Dr. Stephen N. Davis, MBBS
Claim this profileUniversity of Maryland, Baltimore
Studies Diabetes
Studies Postprandial Metabolism
5 reported clinical trials
9 drugs studied
Affiliated Hospitals
Clinical Trials Stephen N. Davis, MBBS is currently running
Fluoxetine + DHEA
for Type 1 Diabetes
(1) To determine how the Selective Serotonin Reuptake Inhibitor (SSRI), fluoxetine (Prozac), an antidepressant often used to treat depression, stimulates the participant's body's ability to defend against low blood sugar (hypoglycemia). (2) To learn how a hormone, dehydroepiandrosterone (DHEA), stimulates the participant's body's ability to defend itself from low blood sugar (hypoglycemia). DHEA is a hormone produced naturally in the human body. However, it can be manufactured and is sold as an over-the-counter dietary supplement. The dose the investigators are giving in this study is higher than the usual recommended dosage taken as a supplement for certain medical conditions. (3) To study combined effects of fluoxetine and DHEA during low blood glucose. In the present study, the investigators will measure the participant's body's responses to hypoglycemia when given fluoxetine or DHEA or fluoxetine and DHEA or a placebo (a pill with no fluoxetine or DHEA). Approximately 64 individuals with type 1 diabetes will take part in this study.
Recruiting0 awards Phase < 14 criteria
Fluoxetine
for Type 1 Diabetes
Exercise is a cornerstone of diabetes management. It helps reduce blood pressure, promote weight loss, lower insulin resistance and improve glucose and lipid (triglyceride and HDL-cholesterol) profiles. Unfortunately, the benefits of exercise are often not embraced by diabetic individuals because of the fear of low blood sugar (hypoglycemia). My laboratory has demonstrated that Autonomic nervous system (ANS) counterregulatory failure plays an important role in exercise associated hypoglycemia in Type 1 DM. ANS responses are significantly reduced in Type 1 DM and are further blunted by antecedent episodes of hypoglycemia. Furthermore, there is a large sexual dimorphism of reduced ANS responses during submaximal exercise in both Type 1 DM and healthy individuals that is unexplained. Accumulating data are demonstrating that serotonergic pathways can regulate ANS discharge. Generally, serotonergic pathways are inhibitory but both single and longer term administration of selective serotonin reuptake inhibitors (SSRI's) such as Prozac has been demonstrated to increase basal epinephrine levels and enhance baroreflex control of Sympathetic nervous system (SNS) activity. What is unknown is whether fluoxetine can also enhance SNS responses and also override the large ANS sexual dimorphism present during sub maximal exercise. Therefore, the purpose of this study is to determine if the SSRI fluoxetine (Prozac) can improve SNS responses during exercise.
Recruiting0 awards Phase < 16 criteria
More about Stephen N. Davis, MBBS
Clinical Trial Related7 years of experience running clinical trials · Led 5 trials as a Principal Investigator · 4 Active Clinical TrialsTreatments Stephen N. Davis, MBBS has experience with
- Fluoxetine
- DHEA
- Fluoxetine And DHEA
- Placebo Oral Tablet
- Placebo Control
- Glucagon-Like Peptide-1 (GLP-1)
Breakdown of trials Stephen N. Davis, MBBS has run
Postprandial Metabolism
Autonomic Failure
Reactive Hypoglycemia
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does Stephen N. Davis, MBBS specialize in?
Stephen N. Davis, MBBS focuses on Diabetes and Postprandial Metabolism. In particular, much of their work with Diabetes has involved treating patients, or patients who are undergoing treatment.
Is Stephen N. Davis, MBBS currently recruiting for clinical trials?
Yes, Stephen N. Davis, MBBS is currently recruiting for 4 clinical trials in Baltimore Maryland. If you're interested in participating, you should apply.
Are there any treatments that Stephen N. Davis, MBBS has studied deeply?
Yes, Stephen N. Davis, MBBS has studied treatments such as Fluoxetine, DHEA, Fluoxetine and DHEA.
What is the best way to schedule an appointment with Stephen N. Davis, MBBS?
Apply for one of the trials that Stephen N. Davis, MBBS is conducting.
What is the office address of Stephen N. Davis, MBBS?
The office of Stephen N. Davis, MBBS is located at: University of Maryland, Baltimore, Baltimore, Maryland 21201 United States. This is the address for their practice at the University of Maryland, Baltimore.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.