Cevimeline Hydrochloride

Xerostomia

Treatment

2 FDA approvals

0 Active Studies for Cevimeline Hydrochloride

What is Cevimeline Hydrochloride

Cevimeline

The Generic name of this drug

Treatment Summary

Cevimeline is a drug used to treat dry mouth caused by Sjögren's syndrome. It works by stimulating certain receptors in the body that help increase the production of saliva. It has been approved by the FDA for use in treating this condition.

Evoxac

is the brand name

image of different drug pills on a surface

Cevimeline Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Evoxac

Cevimeline

2000

14

Approved as Treatment by the FDA

Cevimeline, also known as Evoxac, is approved by the FDA for 2 uses including Xerostomia and Sjogren's Syndrome (SS) .

Xerostomia

Sjogren's Syndrome (SS)

Effectiveness

How Cevimeline Hydrochloride Affects Patients

Cevimeline is a drug that stimulates the muscarinic receptors in the body. When taken in the right amount, it can increase saliva and sweat production, as well as increase the strength of muscles in the digestive and urinary systems.

How Cevimeline Hydrochloride works in the body

Cevimeline is a drug that works by activating two types of muscarinic receptors in the body. The first type is found in secretory glands, and when stimulated, it increases the amount of fluids secreted. The second type is found in smooth muscle and glands, and when stimulated, it causes the muscles to contract and increases the amount of fluids secreted. This helps to relieve the symptoms of dry mouth.

When to interrupt dosage

The measure of Cevimeline Hydrochloride is contingent upon the diagnosed affliction. The amount of dosage is likewise variable, in consideration of the technique of delivery outlined in the table beneath.

Condition

Dosage

Administration

Xerostomia

30.0 mg,

, Oral, Capsule, Capsule - Oral

Warnings

There are 20 known major drug interactions with Cevimeline Hydrochloride.

Common Cevimeline Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Cevimeline.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Cevimeline.

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Cevimeline.

Clomipramine

Major

The metabolism of Clomipramine can be decreased when combined with Cevimeline.

Clonidine

Major

The metabolism of Clonidine can be decreased when combined with Cevimeline.

image of a doctor in a lab doing drug, clinical research

Cevimeline Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Cevimeline Hydrochloride?

8 active investigations are assessing the potential of Cevimeline Hydrochloride to alleviate symptoms of Sjögren's Syndrome.

Condition

Clinical Trials

Trial Phases

Xerostomia

0 Actively Recruiting

Cevimeline Hydrochloride Reviews: What are patients saying about Cevimeline Hydrochloride?

5

Patient Review

10/28/2015

Cevimeline Hydrochloride for Dry Mouth Secondary to Sjogren's Syndrome

This treatment has been a lifesaver for me. After being diagnosed with sjogrens, I was so depressed over the dry mouth and horrible breath issues. Rhuemy prescribed Cevimeline HCL 30mg 3x/day. WOW!!!! Now I can speak with out a dry mouth and it even seems to be helping my eyes. I have been on it less than 8 mos, but I have only one side effect-sometimes I get up 2-3x at night to go urinate. The pill seems to create water all over for me. Small price to pay for a normal-feeling

5

Patient Review

1/3/2013

Cevimeline Hydrochloride for Dry Mouth Secondary to Sjogren's Syndrome

This treatment really helped me. I'm grateful for modern medicine.

4.7

Patient Review

1/9/2009

Cevimeline Hydrochloride for Dry Mouth Secondary to Sjogren's Syndrome

4.3

Patient Review

4/16/2021

Cevimeline Hydrochloride for Dry Mouth Secondary to Sjogren's Syndrome

I followed the doctor's orders and took this medication three times a day. I'm really happy with how it's helped me, especially since it didn't cause any bothersome side effects.

4

Patient Review

10/9/2021

Cevimeline Hydrochloride for Dry Mouth Secondary to Sjogren's Syndrome

I just realized that most of my symptoms are caused by Cevimaline. But it's great for hydrating your mouth. My eyes need more help, though. increased urination can also be a problem, so be careful about dehydration. Makes talking much easier--until you realize you're spraying saliva all over!

3.7

Patient Review

6/11/2015

Cevimeline Hydrochloride for Dry Mouth Secondary to Sjogren's Syndrome

This medicine has helped my dry mouth a lot, but I've been having problems with a lot of itching. It's terrible, and I don't want to give up the medication because the doctor says that isn't a side effect. But I'm sure it is. I don't know what to do.

3.3

Patient Review

3/15/2015

Cevimeline Hydrochloride for Dry Mouth Secondary to Sjogren's Syndrome

I unfortunately got very dizzy and sick to my stomach after starting this medication. Has anyone else had a similar experience? I'm curious if there are other options out there that might work better for me.

3

Patient Review

3/15/2010

Cevimeline Hydrochloride for Osteoporosis

Unfortunately, this didn't work for me. I had a severe reaction after taking just one pill.

1.7

Patient Review

8/30/2009

Cevimeline Hydrochloride for Dry Mouth Secondary to Sjogren's Syndrome

After being diagnosed with Sjogren's Syndrome, a condition which causes dry eyes and decreased saliva production, Evoxac has helped to alleviate some of my symptoms. I've heard of others experiencing side effects like dizziness or vision problems, but the benefits of this medication outweigh those for me.

1

Patient Review

5/2/2019

Cevimeline Hydrochloride for Dry Mouth Secondary to Sjogren's Syndrome

After taking just one pill, I was so dizzy and nauseous that I had to lay down and take a nap. Once I woke up, I felt better but still experienced excessive sweating. No thanks; I'll stick to gum for my dry mouth problems.

1

Patient Review

4/10/2018

Cevimeline Hydrochloride for Dry Mouth Secondary to Sjogren's Syndrome

Within three days of taking this medication, I developed really severe acid reflux which made it incredibly painful to eat anything other than soup.

1

Patient Review

11/5/2020

Cevimeline Hydrochloride for Dry Mouth Secondary to Sjogren's Syndrome

The price is way too high. I can't afford this.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cevimeline hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is cevimeline hcl used for?

"Cevimeline is used to treat the symptoms of dry mouth often experienced by patients with Sjögren's syndrome. It works by stimulating the production of saliva by the salivary glands. This medicine is available only with your doctor's prescription."

Answered by AI

Does cevimeline help dry eyes?

"30 mg of cevimeline tid was significantly more effective than placebo in improving dry eyes (P = .007)."

Answered by AI

What are side effects of cevimeline?

"Symptoms of a bladder infection include: pain in the bladder area, bloody or cloudy urine, body aches or pain, difficult, burning, or painful urination, difficulty in breathing, dryness or soreness of the throat, ear congestion, frequent urge to urinate."

Answered by AI

What type of drug is cevimeline?

"Cevimeline is a medication used to relieve the symptoms of a dry mouth, specifically in patients with Sjogren's syndrome. Sjogren's syndrome is a condition that affects the immune system, causing dryness in certain parts of the body such as the eyes and mouth. Cevimeline works by stimulating the production of saliva, which helps to keep the mouth moist and comfortable."

Answered by AI