Dr. Seth E. Karol, MD
Claim this profileSt. Jude Children's Research Hospital
Studies Childhood Cancer
Studies Acute Lymphoblastic Leukemia
10 reported clinical trials
17 drugs studied
Area of expertise
1Childhood Cancer
BCR-ABL1 positive
FLT3 negative
BCR-ABL1 T315I positive
2Acute Lymphoblastic Leukemia
BCR-ABL1 positive
BCR-ABL1 T315I positive
Trisomy 21 positive
Affiliated Hospitals
Clinical Trials Seth E. Karol, MD is currently running
Diagnostic Testing
for Pediatric Leukemia
This study aims to use clinical and biological characteristics of acute leukemias to screen for patient eligibility for available pediatric leukemia sub-trials. Testing bone marrow and blood from patients with leukemia that has come back after treatment or is difficult to treat may provide information about the patient's leukemia that is important when deciding how to best treat it, and may help doctors find better ways to diagnose and treat leukemia in children, adolescents, and young adults.
Recruiting1 award Phase 1 & 211 criteria
Selinexor + Venetoclax + Chemotherapy
for Acute Myeloid Leukemia
The purpose of this study is to test the safety and determine the best dose of venetoclax and selinexor when given with chemotherapy drugs in treating pediatric and young adult patients with acute myeloid leukemia (AML) or acute leukemia of ambiguous lineage (ALAL) that has come back (relapsed) or did not respond to treatment (refractory). Primary Objective * To determine the safety and tolerability of selinexor and venetoclax in combination with chemotherapy in pediatric patients with relapsed or refractory AML or ALAL. Secondary Objectives * Describe the rates of complete remission (CR) and complete remission with incomplete count recovery (CRi) for patients treated with selinexor and venetoclax in combination with chemotherapy at the recommended phase 2 dose (RP2D). * Describe the overall survival of patients treated at the RP2D. Exploratory Objectives * Explore associations between leukemia cell genomics, BCL2 family member protein quantification, BH3 profiling, and response to therapy as assessed by minimal residual disease (MRD) and variant clearance using cell-free deoxyribonucleic acid (DNA) (cfDNA). * Describe the quality of life of pediatric patients undergoing treatment with selinexor and venetoclax in combination with chemotherapy and explore associations of clinical factors with patient-reported quality of life outcomes. * Describe the clinical and genetic features associated with exceptional response to the combination of venetoclax and selinexor without the addition of chemotherapy.
Recruiting1 award Phase 1
More about Seth E. Karol, MD
Clinical Trial Related2 years of experience running clinical trials · Led 10 trials as a Principal Investigator · 4 Active Clinical TrialsTreatments Seth E. Karol, MD has experience with
- Venetoclax
- Methotrexate
- Cytarabine
- Fludarabine
- Selinexor
- Intensive Antihypertensive Therapy
Breakdown of trials Seth E. Karol, MD has run
Childhood Cancer
Acute Lymphoblastic Leukemia
Lymphoma
Acute Leukemia
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Seth E. Karol, MD specialize in?
Seth E. Karol, MD focuses on Childhood Cancer and Acute Lymphoblastic Leukemia. In particular, much of their work with Childhood Cancer has involved BCR-ABL1 positive patients, or patients who are FLT3 negative.
Is Seth E. Karol, MD currently recruiting for clinical trials?
Yes, Seth E. Karol, MD is currently recruiting for 4 clinical trials in Memphis Tennessee. If you're interested in participating, you should apply.
Are there any treatments that Seth E. Karol, MD has studied deeply?
Yes, Seth E. Karol, MD has studied treatments such as Venetoclax, Methotrexate, Cytarabine.
What is the best way to schedule an appointment with Seth E. Karol, MD?
Apply for one of the trials that Seth E. Karol, MD is conducting.
What is the office address of Seth E. Karol, MD?
The office of Seth E. Karol, MD is located at: St. Jude Children's Research Hospital, Memphis, Tennessee 38105 United States. This is the address for their practice at the St. Jude Children's Research Hospital.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.