~13 spots leftby Apr 2026

Resveratrol for Exercise Performance and Recovery

Recruiting in Palo Alto (17 mi)
Age: 18 - 65
Sex: Male
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: University of Central Florida
Must not be taking: Performance-enhancing drugs, NSAIDs
Disqualifiers: Musculoskeletal injury, Chronic pain, others
Approved in 3 Jurisdictions

Trial Summary

What is the purpose of this trial?

To examine the effects of once daily supplementation with 500mg VeriSperse® resveratrol (VRES) for 17 days on muscle function, delayed onset muscle soreness, systemic concentrations of muscular damage markers and markers of oxidative stress in resistance trained young adult males following a damaging isoinertial squat protocol (ISP).

Will I have to stop taking my current medications?

The trial requires participants to stop taking any performance-enhancing drugs and nutritional supplements known to improve physical performance for at least 28 days before starting the study. Regular use of prescription or over-the-counter medications that affect performance is also not allowed.

What data supports the effectiveness of the drug Resveratrol for exercise performance and recovery?

Research shows that trans-resveratrol, a component of Resveratrol, has anti-inflammatory and antioxidant properties, which may help in reducing inflammation and oxidative stress, potentially aiding in exercise recovery.12345

Is resveratrol generally safe for humans?

Resveratrol, found in red wine and other foods, has been studied for its potential health benefits, including anti-inflammatory and antioxidant effects. While specific safety data for humans is limited, it is generally considered safe in moderate amounts, as it is naturally present in foods like grapes and peanuts.12367

How does the drug resveratrol differ from other treatments for exercise performance and recovery?

Resveratrol is unique because it is a natural compound found in red wine that may improve exercise endurance and muscle metabolism by activating sirtuins, which are proteins involved in cellular health. Unlike other treatments, it also has antioxidant and anti-inflammatory properties, potentially offering additional health benefits.128910

Research Team

Eligibility Criteria

This trial is for young adult males who regularly engage in resistance training. They must be healthy and willing to take a daily supplement or placebo for 17 days, then perform specific squat exercises.

Inclusion Criteria

Recreationally active according to ACSM standards of at least 150 minutes exercise per week
Healthy and ready for physical activity as determined by the PAR-Q+ and MHQ
I am a man aged between 18 and 40.
See 7 more

Exclusion Criteria

Individual does not provide consent to participate in the study
Not currently participating in at least 150 minutes of physical activity per week
I am unable to perform physical exercises.
See 13 more

Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

1 week
1 visit (in-person)

Treatment

Participants receive once daily supplementation with 500mg VeriSperse® resveratrol or placebo for 17 days

2.5 weeks
13 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Resveratrol (Other)
Trial OverviewThe study tests if taking 500 mg of VeriSperse® resveratrol (VRES) daily improves muscle function, reduces soreness, and affects markers of muscle damage and oxidative stress after intense leg workouts compared to a placebo.
Participant Groups
2Treatment groups
Active Control
Placebo Group
Group I: Resveratrol SupplementationActive Control1 Intervention
Once daily (immediately upon waking) supplementation with 500mg (2 capsules) VeriSperse® resveratrol (VRES) for 17 days
Group II: PlaceboPlacebo Group1 Intervention
Once daily (immediately upon waking) supplementation with 500mg (2 capsules) Placebo (maltodextrin) for 17 days

Resveratrol is already approved in Canada for the following indications:

🇨🇦
Approved in Canada as Resveratrol for:
  • Dietary supplement for cardiovascular health and antioxidant properties

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Central Florida

Lead Sponsor

Trials
101
Recruited
1,191,000+

Dr. Michael Pape

University of Central Florida

Chief Executive Officer since 2015

PhD in Biochemistry from Purdue University, MBA from the University of Chicago Booth School of Business

Dr. James J. Hickman

University of Central Florida

Chief Medical Officer since 2020

MD from University of Central Florida College of Medicine

Gencor Pacific Group

Industry Sponsor

Trials
4
Recruited
300+

Findings from Research

Trans-resveratrol (t-RESV), found in grape skins and red wine, shows significant anti-inflammatory and anticarcinogenic properties in various experimental models, highlighting its potential as a therapeutic agent.
The cis isomer of resveratrol (c-RESV) is less studied and not commercially available, leading to a gap in understanding its pharmacological effects compared to the well-researched t-RESV.
Comparative studies of the antioxidant effects of cis- and trans-resveratrol.Orallo, F.[2022]
A new method was developed to accurately measure resveratrol levels in animal and human samples, showing high specificity and recovery rates (96.8%) with a low detection limit of 50 ng/ml.
The study demonstrated that resveratrol can be effectively incorporated into blood cells and lipoproteins, suggesting its potential role in inhibiting lipoprotein oxidation and platelet activity.
Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations.Blache, D., Rustan, I., Durand, P., et al.[2019]
Cis-resveratrol significantly reduces collagen-induced platelet aggregation in vitro, with a decrease of 43.5% at a concentration of 1 x 10(-5) M, indicating its potential as an anti-aggregating agent.
Trans-resveratrol also shows anti-aggregating effects but is slightly less effective than cis-resveratrol, suggesting that both isomers should be considered when evaluating resveratrol's overall activity in biological systems.
Antiplatelet activity of cis-resveratrol.Bertelli, AA., Giovannini, L., Bernini, W., et al.[2018]

References

1.United Arab Emiratespubmed.ncbi.nlm.nih.gov
Comparative studies of the antioxidant effects of cis- and trans-resveratrol. [2022]
Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations. [2019]
Antiplatelet activity of cis-resveratrol. [2018]
Bioavailability of trans-resveratrol from red wine in humans. [2018]
Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. [2021]
Human, rat, and mouse metabolism of resveratrol. [2019]
Anti-tumor properties of cis-resveratrol methylated analogs in metastatic mouse melanoma cells. [2018]
Effect of Resveratrol on Walking Performance in Older People With Peripheral Artery Disease: The RESTORE Randomized Clinical Trial. [2019]
Determination of trans- and cis-resveratrol in Serbian commercial wines. [2019]
Contents of resveratrol, piceid, and their isomers in commercially available wines made from grapes cultivated in Japan. [2019]