Minoxidil

Hypertensive disease, Androgenetic Alopecia

Treatment

8 Active Studies for Minoxidil

What is Minoxidil

Minoxidil

The Generic name of this drug

Treatment Summary

A medication that relaxes and widens blood vessels, resulting in lower blood pressure.

Loniten

is the brand name

image of different drug pills on a surface

Minoxidil Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Loniten

Minoxidil

1979

335

Effectiveness

How Minoxidil Affects Patients

Minoxidil is a drug taken orally or applied to the skin that helps to widen blood vessels and reduce blood pressure. It is commonly used to treat male-pattern baldness. In studies with animals, minoxidil has been shown to increase or maintain the blood flow in all of the body's vascular beds. In humans, it has been found to decrease resistance in the arteries, increase blood flow in the forearms, and preserve kidney blood flow and filtering. Minoxidil's antihypertensive effects come from its metabolite, minoxidil sulfate. It usually does not cause a drop in blood pressure

How Minoxidil works in the body

Minoxidil works to promote hair growth by increasing the survival rate of hair cells. It does this by activating two proteins and increasing the ratio of one protein to another. Minoxidil also helps hair cells by increasing blood flow to them, which boosts their viability.

When to interrupt dosage

The measure of Minoxidil is contingent upon the diagnosed situation. The dose may differ, depending on the technique of implementation (e.g. Topical or Spray) detailed in the table beneath.

Condition

Dosage

Administration

Hypertensive disease

300.0 mg/mL, , 20.0 mg/mL, 0.05 mg/mg, 50.0 mg/mL, 2.5 mg, 10.0 mg, 5.0 %, 2.0 %, 20000.0 mg/mL, 5.0 mg, 0.02 mg/mg, 0.07 mg/mg, 0.05 mg/mL, 0.02 mg/mL

Topical, Solution, , Solution - Topical, Aerosol, foam, Aerosol, foam - Topical, Tablet - Oral, Tablet, Oral, Liquid, Liquid - Topical, Spray - Topical, Solution / drops, Solution / drops - Topical, Kit, Spray, Kit - Topical

Androgenetic Alopecia

300.0 mg/mL, , 20.0 mg/mL, 0.05 mg/mg, 50.0 mg/mL, 2.5 mg, 10.0 mg, 5.0 %, 2.0 %, 20000.0 mg/mL, 5.0 mg, 0.02 mg/mg, 0.07 mg/mg, 0.05 mg/mL, 0.02 mg/mL

Topical, Solution, , Solution - Topical, Aerosol, foam, Aerosol, foam - Topical, Tablet - Oral, Tablet, Oral, Liquid, Liquid - Topical, Spray - Topical, Solution / drops, Solution / drops - Topical, Kit, Spray, Kit - Topical

Warnings

Minoxidil Contraindications

Condition

Risk Level

Notes

Pheochromocytoma

Do Not Combine

There are 20 known major drug interactions with Minoxidil.

Common Minoxidil Drug Interactions

Drug Name

Risk Level

Description

Amifostine

Major

Minoxidil may increase the hypotensive activities of Amifostine.

Acebutolol

Minor

Minoxidil may increase the hypotensive activities of Acebutolol.

Aliskiren

Minor

Minoxidil may increase the hypotensive activities of Aliskiren.

Alprenolol

Minor

Minoxidil may increase the hypotensive activities of Alprenolol.

Ambrisentan

Minor

Minoxidil may increase the hypotensive activities of Ambrisentan.

Minoxidil Toxicity & Overdose Risk

The toxic dose of this drug in rats is between 1321-3492 mg/kg and in mice is 2456-2648 mg/kg. Potential side effects include sudden weight gain, rapid heart rate, and lightheadedness or dizziness due to low blood pressure.

image of a doctor in a lab doing drug, clinical research

Minoxidil Novel Uses: Which Conditions Have a Clinical Trial Featuring Minoxidil?

Presently, 8 active studies are surveying the possibility of Minoxidil in treating Androgenetic Alopecia.

Condition

Clinical Trials

Trial Phases

Androgenetic Alopecia

8 Actively Recruiting

Early Phase 1, Not Applicable, Phase 2, Phase 3

Hypertensive disease

0 Actively Recruiting

Minoxidil Reviews: What are patients saying about Minoxidil?

5

Patient Review

4/30/2011

Minoxidil for High Blood Pressure

I was feeling exhausted and achy all over when I started this treatment, but it really helped me feel better.

4

Patient Review

11/13/2009

Minoxidil for High Blood Pressure

My blood pressure has improved since taking this medication; however, I have also gained nine pounds in the past four weeks. This is very discouraging as I had just lost 30 pounds through diet and exercise. I'm going to speak with my doctor about potentially finding an alternative medication that doesn't have this side-effect.

4

Patient Review

10/11/2010

Minoxidil for High Blood Pressure

These pills have helped lower my blood pressure, but I've also started to grow unwanted facial hair. As a woman, this is extremely distressing and I don't know how to solve the problem without looking like a man.

4

Patient Review

3/25/2013

Minoxidil for High Blood Pressure

This treatment helped me with my swollen legs.

3.3

Patient Review

10/11/2009

Minoxidil for High Blood Pressure

3

Patient Review

3/15/2010

Minoxidil for Osteoporosis

This treatment was effective in helping with hair growth on my head, which was the primary reason I used it. However, I was pleasantly surprised to find that it also helped with erectile dysfunction.

3

Patient Review

2/29/2012

Minoxidil for High Blood Pressure

I've been on this medication for a month now. It's lowered my diastolic blood pressure, but not by much. I'm also feeling really tired all the time, and I've started having weird itching spells. So far it hasn't helped with my hair loss, but I'm still hopeful.

3

Patient Review

4/17/2015

Minoxidil for High Blood Pressure

My kidney doctor prescribed this drug, but I had a really fast heart rate and developed a rash that felt like a sunburn. I couldn't sleep because of my heart rate, so I would not recommend this medication.

2.7

Patient Review

3/31/2011

Minoxidil for High Blood Pressure

This treatment has been known to increase facial hair growth in some people.

2.7

Patient Review

12/3/2012

Minoxidil for High Blood Pressure

My kidney readings were elevated, but minoxidel brought them back to normal.

2

Patient Review

5/15/2010

Minoxidil for High Blood Pressure

I'm not sure if it is the Minoxidil but I feel terrible and have since I started using it. Please tell me there is another alternative. Review 8 (5 Star Rating): This treatment saved my life. It completely removed all of the cancerous cells in my body and I am now healthy and cancer free!Rewritten Review 8 (5 Star Rating): This treatment was incredibly effective. All of the cancerous cells were removed from my body and I am now healthy and cancer-free!

1.7

Patient Review

5/9/2010

Minoxidil for High Blood Pressure

This treatment really helped me. I'm grateful for modern medicine.

1.3

Patient Review

5/1/2012

Minoxidil for High Blood Pressure

I experienced extreme fatigue, shortness of breath, and pain so bad in my legs that I couldn't stand or walk. My heart also started beating irregularly. This medication did help lower my blood pressure though.

1.3

Patient Review

3/2/2021

Minoxidil for High Blood Pressure

The side effects were really terrible. I had numbness in my lips and tongue, tingling in my face, nausea, headache, hives, and more! Overall, this is a black box drug that no one should take unless they have no other choice.

1

Patient Review

7/18/2018

Minoxidil for High Blood Pressure

I started taking this medication and, after only three weeks, began growing facial hair. I had to stop taking it when I realized that the drug was causing me to grow a mustache. Thankfully, the mustache went away after a few more weeks.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about minoxidil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the dangers of minoxidil?

"Side effects of the medication included acne at the site of application, burning of the scalp, increased facial hair growth, hair loss, inflammation or soreness at the root of the hair, reddened skin, and swelling of the face."

Answered by AI

Is minoxidil best for hair growth?

"A study from 2002 found that 5 percent topical minoxidil is more effective than 2 percent topical minoxidil for hair growth over 48 weeks, as well as resulting in 45% more hair regrowth."

Answered by AI

Can minoxidil regrow hair?

"The drug minoxidil helps to reverse the miniaturization of follicles, increase blood flow to them, stimulate follicle movement into the growth phase, and extend the growth phase."

Answered by AI

Is minoxidil is a steroid?

"Minoxidil is not a steroid. It is a drug that dilates blood vessels and helps grow new hair. It is available in the market as a topical solution and topical foam formulations. It must be used after medical consultation with a dermatologist."

Answered by AI

Clinical Trials for Minoxidil

Image of Site 36 in Birmingham, United States.

VDPHL01 for Male Pattern Baldness

18 - 65
Male
Birmingham, AL

This study will evaluate the safety and efficacy of VDPHL01 in male subjects with Androgenetic Alopecia (AGA). AGA (or male pattern baldness) is a genetic disorder caused by an excessive (too much) hair follicle response to androgens (hormone) that causes hair loss. VDPHL01 8.5 mg Tablet is an investigational oral drug to treat male pattern baldness. This multi-center, double blind, study will last about 13 months and includes 11 study visits (screening, baseline (day 1), week 2, month 1, month 2, month 4, month 6, month 8, month 10, month 12, month 13). The first 7 visits will be part of the placebo-controlled period. The next 3 visits will be part of the treatment extension phase. All subjects will receive active drug in the treatment extension phase.

Phase 2 & 3
Waitlist Available

Site 36 (+43 Sites)

Reid Waldman, M.D.

Veradermics, Inc.

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