AIH + NMES for Multiple Sclerosis

Palo Alto (17 mi)

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: Shirley Ryan AbilityLab

No Placebo Group

Trial Summary

What is the purpose of this trial?The purpose of this study is to examine how neuromuscular electrical stimulation (NMES), may synergistically enhance corticospinal excitability in people with relapsing form multiple sclerosis (MS). This is an important intermediate step to evaluate the potential of AIH + NMES as a plasticity-priming strategy for more efficacious interventions for persons with MS. This study will measure ankle torque generation and amplitude of motor evoked potentials (MEPs) using a repeated measures study design in order to better understand the effects of AIH combined with NMES, as compared to only receiving NMES, and only receiving AIH.

Eligibility Criteria

This trial is for individuals with relapsing multiple sclerosis. Participants should be able to perform the required physical tasks and have no other health conditions that could interfere with the study.

Inclusion Criteria

My condition is a relapsing form of multiple sclerosis.

My disability level is moderate to severe but I can still walk.

I have been free from cancer relapse for at least 1 year.

My ability to move around is moderately affected.

I am between 18 and 75 years old.

Exclusion Criteria

I do not have uncontrolled lung, heart, or musculoskeletal problems.

I am taking medication that affects my brain and could make seizures more likely.

I have a neurological condition not related to MS.

I often have severe or unexplained headaches.

My blood pressure is within the normal range.

I have a history of epilepsy or seizures.

I do not have ongoing major depression, psychosis, or cognitive issues.

I have had a stroke in the past.

I have had surgery on my head.

Treatment Details

The study is testing how well neuromuscular electrical stimulation (NMES) works when combined with acute intermittent hypoxia (AIH). It's looking at muscle strength and nerve responses in people with MS, comparing NMES alone, AIH alone, and both together.

3Treatment groups

Experimental Treatment

Group I: NMES aloneExperimental Treatment1 Intervention

Participants will undergo repetitive common peroneal nerve stimulation for up to 30 minutes.

Group II: Combined AIH and NMESExperimental Treatment2 Interventions

Participants will undergo 30 minutes of AIH. Immediately following, participants will undergo NMES for up to 30 minutes.

Group III: AIH aloneExperimental Treatment1 Intervention

Participants will undergo 30 minutes of AIH.