Dr. Richard J Kovacs, MD
Claim this profileIndiana Clinical Research Center
Studies Atrial Fibrillation
Studies Long QT Syndrome
2 reported clinical trials
5 drugs studied
Affiliated Hospitals
Clinical Trials Richard J Kovacs, MD is currently running
Progesterone + Testosterone
for Long QT Syndrome
This research will determine if: 1) Oral progesterone attenuates drug-induced QT interval, J-Tpeak and Tpeak-Tend lengthening in postmenopausal women 50 years of age or older, and 2) Transdermal testosterone attenuates drug-induced QT interval, J-Tpeak and Tpeak-Tend lengthening in men 65 years of age or older. This investigation will consist of two concurrent prospective, randomized, double-blind, placebo-controlled crossover-design studies in a) Postmenopausal women, and b) Men 65 years of age or older. Study 1: Each postmenopausal woman will take progesterone or placebo capsules for 1 week. After a 14-day "washout" (no progesterone or placebo) each subject will then take the alternative therapy (progesterone or placebo) for 1 week. After 7 days of each treatment, subjects will present to the clinical research center to receive a small dose of the QT interval-lengthening drug ibutilide, and the effect on the QT, J-Tpeak and Tpeak-Tend intervals during the progesterone and placebo phases will be compared. Study 2: Each man 65 years of age or older will apply transdermal testosterone or transdermal placebo gel for 3 days. After a 7-day "washout" (no testosterone or placebo) each subject will then apply the alternative therapy (testosterone or placebo gel) for 1 week. After 3 days of each treatment, subjects will present to the clinical research center to receive a small dose of the QT interval-lengthening drug ibutilide, and the effect on the QT, J-Tpeak and Tpeak-Tend intervals during the testosterone and placebo phases will be compared.
Recruiting2 awards Phase 43 criteria
Ondansetron
for Atrial Fibrillation
"Afib" is a common irregular heartbeat. Afib can cause stroke, blood clots, dementia and death. Medicines used to treat Afib often do not work well and can cause serious side effects. Clinicians need medicines that work better for Afib. Medicines for Afib work by blocking a current in the heart called a potassium current. There is a newer potassium current called IKas that can contribute to Afib. A medicine called ondansetron is used to keep people with cancer from getting sick to their stomach and throwing up. The investigators have found that ondansetron blocks IKas, and the investigators think that this means that ondansetron may work well to treat Afib. So, in this study the investigators want to find out if ondansetron can: 1) Reduce the amount of time that people have Afib, and 2) Slow down the heart rate when people have Afib. The investigators will study 80 people who are scheduled to have an AF ablation. Several weeks prior to undergoing the ablation procedure, these AF patients will be assigned by chance (like flipping a coin) to one of two groups: ondansetron 8 mg by mouth twice daily or a sugar pill (placebo), which they will take for 28 days. The people in the study will not know whether they are receiving ondansetron or placebo. The investigators will find out if ondansetron reduces the percentage of time that people are in Afib. Also, the investigators will find out if ondansetron slows the heart rate while people are having Afib. The investigators will compare the people in the study who take ondansetron with the people in the study who take placebo. This research will help the investigators to find out if ondansetron can be used as a medicine for people who have Afib.
Recruiting2 awards Phase 43 criteria
More about Richard J Kovacs, MD
Clinical Trial Related3 years of experience running clinical trials · Led 2 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments Richard J Kovacs, MD has experience with
- Placebo
- Ondansetron
- Ibutilide
- Progesterone
- Testosterone
Breakdown of trials Richard J Kovacs, MD has run
Atrial Fibrillation
Long QT Syndrome
Side Effects
Abnormalities
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Richard J Kovacs, MD specialize in?
Richard J Kovacs, MD focuses on Atrial Fibrillation and Long QT Syndrome. In particular, much of their work with Atrial Fibrillation has involved treating patients, or patients who are undergoing treatment.
Is Richard J Kovacs, MD currently recruiting for clinical trials?
Yes, Richard J Kovacs, MD is currently recruiting for 2 clinical trials in Indianapolis Indiana. If you're interested in participating, you should apply.
Are there any treatments that Richard J Kovacs, MD has studied deeply?
Yes, Richard J Kovacs, MD has studied treatments such as Placebo, Ondansetron, Ibutilide.
What is the best way to schedule an appointment with Richard J Kovacs, MD?
Apply for one of the trials that Richard J Kovacs, MD is conducting.
What is the office address of Richard J Kovacs, MD?
The office of Richard J Kovacs, MD is located at: Indiana Clinical Research Center, Indianapolis, Indiana 46202 United States. This is the address for their practice at the Indiana Clinical Research Center.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.