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Procedure

Laser Peripheral Iridotomy for Glaucoma

N/A
Recruiting
Led By Catherine Birt, MD, FRCSC
Research Sponsored by Sunnybrook Health Sciences Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
clinical evidence of bilateral occludable angles (PACS) defined as: Peripheral anterior synechia (PAS) absent and trabecular meshwork not visible in ≥6 clock hours under non-indentation gonioscopy, Along with, absence of PAC or PACG, in both eyes.
Be older than 18 years old
Must not have
or any sign of Angle Closure Glaucoma (manifest glaucomatous neuropathy detected by OCT).
a history suggestive of an acute angle closure attack (based on symptoms) documented intraocular pressure over 30 mmHg,
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 months from baseline visit
Awards & highlights
No Placebo-Only Group

Summary

This trial will compare the side effects and pain levels of those who have a clear indication for bilateral laser peripheral iridotomy (LPI) in the right or left eye.

Who is the study for?
This trial is for people with a condition where the eye's drainage angle is too narrow, risking glaucoma. They must have normal macular and optic nerve scans and no history of severe eye pressure or past surgeries. Both eyes should be at risk but not yet have full-blown glaucoma.
What is being tested?
The study tests if there's a difference in visual disturbances or pain when making a small hole (LPI) with a laser in different parts of the iris to prevent glaucoma. Patients are randomly chosen to get LPI either above or on the side of their iris.
What are the potential side effects?
Possible side effects include discomfort during the procedure, light flashes, blurry vision right after treatment, minor bleeding inside the eye, and increased eye pressure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
My eye exam shows I have narrow angles in both eyes but no glaucoma.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have been diagnosed with or show signs of Angle Closure Glaucoma.
Select...
I have had symptoms or an attack of very high eye pressure.
Select...
I have not had any eye surgeries.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 months from baseline visit
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months from baseline visit for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Dysphotopsias noted from baseline visit before procedure till 3 months after procedure
Secondary study objectives
Pain during the baseline visit procedure and recollection of pain till 3 months after procedure

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: Superior LPI placementActive Control1 Intervention
Each participant will be randomized to receive an LPI placement superiorly in one eye.
Group II: Temporal LPI placementActive Control1 Intervention
Each participant will be randomized to receive an LPI placement temporally in one eye.

Find a Location

Who is running the clinical trial?

Sunnybrook Health Sciences CentreLead Sponsor
681 Previous Clinical Trials
1,565,558 Total Patients Enrolled
Catherine Birt, MD, FRCSCPrincipal InvestigatorSunnybrook
1 Previous Clinical Trials
59 Total Patients Enrolled

Media Library

Yag Laser peripheral Iridotomy (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT04741919 — N/A
Angle-Closure Glaucoma Research Study Groups: Superior LPI placement, Temporal LPI placement
Angle-Closure Glaucoma Clinical Trial 2023: Yag Laser peripheral Iridotomy Highlights & Side Effects. Trial Name: NCT04741919 — N/A
Yag Laser peripheral Iridotomy (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04741919 — N/A
~40 spots leftby Dec 2025
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