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Behavioural Intervention

AIH + NMES for Multiple Sclerosis

N/A

Waitlist Available

Research Sponsored by Shirley Ryan AbilityLab

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosis of relapsing form of MS

Expanded Disability Status Scale (EDSS) score of at least 3 and no more than 6.5

Must not have

Uncontrolled medical problems affecting the lungs (pulmonary diseases including chronic obstructive pulmonary disease), the heart (cardiovascular diseases) or the musculoskeletal system (orthopedic diseases)

Receiving drugs acting primarily on the central nervous system, which lower the seizure threshold such as antipsychotic drugs (chlorpromazine, clozapine) or tricyclic antidepressants

Timeline

Screening 3 weeks

Treatment Varies

Follow Up immediately prior to and within 60 minutes after the intervention.

Awards & highlights

No Placebo-Only Group

Summary

"This trial aims to see if using neuromuscular electrical stimulation can improve nerve activity in people with relapsing form multiple sclerosis. The study will compare the effects of combining AIH with NMES

Who is the study for?

This trial is for individuals with relapsing multiple sclerosis. Participants should be able to perform the required physical tasks and have no other health conditions that could interfere with the study.

What is being tested?

The study is testing how well neuromuscular electrical stimulation (NMES) works when combined with acute intermittent hypoxia (AIH). It's looking at muscle strength and nerve responses in people with MS, comparing NMES alone, AIH alone, and both together.

What are the potential side effects?

Possible side effects may include discomfort from electrical stimulation or breathing issues due to hypoxia. The exact side effects will depend on individual tolerance to these interventions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My condition is a relapsing form of multiple sclerosis.

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My disability level is moderate to severe but I can still walk.

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I have been free from cancer relapse for at least 1 year.

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My ability to move around is moderately affected.

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I am between 18 and 75 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I do not have uncontrolled lung, heart, or musculoskeletal problems.

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I am taking medication that affects my brain and could make seizures more likely.

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I have a neurological condition not related to MS.

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I often have severe or unexplained headaches.

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My blood pressure is within the normal range.

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I have a history of epilepsy or seizures.

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I do not have ongoing major depression, psychosis, or cognitive issues.

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I have had a stroke in the past.

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I have had surgery on my head.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ immediately prior to and within 60 minutes after the intervention.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~immediately prior to and within 60 minutes after the intervention.

This trial's timeline: 3 weeks for screening, Varies for treatment, and immediately prior to and within 60 minutes after the intervention. for reporting.