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What is Depo-Estradiol
Estradiol cypionateThe Generic name of this drug
Treatment SummaryEstradiol Cypionate is a form of the hormone estrogen, which is naturally found in the human body. It is used to treat symptoms related to menopause, such as hot flashes, vaginal dryness, mood changes, irregular periods, chills, and sleeping problems. It is also used to treat hypoestrogenism, a condition caused by low levels of estrogen. Estradiol Cypionate is available as an intramuscular injection, known as Depo-Estradiol, and is metabolized into the hormone estradiol once absorbed. Estradiol is more potent than other
Depo-Estradiolis the brand name
Depo-Estradiol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Depo-Estradiol
Estradiol cypionate
1979
2
Approved as Treatment by the FDA
Estradiol cypionate, also called Depo-Estradiol, is approved by the FDA for 4 uses like Menopause and moderate Menopausal Vasomotor Symptoms .Menopause
moderate Menopausal Vasomotor Symptoms
Low Testosterone
Helps manage Hypogonadism
hypoestrogenism
Helps manage hypoestrogenism
Effectiveness
How Depo-Estradiol Affects PatientsEstrogen works in the body by binding to two types of receptors (ERα and ERβ) and a protein (GPER) in many places, including the breasts, uterus, ovaries, skin, prostate, bone, fat, and brain. Estrogen causes a number of different responses in the body by binding to these receptors and proteins.
How Depo-Estradiol works in the bodyWhen estradiol enters a cell, it binds to a receptor in the cell. This binding then triggers a chain reaction, leading to the formation of proteins that help express the effects of estradiol. Estrogens also help create proteins that aid in the regulation of hormones, such as sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and follicle-stimulating hormone (FSH). The end result of this process is increased estrogenic activity, which can reverse some of the symptoms of menopause and low levels of estrogen.
When to interrupt dosage
The amount of Depo-Estradiol is reliant upon the diagnosed condition, including Low Testosterone, hypoestrogenism and Menopause. The dosage can differ, based on the approach of administration specified in the table below.Condition
Dosage
Administration
Low Testosterone
, 5.0 mg/mL, 50.0 mg/mL
, Intramuscular, Injection - Intramuscular, Injection, Injection, suspension, Injection, suspension - Intramuscular
hypoestrogenism
, 5.0 mg/mL, 50.0 mg/mL
, Intramuscular, Injection - Intramuscular, Injection, Injection, suspension, Injection, suspension - Intramuscular
Menopause
, 5.0 mg/mL, 50.0 mg/mL
, Intramuscular, Injection - Intramuscular, Injection, Injection, suspension, Injection, suspension - Intramuscular
moderate Menopausal Vasomotor Symptoms
, 5.0 mg/mL, 50.0 mg/mL
, Intramuscular, Injection - Intramuscular, Injection, Injection, suspension, Injection, suspension - Intramuscular
Warnings
There are 20 known major drug interactions with Depo-Estradiol.Common Depo-Estradiol Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Estradiol cypionate.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Estradiol cypionate.
Alectinib
Major
The metabolism of Alectinib can be increased when combined with Estradiol cypionate.
Aminophylline
Major
The metabolism of Aminophylline can be increased when combined with Estradiol cypionate.
Anastrozole
Major
The therapeutic efficacy of Anastrozole can be decreased when used in combination with Estradiol cypionate.
Depo-Estradiol Novel Uses: Which Conditions Have a Clinical Trial Featuring Depo-Estradiol?
19 active studies are currently being conducted to assess the efficacy of Depo-Estradiol in alleviating hypoestrogenism, Low Testosterone and Menopausal symptoms.Condition
Clinical Trials
Trial Phases
hypoestrogenism
1 Actively Recruiting
Phase 4
Menopause
0 Actively Recruiting
moderate Menopausal Vasomotor Symptoms
0 Actively Recruiting
Low Testosterone
6 Actively Recruiting
Phase 4, Phase 2, Phase 1
Depo-Estradiol Reviews: What are patients saying about Depo-Estradiol?
5Patient Review
5/31/2011 Completely eliminated the hot flashes I was experiencing. Also had the added bonus of making my muscles more toned. I'm very pleased with this product and wish my doctor had prescribed it sooner.
5Patient Review
7/31/2009 I saw low changes on my legs and breast after using this treatment.
4.7Patient Review
6/12/2009 My doctor prescribed me this injection as a last resort to combat my perpetual state of heat. Unfortunately, it did not help and I'm still struggling after a year. If anyone has any suggestions, please let me know because I'm desperate at this point.
4Patient Review
5/10/20091.3Patient Review
3/29/2022 Depo is terrible and not at all comparable to Delestrogen. It gave me a heart attack.
Patient Q&A Section about depo-estradiol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long is Depo-Estradiol good for?
"You and your healthcare provider should talk regularly about whether you still need treatment with DEPO-ESTRADIOL."
Answered by AI
When will Depo-Estradiol be available?
"Pfizer is currently out of stock of Depo-Estradiol 5 mg/mL 5 mL vials for intramuscular injection, and estimates that they will not have any available until December of 2022."
Answered by AI
What is Depo-Estradiol made from?
"Estradiol cypionate injection is given intramuscularly. Each mL contains: 5 mg/mL—5 mg estradiol cypionate, 5.4 mg chlorobutanol anhydrous (chloral derivative) added as preservative; in 913 mg cottonseed oil."
Answered by AI
What is Depo-Estradiol used for?
"This medication may also be used by women who have had their ovaries removed.
This medication is designed to mimic the female hormone estrogen in order to help reduce menopause symptoms such as hot flashes and vaginal dryness. These symptoms are caused by a decrease in the body's production of estrogen and can also be present in women who have had their ovaries removed."
Answered by AI