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Radioactive Iodine

Radioactive Iodine Dosimetry for Thyroid Cancer

Phase 1
Waitlist Available
Led By Ravinder Grewal, MD
Research Sponsored by Memorial Sloan Kettering Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Adult thyroid carcinoma patients who have had a total thyroidectomy, histology confirmed by an MSKCC attending pathologist, and radioiodine remnant ablation.
Be older than 18 years old
Must not have
Thyroid cancer patients who have not demonstrated that their metastases concentrate radioiodine.
Thyroid cancer patients who do not have metastases.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing a slightly different form of radioactive iodine to see if it can more accurately predict which patients will not respond to the standard treatment.

Who is the study for?
This trial is for adults with thyroid cancer who've had their thyroid removed and previous treatment to eliminate remaining thyroid tissue. They must have metastases that absorb radioiodine, measurable disease documented in the last six months, and be planning further radioiodine therapy if needed. It's not for those under 18, pregnant, treated with radioiodine in the past nine months, or without metastases.
What is being tested?
The study tests a radioactive iodine form called 124-I to predict radiation doses received by each cancer spread (metastatic lesion) using PET scans. This could help decide if patients will benefit from another type of radioactive iodine treatment (131-I), avoiding unnecessary exposure for non-responders.
What are the potential side effects?
Radioactive iodine treatments like 124-I and 131-I can cause side effects such as dry mouth, neck pain due to thyroid inflammation, altered taste sensation, nausea or vomiting. Long-term risks may include increased chance of other cancers or fertility issues.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I had my thyroid removed due to cancer and underwent treatment to destroy leftover thyroid tissue.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
My thyroid cancer has spread and does not respond to radioiodine treatment.
Select...
My thyroid cancer has not spread to other parts of my body.
Select...
My thyroid cancer is either anaplastic or medullary.
Select...
I am under 18 years old.
Select...
I have not received a high dose of radioiodine in the last 9 months.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: 1Experimental Treatment1 Intervention
131 I-iodine (131-I), 124 I-iodine (124-I)

Find a Location

Who is running the clinical trial?

Memorial Sloan Kettering Cancer CenterLead Sponsor
1,969 Previous Clinical Trials
597,231 Total Patients Enrolled
Gustave Roussy, Cancer Campus, Grand ParisOTHER
262 Previous Clinical Trials
265,369 Total Patients Enrolled
Ravinder Grewal, MDPrincipal InvestigatorMemorial Sloan Kettering Cancer Center
4 Previous Clinical Trials
75 Total Patients Enrolled

Media Library

131 I-iodine (131-I) (Radioactive Iodine) Clinical Trial Eligibility Overview. Trial Name: NCT00673010 — Phase 1
Thyroid Cancer Research Study Groups: 1
Thyroid Cancer Clinical Trial 2023: 131 I-iodine (131-I) Highlights & Side Effects. Trial Name: NCT00673010 — Phase 1
131 I-iodine (131-I) (Radioactive Iodine) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00673010 — Phase 1
~0 spots leftby Mar 2025
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