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Propellant

Inhaler Propellants for Asthma

Phase 1
Waitlist Available
Research Sponsored by GlaxoSmithKline
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Confirmed diagnosis of asthma for at least 6 months
Receiving specific asthma treatments at a stable dose for at least 12 weeks prior to screening
Must not have
History of life-threatening or unstable asthma
Use of specific biologic/immunosuppressive therapies
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to compare two different propellants, HFA-152a and HFA-134a, to see if they cause airways to tighten when used in inhalers. The goal

Who is the study for?
This trial is for adults aged 18-45 with mild asthma, diagnosed at least 6 months ago. They must have stable asthma without severe flare-ups in the past 6 months and not be on certain medications or therapies. Women of childbearing age should meet pregnancy prevention criteria.
What is being tested?
The study compares two propellants used in inhalers: HFA-152a (test) and HFA-134a (reference). It aims to see if they cause airway tightening when used by people with mild asthma, looking for a greener option with less impact on global warming.
What are the potential side effects?
Potential side effects may include reactions that cause airways to tighten, which could lead to breathing difficulties. The exact side effects will be monitored as this is part of what the study is assessing.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been diagnosed with asthma for at least 6 months.
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I have been on a stable dose of my asthma medication for at least 12 weeks.
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I haven't had a severe asthma attack in the last 6 months and no more than one in the past year.
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I am between 18 and 45 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have had severe or uncontrolled asthma.
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I am currently using or have used specific immune system therapies.
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I am on medication for my asthma.
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I have a lung condition that is not asthma.
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I have had a severe asthma attack recently.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: HFA-152A propellant followed by HFA-134A propellantExperimental Treatment2 Interventions
Group II: HFA-134A propellant followed by HFA-152A propellantExperimental Treatment2 Interventions

Find a Location

Who is running the clinical trial?

GlaxoSmithKlineLead Sponsor
4,812 Previous Clinical Trials
8,382,181 Total Patients Enrolled
302 Trials studying Asthma
500,479 Patients Enrolled for Asthma
~11 spots leftby Feb 2025
Unbiased ResultsWe believe in providing patients with all the options.
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