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What is Dasatinib
DasatinibThe Generic name of this drug
Treatment SummaryDasatinib is a pill taken to treat chronic myelogenous leukemia (CML). The drug targets and blocks certain proteins found in cancer cells, such as BCRABL, SRC, Ephrins, and GFR.
Sprycelis the brand name
Dasatinib Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sprycel
Dasatinib
2006
7
Approved as Treatment by the FDA
Dasatinib, also called Sprycel, is approved by the FDA for 12 uses like blast phase Chronic myelocytic leukemia and Accelerated phase chronic myologenic leukemia .blast phase Chronic myelocytic leukemia
Accelerated phase chronic myologenic leukemia
Myeloid Leukemia, Chronic, Chronic Phase
Chronic Myeloid Leukemia (CML)
Acute Lymphoblastic Leukemia (ALL)
Newly Diagnosed
Leukemia, Myeloid, Chronic-Phase
Leukemia, Myeloid, Accelerated Phase
Therapeutic procedure
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Chemotherapy
Acute Lymphoblastic Leukemia
Effectiveness
How Dasatinib Affects PatientsDasatinib is a drug taken by mouth that helps to stop the growth of certain cancer cells by blocking a certain type of protein found in these cells.
How Dasatinib works in the bodyDasatinib is a drug used to treat cancer. It works by blocking the activity of certain protein kinases, which are enzymes involved in cell growth and survival. Dasatinib is able to block several different types of protein kinases, including those involved in Leukemia, Chronic Myeloid Leukemia, and Acute Lymphoblastic Leukemia. It is also able to overcome resistance to other drugs caused by mutations or other factors.
When to interrupt dosage
The suggested amount of Dasatinib is contingent upon the diagnosed condition. The dosage fluctuates depending on the technique of delivery (e.g. Powder, for suspension or Oral) elucidated in the table below.Condition
Dosage
Administration
Leukemia, Myeloid, Accelerated Phase
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Acute Lymphoblastic Leukemia
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Chemotherapy
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Newly Diagnosed
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Leukemia, Myeloid, Chronic-Phase
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Therapeutic procedure
70.0 mg, , 20.0 mg, 50.0 mg, 100.0 mg, 80.0 mg, 140.0 mg, 10.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral
Warnings
There are 20 known major drug interactions with Dasatinib.Common Dasatinib Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Dasatinib is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Dasatinib is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The metabolism of Abemaciclib can be decreased when combined with Dasatinib.
Abetimus
Major
The risk or severity of adverse effects can be increased when Dasatinib is combined with Abetimus.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be decreased when combined with Dasatinib.
Dasatinib Toxicity & Overdose RiskAnimals that overdose on this drug may experience damage to their heart.
Dasatinib Novel Uses: Which Conditions Have a Clinical Trial Featuring Dasatinib?
Presently, 177 active trials are assessing the potential of Dasatinib to provide relief for Acute Lymphoblastic Leukemia.Condition
Clinical Trials
Trial Phases
Acute Lymphoblastic Leukemia
118 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Chemotherapy
4 Actively Recruiting
Phase 1, Phase 3, Not Applicable
Leukemia, Myeloid, Chronic-Phase
3 Actively Recruiting
Phase 2, Phase 1
Newly Diagnosed
3 Actively Recruiting
Phase 3, Phase 1
Leukemia, Myeloid, Accelerated Phase
0 Actively Recruiting
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Dasatinib Reviews: What are patients saying about Dasatinib?
5Patient Review
3/24/2016 Sprycel/Dasatinib can cause some tough side effects, like edema in the legs and feet. For me, this drug wasn't essential since I've already had a stem cell transplant. But if you're looking for a treatment that will keep your cancer in remission by itself, this might be the one for you.
5Patient Review
12/7/2020 I've been taking dasatinib from BonHoa Pharmacy for a while now and have generally been pleased. However, I've started experiencing some new symptoms that I believe are related to the medicine. These include bone pain, difficulty breathing, and fatigue. Even so, I wouldn't want to switch medications because this is the only one I haven't had any side effects with.
5Patient Review
10/18/20074Patient Review
6/27/2014 I've been in remission for 18 months.
3Patient Review
3/30/2011 I haven't tried it yet, but I'm interested to see how it works.
Patient Q&A Section about dasatinib
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is dasatinib an immunotherapy?
"The study found that drug dasatinib, which is used to treat leukemia, makes immunotherapy more effective against cancer."
Answered by AI
What is dasatinib used for?
"This medication is used to treat Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) in adults and children. It is also used to treat Ph+ CML and Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) in adults when other medicines (eg, imatinib) or treatments have not worked well."
Answered by AI
Is dasatinib a chemotherapy drug?
"A targeted therapy is a type of cancer treatment that targets the changes in cancer cells that help them grow, divide, and spread.
The trade name for the generic chemotherapy drug Dasatinib is SPRYCEL. In some cases, health care professionals may use the trade name SPRYCEL when referring to the generic drug name Dasatinib. SPRYCEL is a targeted therapy. A targeted therapy is a type of cancer treatment that targets the changes in cancer cells that help them grow, divide, and spread."
Answered by AI