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What is Cevimeline Hydrochloride
CevimelineThe Generic name of this drug
Treatment SummaryCevimeline is a drug used to treat dry mouth caused by Sjögren's syndrome. It works by stimulating certain receptors in the body that help increase the production of saliva. It has been approved by the FDA for use in treating this condition.
Evoxacis the brand name
Cevimeline Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Evoxac
Cevimeline
2000
14
Approved as Treatment by the FDA
Cevimeline, also known as Evoxac, is approved by the FDA for 2 uses including Xerostomia and Sjogren's Syndrome (SS) .Xerostomia
Sjogren's Syndrome (SS)
Effectiveness
How Cevimeline Hydrochloride Affects PatientsCevimeline is a drug that stimulates the muscarinic receptors in the body. When taken in the right amount, it can increase saliva and sweat production, as well as increase the strength of muscles in the digestive and urinary systems.
How Cevimeline Hydrochloride works in the bodyCevimeline is a drug that works by activating two types of muscarinic receptors in the body. The first type is found in secretory glands, and when stimulated, it increases the amount of fluids secreted. The second type is found in smooth muscle and glands, and when stimulated, it causes the muscles to contract and increases the amount of fluids secreted. This helps to relieve the symptoms of dry mouth.
When to interrupt dosage
The measure of Cevimeline Hydrochloride is contingent upon the diagnosed affliction. The amount of dosage is likewise variable, in consideration of the technique of delivery outlined in the table beneath.Condition
Dosage
Administration
Xerostomia
30.0 mg,
, Oral, Capsule, Capsule - Oral
Warnings
There are 20 known major drug interactions with Cevimeline Hydrochloride.Common Cevimeline Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Cevimeline.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Cevimeline.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Cevimeline.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Cevimeline.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Cevimeline.
Cevimeline Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Cevimeline Hydrochloride?
8 active investigations are assessing the potential of Cevimeline Hydrochloride to alleviate symptoms of Sjögren's Syndrome.Condition
Clinical Trials
Trial Phases
Xerostomia
0 Actively Recruiting
Cevimeline Hydrochloride Reviews: What are patients saying about Cevimeline Hydrochloride?
5Patient Review
10/28/2015 This treatment has been a lifesaver for me. After being diagnosed with sjogrens, I was so depressed over the dry mouth and horrible breath issues. Rhuemy prescribed Cevimeline HCL 30mg 3x/day. WOW!!!! Now I can speak with out a dry mouth and it even seems to be helping my eyes. I have been on it less than 8 mos, but I have only one side effect-sometimes I get up 2-3x at night to go urinate. The pill seems to create water all over for me. Small price to pay for a normal-feeling
5Patient Review
1/3/2013 This treatment really helped me. I'm grateful for modern medicine.
4.7Patient Review
1/9/20094.3Patient Review
4/16/2021 I followed the doctor's orders and took this medication three times a day. I'm really happy with how it's helped me, especially since it didn't cause any bothersome side effects.
4Patient Review
10/9/2021 I just realized that most of my symptoms are caused by Cevimaline. But it's great for hydrating your mouth. My eyes need more help, though. increased urination can also be a problem, so be careful about dehydration. Makes talking much easier--until you realize you're spraying saliva all over!
Patient Q&A Section about cevimeline hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is cevimeline hcl used for?
"Cevimeline is used to treat the symptoms of dry mouth often experienced by patients with Sjögren's syndrome. It works by stimulating the production of saliva by the salivary glands. This medicine is available only with your doctor's prescription."
Answered by AI
Does cevimeline help dry eyes?
"30 mg of cevimeline tid was significantly more effective than placebo in improving dry eyes (P = .007)."
Answered by AI
What are side effects of cevimeline?
"Symptoms of a bladder infection include: pain in the bladder area, bloody or cloudy urine, body aches or pain, difficult, burning, or painful urination, difficulty in breathing, dryness or soreness of the throat, ear congestion, frequent urge to urinate."
Answered by AI
What type of drug is cevimeline?
"Cevimeline is a medication used to relieve the symptoms of a dry mouth, specifically in patients with Sjogren's syndrome. Sjogren's syndrome is a condition that affects the immune system, causing dryness in certain parts of the body such as the eyes and mouth. Cevimeline works by stimulating the production of saliva, which helps to keep the mouth moist and comfortable."
Answered by AI