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What is Proloprim
TrimethoprimThe Generic name of this drug
Treatment SummaryTrimethoprim is an antibiotic that works by blocking a bacterial enzyme called dihydrofolate reductase. By blocking this enzyme, Trimethoprim prevents the growth of bacteria in the body. It is often used in combination with another antibiotic called sulfamethoxazole, but it can also be used on its own to treat urinary tract infections. Trimethoprim is related to another drug called pyrimethamine, which is used to treat parasitic infections.
Septra DSis the brand name
Proloprim Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Septra DS
Trimethoprim
1973
343
Approved as Treatment by the FDA
Trimethoprim, also called Septra DS, is approved by the FDA for 15 uses including Genus Pneumocystis and susceptible Enteritis infectious caused by Shigella flexneri .Genus Pneumocystis
Used to treat risk of Pneumocystis jiroveci pneumonia (PCP) in combination with Sulfamethoxazole
susceptible Enteritis infectious caused by Shigella flexneri
Used to treat susceptible Enteritis infectious caused by Shigella flexneri in combination with Sulfamethoxazole
Shigellosis
Used to treat Dysentery, Bacillary in combination with Sulfamethoxazole
Nocardiosis
Used to treat Nocardiosis in combination with Sulfamethoxazole
Otitis Media
Used to treat Acute Otitis Media caused by susceptible bacteria in combination with Sulfamethoxazole
Brucellosis
Used to treat Brucellosis in combination with Rifampicin
Electrolyte replacement
Used to treat Electrolyte replacement in combination with Sulfamethoxazole
Fluid replacement therapy
Used to treat Fluid replacement therapy in combination with Sulfamethoxazole
susceptible Enteritis infectious caused by Shigella sonnei
Used to treat susceptible Enteritis infectious caused by Shigella sonnei in combination with Sulfamethoxazole
Urinary tract infection
Used to treat Urinary Tract Infection caused by susceptible bacteria in combination with Sulfamethoxazole
Pneumonia, Pneumocystis
Used to treat Pneumocystis Jirovecii Pneumonia in combination with Sulfamethoxazole
Bronchitis
Used to treat Acute Exacerbation of Chronic Bronchitis (AECB) caused by susceptible bacteria in combination with Sulfamethoxazole
Diarrhea
Used to treat susceptible Travelers' Diarrhea caused by Enterotoxigenic E. Coli (ETEC) Infection in combination with Sulfamethoxazole
Cholera
Used to treat susceptible Cholera in combination with Sulfamethoxazole
Immunocompromised
Used to treat Immunocompromised in combination with Sulfamethoxazole
Effectiveness
How Proloprim Affects PatientsTrimethoprim works by disrupting the process bacteria use to make proteins and make their DNA. It is effective against several types of bacteria, but can develop resistance. In rare cases, it can cause blood disorders like low platelet or white blood cell counts, as well as sore throat, fever, pale skin, and purple spots on the skin. It's important to check with your local area to see what kinds of bacteria this drug is effective against.
How Proloprim works in the bodyTrimethoprim stops bacteria from making a chemical, tetrahydrofolic acid, that they need to survive. It works by blocking an enzyme in the bacteria that helps create this chemical. When given with another drug, sulfamethoxazole, it can stop two steps in the production of the chemical, which can be enough to kill the bacteria. On its own, trimethoprim just slows the bacteria's growth, but together with sulfamethoxazole, it can be a powerful weapon against bacterial infections.
When to interrupt dosage
The proposed measure of Proloprim is contingent upon the diagnosed condition, including Urinary tract infection, Immunocompromised and Pneumocystis Jirovecii Pneumonia. The quantity of dosage is contingent upon the technique of dispensation (e.g. Tablet - Oral or Tablet) noted in the table beneath.Condition
Dosage
Administration
Brucellosis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Diarrhea
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
bacterial blepharitis caused by susceptible bacteria
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Blepharoconjunctivitis caused by susceptible bacteria
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Nocardiosis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Immunocompromised
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Pneumonia, Pneumocystis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Urinary tract infection
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Urinary tract infection
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Shigellosis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Electrolyte replacement
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Fluid replacement therapy
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Genus Pneumocystis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Bacterial conjunctivitis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Bronchitis
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
susceptible Enteritis infectious caused by Shigella flexneri
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
susceptible Enteritis infectious caused by Shigella sonnei
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Otitis Media
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Cholera
, 1.0 mg/mL, 160.0 mg, 80.0 mg, 40.0 mg/mL, 50.0 mg/mL, 100.0 mg, 0.16 mg, 1.6 mg, 20.0 mg, 200.0 mg, 90.0 mg, 16.0 mg/mL, 300.0 mg, 40.0 mg, 8.0 mg/mL, 9.0 mg/mL
, Ophthalmic, Solution / drops - Ophthalmic, Oral, Tablet, Tablet - Oral, Suspension, Suspension - Oral, Solution, Solution - Oral, Solution - Ophthalmic, Intravenous, Liquid, Liquid - Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Solution - Intravenous, Injection, Injection - Intravenous, Solution / drops, Liquid - Ophthalmic
Warnings
Proloprim has eight recognized contraindications and should not be combined with the conditions given in the below table.Proloprim ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Trimethoprim may interact with Pulse Frequency
Purpura, Thrombocytopenic, Idiopathic
Do Not Combine
hepatic damage
Do Not Combine
Megaloblastic anemia caused by Folate deficiency
Do Not Combine
unable to monitor renal function
Do Not Combine
Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Trimethoprim may interact with Pulse Frequency
Common Proloprim Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Trimethoprim.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Trimethoprim.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Trimethoprim.
Cisplatin
Major
The serum concentration of Cisplatin can be increased when it is combined with Trimethoprim.
Clofarabine
Major
The serum concentration of Clofarabine can be increased when it is combined with Trimethoprim.
Proloprim Toxicity & Overdose RiskThe lowest toxic dose of trimethoprim in mice and rats is 2764 mg/kg and greater than 5300 mg/kg respectively. Taking more than 1 gram of trimethoprim may lead to signs of overdose such as nausea, vomiting, dizziness, headaches, confusion, and reduced bone marrow activity. Treatment should involve supportive care and possibly stomach pumping. Acidifying the urine may help to remove the drug from the body. Hemodialysis may be somewhat effective, but peritoneal dialysis will not help.
Proloprim Novel Uses: Which Conditions Have a Clinical Trial Featuring Proloprim?
8 active clinical trials are currently being conducted to explore the potential of Proloprim to treat susceptible Enteritis infectious caused by Shigella flexneri, Blepharoconjunctivitis caused by susceptible bacteria and Diarrhea.Condition
Clinical Trials
Trial Phases
Bacterial conjunctivitis
0 Actively Recruiting
Bronchitis
0 Actively Recruiting
Nocardiosis
0 Actively Recruiting
Urinary tract infection
0 Actively Recruiting
Shigellosis
0 Actively Recruiting
Brucellosis
0 Actively Recruiting
bacterial blepharitis caused by susceptible bacteria
0 Actively Recruiting
Immunocompromised
4 Actively Recruiting
Not Applicable, Phase 1, Phase 3
Otitis Media
0 Actively Recruiting
Genus Pneumocystis
0 Actively Recruiting
Blepharoconjunctivitis caused by susceptible bacteria
0 Actively Recruiting
Fluid replacement therapy
0 Actively Recruiting
Cholera
2 Actively Recruiting
Phase 4, Phase 1
Urinary tract infection
0 Actively Recruiting
susceptible Enteritis infectious caused by Shigella sonnei
0 Actively Recruiting
Pneumonia, Pneumocystis
1 Actively Recruiting
Phase 3
susceptible Enteritis infectious caused by Shigella flexneri
0 Actively Recruiting
Electrolyte replacement
0 Actively Recruiting
Diarrhea
0 Actively Recruiting
Proloprim Reviews: What are patients saying about Proloprim?
4.7Patient Review
3/17/20112.3Patient Review
8/3/2013 Unfortunately, this medication made me feel almost as bad as the bladder infection itself. I will be requesting a different option from my doctor if I ever experience cystitis again.
2.3Patient Review
6/27/2014 This medication raised my potassium levels to a dangerously high level.
Patient Q&A Section about proloprim
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of taking trimethoprim?
"These may be symptoms of a serious condition called sepsis."
Answered by AI
What is DermacinRx used for?
"Diclofenac is an anti-inflammatory drug that is not a steroid. It is a combination medicine that is used to treat joint pain, stiffness, and swelling caused by osteoarthritis of the knees."
Answered by AI
What is Proloprim used for?
"It Jun 3, 2022 is used to treat bacterial infections."
Answered by AI
What is the mechanism of action of trimethoprim?
"Trimethoprim prevents the reduction of dihydrofolate to tetrahydrofolate, which is the active form of folic acid. It is effective against most gram-positive aerobic cocci and some gram-negative aerobic bacilli."
Answered by AI