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Micardis vs Lisinopril
Introduction
For patients with hypertension, also known as high blood pressure, certain medications can help in managing this condition by influencing various mechanisms involved within the cardiovascular system. Micardis and Lisinopril are two such drugs that are commonly prescribed for maintaining blood pressure levels. These medications each impact different physiological pathways but have a common goal of reducing elevated blood pressure. Micardis is an angiotensin receptor blocker (ARB) which works by obstructing the action of a natural substance that narrows the blood vessels, thus helping to relax and dilate them for easier blood flow. On the other hand, Lisinopril belongs to a class of drugs called ACE inhibitors (angiotensin-converting enzyme inhibitors), which primarily work by relaxing arteries and veins while reducing volumes of some substances in your body that can raise your blood pressure.
Micardis vs Lisinopril Side By Side
| Attribute | Micardis | Lisinopril |
|---|---|---|
| Brand Name | Micardis | Lisinopril |
| Contraindications | Should not be taken with aliskiren especially in patients with diabetes or kidney impairment. Not to be used during pregnancy. | Should not be taken with aliskiren especially in patients with diabetes or kidney impairment. Not to be used during pregnancy. |
| Cost | Brand: ~$125 for 30 tablets (40 mg), Generic: ~$0.50 to $0.90 per day | Brand: ~$100 for 30 tablets (20 mg), Generic: ~$0.03 to $0.60 per day |
| Generic Name | Telmisartan | Lisinopril |
| Most Serious Side Effect | Signs of an allergic reaction, kidney problems, low blood pressure, high potassium levels | Severe allergic reactions, kidney problems, liver issues, high potassium levels |
| Severe Drug Interactions | Aliskiren, especially in patients with diabetes or kidney impairment | Aliskiren, especially in patients with diabetes or kidney impairment |
| Typical Dose | 20-80 mg/day | 10-40 mg/day |
What is Micardis?
Micardis (also known as Telmisartan) belongs to a class of drugs called Angiotensin Receptor Blockers (ARBs), which marked a significant advancement from the first-line treatment for high blood pressure, ACE inhibitors like Lisinopril. Micardis was first approved by the FDA in 1998. It works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and keeping your blood pressure at an optimum level. Micardis is used primarily for treating hypertension but can also be prescribed for reducing cardiovascular risks in patients who cannot take ACE inhibitors.
On another note, Lisinopril is well-known as it has been around longer and has widespread use; however, it may cause side effects such as coughing which are not common with ARBs like Micardis. These medications have similar efficacy regarding lowering blood pressure; nevertheless, individual responses may vary depending on various factors including patient's condition and their body's response to medication.
What conditions is Micardis approved to treat?
Micardis is approved for the treatment of several cardiovascular conditions:
- Hypertension, commonly known as high blood pressure
- Cardiovascular risk reduction in patients unable to take ACE inhibitors
- Post-myocardial infarction (heart attack), in combination with standard treatments such as thrombolytics, beta-blockers, and statins.
How does Micardis help with these illnesses?
Micardis helps to manage hypertension by blocking the action of angiotensin II, a chemical in your body that causes muscles in most arteries, including the arteries of the heart, to contract thereby narrowing your blood vessels and elevating your blood pressure. Micardis belongs to a class of drugs known as angiotensin receptor blockers (ARBs) which work by relaxing blood vessels so that blood can flow more easily. This helps lower high blood pressure and reduces strain on the heart.
Lisinopril works similarly but through a different mechanism. It is part of a class of medications called ACE inhibitors, which block an enzyme in your body from producing angiotensin II. Like Micardis, Lisinopril also results in relaxation and widening of the blood vessels leading to decreased blood pressure levels.
Both these medications are effective for managing high blood pressure but their suitability may depend upon individual health conditions or side-effect profiles.
What is Lisinopril?
Lisinopril, marketed under various brand names including Prinivil and Zestril, is an angiotensin-converting enzyme (ACE) inhibitor. It functions by blocking the conversion of angiotensin I to angiotensin II in the body. This process leads to vasodilation, a reduction in fluid volume, and ultimately a decrease in blood pressure. Lisinopril was first approved by the FDA in 1987.
As Lisinopril does not belong to the class of sartans (like Micardis), it has a different mechanism of action and side effect profile. One key difference is that ACE inhibitors like Lisinopril can cause dry cough - a side effect not seen with sartans such as Micardis. However, it does not typically cause hyperkalemia or significant changes in renal function which are possible adverse effects associated with drugs like Micardis.
The beneficial effects on blood pressure make Lisinopril particularly useful for patients suffering from hypertension or certain types of heart conditions where lowering blood pressure is essential.
What conditions is Lisinopril approved to treat?
Lisinopril is an ACE inhibitor that has been approved by the FDA for various conditions, including:
- Hypertension (high blood pressure)
- Heart failure
- Acute myocardial infarction (heart attack) to improve survival and decrease heart failure symptoms.
How does Lisinopril help with these illnesses?
Lisinopril is an angiotensin converting enzyme (ACE) inhibitor that acts primarily on the renin-angiotensin system, a hormone system that regulates blood pressure and fluid balance. By inhibiting ACE, Lisinopril decreases levels of angiotensin II, thereby relaxing arterial muscle and enlarging arteries. This reduces blood pressure and increases the efficiency of the heart by increasing its capacity to carry oxygen-rich blood to bodily tissues.
Unlike Micardis which is an angiotensin receptor blocker (ARB), Lisinopril works earlier in the rennin-angiotense process providing more thorough regulation of this key body system. Therefore, it may be prescribed when a patient does not respond well to ARBs or may be combined with them for better overall control of hypertension.
How effective are both Micardis and Lisinopril?
Both telmisartan (Micardis) and lisinopril have a proven track record in treating patients with hypertension, and their initial FDA approvals were only a few years apart. They both work to lower blood pressure, but they do so by different mechanisms - lisinopril is an ACE inhibitor while telmisartan is an angiotensin receptor blocker (ARB). A 2004 clinical trial compared the effectiveness of these two drugs directly; both exhibited similar efficacy in managing symptoms of hypertension as well as promising safety profiles.
A review published in 2016 reported that lisinopril has been effective at controlling high blood pressure from the first week of treatment, its side effect profile being comparable or even superior to many other antihypertensive medications. This study also noted that Lisinopril had excellent patient tolerance including elderly populations. The dose showing optimal efficacy was determined to be between 10-40 mg/day depending on individual patient needs.
Telmisartan's effectiveness was assessed in a meta-analysis published in 2017 which indicated it appears more effective than placebo for reducing high blood pressure and demonstrated similar efficacy when compared with other commonly used antihypertensive medications. Although typically considered after ACE inhibitors like Lisinopril or calcium channel blockers due to cost considerations, Telmisartan exhibits unique pharmacological properties such as longer half-life leading to better control over 24 hours period which makes it a valuable alternative treatment option especially for those who did not respond adequately or experienced unacceptable side effects with first-line treatments.
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At what dose is Micardis typically prescribed?
Oral dosages of Micardis typically range from 20-80 mg/day, but research shows that even a 20 mg/day dose can effectively manage high blood pressure in most adults. For Lisinopril, the usual starting dosage is 10 mg/day for adults. Depending on how patients respond to these medications, their doctor may choose to increase the dosage after a few weeks. However, it's crucial not to exceed the maximum recommended daily dose: 80 mg for Micardis and up to 40 mg for Lisinopril.
At what dose is Lisinopril typically prescribed?
Lisinopril therapy usually begins at a dose of 10 mg per day. Depending on the patient's response to the treatment, this dosage can then be increased gradually to 20-40 mg/day, divided into two doses and taken 12 hours apart. The maximum recommended dose is 80 mg/day, which could be split into two doses of 40 mg each or four doses of 20 mg each and spaced out evenly throughout the day. If there is no significant improvement in blood pressure levels after a few weeks at an initial lower dosage, your doctor may consider increasing it up incrementally until desired results are achieved.
What are the most common side effects for Micardis?
Common side effects of Micardis include:
- Headache
- Dizziness, lightheadedness
- Fatigue (general weakness and tiredness)
- Back pain
- Nasal congestion
- Sinusitis (inflammation of the sinus cavities in the head)
- Diarrhea
- Nausea
While frequent side effects from Lisinopril comprise:
- Cough
- Dizziness, severe drowsiness or light-headed feeling particularly while standing up quickly
- Headaches
-Diarrhea -Nausea, vomiting
-Rash or itching
-Chest pain
Please consult with your healthcare provider if you experience any persistent symptoms or discomfort.
Are there any potential serious side effects for Micardis?
While both Micardis and Lisinopril are used to control high blood pressure, they do have different side effects. It's important to be aware of these potential issues:
- Signs of an allergic reaction such as hives, difficulty breathing or swallowing, swelling in your face or throat
- Symptoms indicating a change in the amount of urine: this could mean kidney problems
- Lightheadedness or fainting spells: these can suggest low blood pressure
- A rapid, pounding heartbeat or a slow heartbeat
- Excessive thirst with headache, nausea, vomiting, weakness and confusion; these signs might indicate high potassium levels in your body.
For Lisinopril specifically:
- Dizziness when standing up quickly from lying down position - due to lower sodium levels.
- Feverish feelings with muscle stiffness and confusion may point towards severe nervous system reactions.
If you experience any of these symptoms after taking Micardis or Lisinopril it is crucial that you consult with your healthcare provider immediately.
What are the most common side effects for Lisinopril?
Lisinopril, a commonly prescribed medication for high blood pressure, can cause the following side effects:
- Dry cough
- Dizziness and lightheadedness due to low blood pressure
- Headache
- Persistent nausea or vomiting
- Severe stomach/abdominal pain
- Yellowing eyes or skin (jaundice)
- Dark urine
- Fatigue and fainting spells
- High potassium levels leading to symptoms like muscle weakness, slow heart rate. It's important to note that Lisinopril could also lead to allergic reactions in some people who might experience symptoms such as swelling of the face/lips/tongue/throat and difficulty breathing.
Are there any potential serious side effects for Lisinopril?
Lisinopril, while generally safe and effective for managing high blood pressure, may cause certain serious side effects in rare cases. You should seek immediate medical attention if you experience any of the following:
- Signs of a severe allergic reaction: facial swelling, difficulty breathing or swallowing
- Irregular heartbeats
- Symptoms related to kidney problems such as change in the amount of urine produced
- Yellowing eyes/skin - indicating potential liver issues
- Severe dizziness or fainting spells
- High potassium levels which can lead to feelings of weakness or irregular heartbeat.
These symptoms could be indicative of more critical health concerns that need immediate attention. If you encounter these signs after taking Lisinopril, it's crucial that you contact your healthcare provider promptly.
Contraindications for Micardis and Lisinopril?
Both Micardis and Lisinopril, like most other hypertension medications, may cause certain side effects. If you notice your blood pressure dropping too low or experience symptoms such as dizziness, lightheadedness or fainting spells, seek immediate medical attention.
Neither Micardis nor Lisinopril should be taken if you are using aliskiren (a renin inhibitor) especially in the case of diabetes or kidney impairment. Always inform your physician about all medications currently being used; since renin inhibitors could interact dangerously with both Micardis and Lisinopril.
Also note that these drugs should not be taken during pregnancy due to the potential risk to the fetus. Consult with your healthcare provider for more details on managing high blood pressure during pregnancy.
How much do Micardis and Lisinopril cost?
When comparing the costs of brand name versions of Micardis and Lisinopril:
- The price for 30 tablets of Micardis (40 mg) averages around $125, which works out to approximately $4.16 per day.
- In contrast, the price for 30 tablets of Zestril (20 mg), a brand name version of lisinopril, averages about $100 or roughly $3.33 per day.
Thus, if you are in the regular dosage range for these medications, brand-name Zestril is less expensive on a per-day basis than Micardis. As always though, cost should not be your primary consideration when deciding between these two drugs.
For generic versions:
- Generic telmisartan (the active ingredient in Micardis) can lower this daily cost significantly with prices averaging around $0.50 to $.90 per day depending upon your dose.
- Likewise generic lisinopril can cost even less - from as low as $0.03 up to about $.60/day depending on where it's purchased and whether you opt for larger packs that offer volume discounts.
Remember: while costs may influence decisions about medication options when all else is equal - efficacy and side-effect profiles must also factor into any decisions made regarding treatment plans!
Popularity of Micardis and Lisinopril
Telmisartan, in generic form as well as brand names such as Micardis, was estimated to have been prescribed to about 1.3 million people in the US in 2020. Telmisartan accounted for just over 5% of angiotensin receptor blocker (ARB) prescriptions in the US and is typically used when patients are intolerant or unresponsive to ACE inhibitors like Lisinopril. The prevalence of telmisartan has remained steady since its introduction.
Lisinopril, including brand versions such as Prinivil and Zestril, was prescribed to a staggering 87.4 million people in the USA in 2020 making it one of the most commonly used drugs overall. In the US, lisinopril accounts for approximately half of all ACE inhibitor prescriptions and almost a quarter of all blood pressure medication prescriptions overall. The use of lisinopril has seen an increase over time due to its proven effectiveness and safety profile.
Conclusion
Both Micardis (telmisartan) and Lisinopril have long-standing records of usage in patients with hypertension, and they're backed by numerous clinical studies indicating that they are more effective than placebo treatments. In some cases, the drugs may be used together to control high blood pressure but this is subject to careful consideration by a physician due to their different mechanisms of action: Micardis acts primarily as an angiotensin receptor blocker while Lisinopril inhibits the enzyme involved in producing angiotensin II.
Micardis is generally considered when patients cannot tolerate ACE inhibitors like Lisinopril or need additional blood pressure reduction. However, Lisinopril is often chosen as a first-line treatment option for hypertension due its efficacy and affordability since it's available in generic form which represents significant cost savings especially for patients who must pay out of pocket.
The side effect profile differs between these two drugs; while both are usually well-tolerated, common side effects of Lisinopril include cough and risk of hyperkalemia (high potassium levels), whereas Micardis can lead to dizziness and upper respiratory tract infections. For both medications, regular monitoring of kidney function tests and electrolytes is crucial especially when starting treatment, so any potential adverse effects can be promptly addressed.