Dr. William W Stoops, Ph.D.
Claim this profileUniversity of Kentucky
Studies Cocaine Use Disorder
Studies Opioid Dependence
3 reported clinical trials
8 drugs studied
Affiliated Hospitals
Clinical Trials William W Stoops, Ph.D. is currently running
n-Acetylcysteine
for Substance Use Disorder
The overarching hypotheses of this protocol are that (1) persistent brain glutamate changes induced by chronic opioid use will exacerbate use of cocaine during opioid physical dependence and withdrawal and (2) n-acetylcysteine (NAC) will ameliorate glutamatergic dysregulation, and thus will reduce both opioid and cocaine demand. These hypotheses will be tested with two specific aims. Specific Aim 1. Determine the reinforcing effects of cocaine in individuals with comorbid opioid and cocaine use disorder with physiological dependence on opioids during NAC maintenance. All subjects will be maintained on oral hydromorphone. They will also be randomly assigned to receive placebo or oral NAC (2.4 g/day), stratified by sex. After dose stabilization, experimental sessions will be conducted in which subjects complete hypothetical cocaine purchase tasks during opioid maintenance and opioid withdrawal. The hypotheses are: 1) cocaine purchasing will be greater during opioid withdrawal and 2) NAC maintenance will attenuate cocaine purchasing across opioid maintenance and withdrawal periods. Specific Aim 2. Evaluate glutamate functionality during periods of opioid maintenance and withdrawal in individuals with comorbid opioid and cocaine use disorder and physiological dependence on opioids during NAC maintenance. Subjects will undergo magnetic resonance spectroscopy to evaluate brain glutamate changes as a function of opioid maintenance/withdrawal state and NAC maintenance. The hypotheses are: 1) glutamate levels will be elevated during opioid withdrawal and 2) NAC maintenance will ameliorate elevated glutamate levels.
Recruiting0 awards Phase < 1
Suvorexant
for Alcoholism
This research will translate findings from preclinical research and provide the initial clinical evidence that orexin antagonism reduces motivation for alcohol, as well as other alcohol-associated maladaptive behaviors in people with Alcohol Use Disorder. This study will also provide basic science information about the orexinergic mechanisms underlying the pharmacodynamic effects of alcohol in humans. As such, the outcomes will contribute to our understanding of the clinical neurobiology of Alcohol Use Disorder. Overall, the proposed work seeks to expand the scope of current clinical neuroscience research on alcohol addiction by focusing on orexin, which has strong preclinical evidence supporting its critical role in addiction but remains unstudied in humans.
Recruiting0 awards Phase < 1
More about William W Stoops, Ph.D.
Clinical Trial Related2 years of experience running clinical trials · Led 3 trials as a Principal Investigator · 2 Active Clinical TrialsTreatments William W Stoops, Ph.D. has experience with
- Hydromorphone
- N-acetylcysteine
- N-acetylcystine
- Placebo Hydromorphone
- Placebo N-acetylcystine
- Suvorexant
Breakdown of trials William W Stoops, Ph.D. has run
Cocaine Use Disorder
Opioid Dependence
Opioid Use Disorder
Alcoholism
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Frequently asked questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the ‘trial drug’ — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
What does William W Stoops, Ph.D. specialize in?
William W Stoops, Ph.D. focuses on Cocaine Use Disorder and Opioid Dependence. In particular, much of their work with Cocaine Use Disorder has involved treating patients, or patients who are undergoing treatment.
Is William W Stoops, Ph.D. currently recruiting for clinical trials?
Yes, William W Stoops, Ph.D. is currently recruiting for 2 clinical trials in Lexington Kentucky. If you're interested in participating, you should apply.
Are there any treatments that William W Stoops, Ph.D. has studied deeply?
Yes, William W Stoops, Ph.D. has studied treatments such as Hydromorphone, n-acetylcysteine, n-acetylcystine.
What is the best way to schedule an appointment with William W Stoops, Ph.D.?
Apply for one of the trials that William W Stoops, Ph.D. is conducting.
What is the office address of William W Stoops, Ph.D.?
The office of William W Stoops, Ph.D. is located at: University of Kentucky, Lexington, Kentucky 40507 United States. This is the address for their practice at the University of Kentucky.
Is there any support for travel costs?
The coverage of travel expenses can vary greatly between different clinical trials. Please see more financial detail in the trials you’re interested to apply.