Topical Tranexamic Acid for Wrist Fractures
(TRADR Trial)

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase 4

Waitlist Available

Sponsor: University Health Network, Toronto

Prior Safety Data

Trial Summary

What is the purpose of this trial?The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo).

Eligibility Criteria

This trial is for individuals who are undergoing surgery for a wrist fracture. It aims to see if applying tranexamic acid (TXA) directly into the wound can reduce pain and improve wrist function post-surgery compared to a placebo.

Inclusion Criteria

Provision of informed consent

I am 18 years old or older.

Cognitive ability and English-language skills required to complete outcome measures

+1 more

Exclusion Criteria

I have a chronic pain condition, fibromyalgia, or polymyalgia rheumatica.

I had surgery on my wrist from the back of my hand.

Known allergic reaction to TXA

+8 more

Participant Groups

The study is testing topical tranexamic acid (TXA), applied to the surgical site, against a placebo. The focus is on measuring differences in post-operative pain, use of painkillers, and recovery of wrist function between the two groups.

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Topical TRanexamic AcidExperimental Treatment1 Intervention

10mL of 100mg/mL TXA in addition to the standard care

Group II: PlaceboPlacebo Group1 Intervention

10mL of 100mg/mL normal saline in addition to the standard care