Nicotinamide Riboside for Acetaminophen Toxicity
Trial Summary
What is the purpose of this trial?
Over-the-counter drugs like acetaminophen (e.g., Tylenol®) can be detrimental. In space, astronauts who have pain and constant discomfort use acetaminophen extensively. Investigators are studying the effects of acetaminophen under space-like conditions since acetaminophen might affect astronauts' health. Investigators also wish to see whether a dietary supplement can reduce some negative effects of acetaminophen. It is believed that acetaminophen promotes the productions of chemicals in the body that could be toxic. In this study, measurements of these chemicals in urine after ingestion of 1 tablet of acetaminophen and compare these measurements to when acetaminophen is taken at the same time as a dietary supplement. This study will also explore whether these products are more abundant when blood is placed under conditions that mimic space. Therefore, this study will collect blood from a few volunteers who took acetaminophen, and acetaminophen with the dietary supplement.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, it focuses on the effects of acetaminophen, so you may need to continue taking it as part of the study.
What data supports the effectiveness of the drug Nicotinamide Riboside for acetaminophen toxicity?
Is Nicotinamide Riboside safe for human use?
Nicotinamide Riboside (NR), a form of vitamin B3, has been studied for safety and is generally recognized as safe for use in foods and supplements. Clinical trials in humans have shown no significant adverse effects, and studies in animals have determined safe dosage levels, although high doses may affect the liver, kidneys, ovaries, and testes.12567
How does nicotinamide riboside differ from other treatments for acetaminophen toxicity?
Nicotinamide riboside is unique because it is a form of vitamin B3 that boosts NAD+ levels in the body, which is not a typical approach for treating acetaminophen toxicity. This treatment is novel as it leverages the body's metabolic pathways to potentially counteract toxicity, unlike standard treatments that focus on directly neutralizing the toxic effects of acetaminophen.12568
Eligibility Criteria
This trial is for people who use acetaminophen (like Tylenol) to manage pain and discomfort. It's especially relevant for those in conditions similar to space travel, where such drug use is common. Participants must not be allergic to acetaminophen or the dietary supplement nicotinamide riboside.Exclusion Criteria
Trial Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive acetaminophen and acetaminophen with nicotinamide riboside to study their effects under space-like conditions
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Nicotinamide Riboside (Other)