. However, sleep studies in the hospital are disruptive and hard for CMC and their families because of the new environment and limited access to the equipment, supplies, comfort items and the routine their child has at home. Patients and families would prefer to start NiPPV at home but there needs to be more research on this to make sure it is possible and safe. This study will evaluate a new model of care to start NiPPV in the home. CMC aged 5-17 years old and starting NiPPV will be assigned at random, like a coin toss, to start NiPPV in the home or to start NiPPV in the sleep laboratory. The investigators will assess the feasibility and safety of the two ways to start NiPPV. This study will be the first step towards developing a study to evaluate if home NiPPV starts are effective. Starting NiPPV at home has the potential to improve the use of NiPPV (ie early adherence predicts long-term use) resulting in both medical benefits as well as improved quality of life for CMC and their families.
Recruiting1 award N/A4 criteria
Medical Air vs Oxygen
for Prader-Willi Syndrome
The aim of this study is to determine if treatment with Medical Air (21% oxygen in room air) compared to supplemental oxygen (100% oxygen) will lead to similar improvements in the central apnea-hypopnea index (CAHI) for infants with Prader-Willi Syndrome. Despite the vast amount of research investigating the cause of central sleep apnea, there remain gaps in knowledge, lending to further research efforts. The decision to compare oxygen to medical air is based on several theorized mechanisms. The first of which is the supposition that provision of medical air may act as an arousal stimulus for the hypothalamus, thereby preventing sleep disordered breathing. Secondly, the hypercapnic challenge performed by Livingston et al demonstrated a delayed hypercapneic arousal response in PWS subjects despite simultaneous hyperoxia, leading us to question if therapeutic oxygen really plays a significant role in treating CSA. Lastly, the delivery of medical air via nasal prongs may provide sufficient arousal to terminate the cycle of events leading to central apnea, as described by Urquhart et al. A deeper understanding of central sleep apnea is essential to ameliorating its adverse sequelae, which include symptoms of ADHD, impaired attention, behavioral problems, and academic difficulties.
Recruiting3 awards Phase 42 criteria
More about Reshma Amin, MD
Clinical Trial Related1 year of experience running clinical trials · Led 4 trials as a Principal Investigator · 3 Active Clinical TrialsTreatments Reshma Amin, MD has experience with
- Medical Air Vs Oxygen
- Home Initiation Of NiPPV
- ATouchAway™ Platform
- The Virtual Peer Support Program
Breakdown of trials Reshma Amin, MD has run
Central Sleep Apnea
Prader-Willi Syndrome
Home Ventilator Therapy
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Reshma Amin, MD specialize in?
Reshma Amin, MD focuses on Sleep Apnea and Central Sleep Apnea. In particular, much of their work with Sleep Apnea has involved treating patients, or patients who are undergoing treatment.
Is Reshma Amin, MD currently recruiting for clinical trials?
Yes, Reshma Amin, MD is currently recruiting for 3 clinical trials in Toronto Ontario. If you're interested in participating, you should apply.
Are there any treatments that Reshma Amin, MD has studied deeply?
Yes, Reshma Amin, MD has studied treatments such as Medical Air vs Oxygen, Home Initiation of NiPPV, aTouchAway™ platform.
What is the best way to schedule an appointment with Reshma Amin, MD?
Apply for one of the trials that Reshma Amin, MD is conducting.
What is the office address of Reshma Amin, MD?
The office of Reshma Amin, MD is located at: The Hospital for Sick Children, Toronto, Ontario M5G 1X8 Canada. This is the address for their practice at the The Hospital for Sick Children.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.