Laser treatment for Wrinkles

Recruiting in Palo Alto (17 mi)

Overseen byMurad Alam, MD

Age: 18 - 65

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Phase < 1

Waitlist Available

Sponsor: Northwestern University

No Placebo Group

Trial Summary

What is the purpose of this trial?The primary objective of this study is to compare the efficacy of intense focused ultrasound and carbon dioxide-fractionated laser for treatment of periorbital wrinkles.

Eligibility Criteria

This trial is for men and women aged 35-60 with moderate wrinkles around the eyes, who have skin types I-III according to the Fitzpatrick scale. Participants must understand and consent to the study's procedures. Excluded are pregnant or breastfeeding individuals, those with certain medication histories, allergies to local anesthetics, recent facial treatments, abnormal scarring tendencies, eyelid disfigurements or significant skin diseases.

Inclusion Criteria

Subjects with Fitzpatrick skin type I-III.

Subjects who are willing, have the ability to understand and provide informed consent, and are able to communicate with the investigator.

We are looking for men and women between the ages of 35 and 60 who have wrinkles around their lower eyelids and outer corners of their eyes.

Exclusion Criteria

You are currently pregnant or breastfeeding.

Subjects who have history of isotretinoin use in the preceding year

You are allergic to lidocaine or prilocaine.

+5 more

Participant Groups

The study aims to compare two methods of reducing eye wrinkles: intense focused ultrasound and carbon dioxide-fractionated laser treatment. The effectiveness of these treatments in smoothing periorbital wrinkles will be evaluated against each other.

2Treatment groups

Experimental Treatment

Active Control

Group I: Fractional photothermolysisExperimental Treatment2 Interventions

Fractional photothermolysis (FP) for treatment of photo- damaged skin is an FDA-approved method for treating facial rhytids. Fractionated treatment with 1550-nm laser is a safe, nonsurgical method for improvement of periorbital rhytides, photodamage, and scarring

Group II: High-intensity focused ultrasoundActive Control2 Interventions

High-intensity focused ultrasound (HIFUS) is an FDA-approved method for periorbital treatment and nonablative tissue tightening. Ultrasound waves induce a vibration in the tissue, generating heat and increasing the tissue temperature within a focal area. The tissue changes depend on amount of heat and exposure duration. These findings are similar to the thermally induced changes within the skin after CO2 laser fractional ablative treatments.