Dr. Rudolf Uher, MD
Claim this profileNova Scotia Health Authority
Studies Depression
Studies Bipolar Disorder
5 reported clinical trials
6 drugs studied
Affiliated Hospitals
Clinical Trials Rudolf Uher, MD is currently running
CBT + Antidepressants
for Depression
Depression currently affects close to 2 million Canadians and is the leading cause of disability worldwide. Pharmacological treatments (antidepressant medication) and psychological treatments such as cognitive-behavioural therapy are available for depression, but the majority of those who receive treatment have an unsatisfactory response. On average, the combination of pharmacological and psychological treatment achieves better results than either treatment alone. However, the apparently superior results of combination treatment may be due to the fact that different individuals preferentially respond to pharmacological or psychological treatment. The invesitagtors have discovered several clinical factors and biomarkers that predict poor response to commonly used antidepressant medication: history of childhood maltreatment, loss of interest and reduced activity, a biomarker of systemic inflammation, and a genetic marker of sensitivity to environment. Indirect evidence suggests that the same factors may indicate the need for psychological treatment, but their usefulness as differential predictors of psychological and pharmacological treatment outcomes remains to be established. The investigators will test the hypothesis that a pre-determined set of clinical variables (history of childhood maltreatment, loss of interest and reduced activity) and biomarkers (serum C-reactive protein, a marker of systemic inflammation, and short alleles of the serotonin transporter gene promoter polymorphism) differentially predicts response to antidepressants and to cognitive-behavioural psychotherapy with clinically significant accuracy. If this hypothesis is supported, the resulting predictor will allow personalized selection of treatment for depression, leading to improved outcomes and healthcare efficiency. Additional objectives include replication of additional predictors and integrative analyses aimed at refining the treatment choice algorithms.
Recruiting3 awards Phase 4
Mindfulness and CBT
for Preventing Severe Mental Illness in Youth
Severe mental illness such as schizophrenia and mood disorders typically develops at a young age and can cause life-long disability. Currently available treatments cannot cure severe mental illness. This makes it important to find ways to prevent severe mental illness in young people before it has a chance to develop. This research study will pilot a new preventive intervention for young people who are at high risk of developing severe mental illness. The investigators will target early preceding factors (the 'antecedents') to severe mental illness which includes anxiety, unusual hearing and visual experiences, the loss of previously acquired abilities, and sudden and unpredictable changes in mood. These antecedents strongly predict an increased risk of developing severe mental illness. They are often impairing and distressing to the individual but can be improved with self-management skills and parent training, and they are present in the individual years before the onset of severe mental illness which makes them an ideal target for early intervention. The goal is to intervene early enough in the young person's life that severe mental illness can be prevented, hopefully leading to a happy, healthy and productive adulthood. The investigators want to test the acceptability and short-term efficacy of this new preventive intervention.
Recruiting1 award N/A
More about Rudolf Uher, MD
Clinical Trial Related7 years of experience running clinical trials · Led 5 trials as a Principal Investigator · 5 Active Clinical TrialsTreatments Rudolf Uher, MD has experience with
- MaCBT
- Genetic Counselling
- Cognitive Behavioral Therapy
- Antidepressants
- Escitalopram
- Brexpiprazole
Breakdown of trials Rudolf Uher, MD has run
Depression
Bipolar Disorder
Major Depressive Disorder
Schizophrenia
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Rudolf Uher, MD specialize in?
Rudolf Uher, MD focuses on Depression and Bipolar Disorder. In particular, much of their work with Depression has involved treating patients, or patients who are undergoing treatment.
Is Rudolf Uher, MD currently recruiting for clinical trials?
Yes, Rudolf Uher, MD is currently recruiting for 4 clinical trials in Halifax Nova Scotia. If you're interested in participating, you should apply.
Are there any treatments that Rudolf Uher, MD has studied deeply?
Yes, Rudolf Uher, MD has studied treatments such as maCBT, Genetic counselling, Cognitive Behavioral Therapy.
What is the best way to schedule an appointment with Rudolf Uher, MD?
Apply for one of the trials that Rudolf Uher, MD is conducting.
What is the office address of Rudolf Uher, MD?
The office of Rudolf Uher, MD is located at: Nova Scotia Health Authority, Halifax, Nova Scotia B3H 2E2 Canada. This is the address for their practice at the Nova Scotia Health Authority.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.