What side effects are associated with this type of intervention?

Common treatments for aging, particularly those targeting muscle tissue and protein alterations, include hormone therapies and physical interventions. Hormone therapies, such as estrogen treatment, can have side effects including increased risk of cardiovascular disease, breast cancer, and thromboembolic events. Physical interventions like external pneumatic compression may cause mild local reactions such as erythema, pain, or bruising. Long-term use of treatments like botulinum toxin (BoNT) for muscle spasticity can lead to a gradual deterioration in range of motion and may not prevent the need for orthopedic surgery.

What prior FDA approvals exist?

There are no specific FDA-approved treatments directly targeting protein alterations in muscle tissue due to aging. However, treatments such as hormone replacement therapy (e.g., testosterone for men) and certain medications like sarcopenia-targeted drugs are being explored to improve muscle mass and function in older adults. Additionally, interventions like physical exercise and nutritional supplements are commonly recommended to mitigate muscle decline associated with aging.

What other types of research exist?

Promising alternatives to muscle tissue analysis for aging patients include: 1) Proteomics and glycomics using mass spectroscopy to assess patterns of proteins or glycoproteins in serum samples, which can serve as surrogate markers for muscle health. 2) Non-invasive imaging techniques such as MRI and ultrasound to evaluate muscle composition and function. 3) Biomarker panels that include cytokines, chemokines, and extracellular matrix components to monitor muscle degradation and regeneration. These methods offer less invasive, yet effective, ways to study muscle alterations in aging patients.

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Exercise Impact on Muscle Health in Aging

N/A

Recruiting

Led By Damien M Callahan, Ph.D.

Research Sponsored by University of Oregon

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adults between the ages 18-35 or 65-80 years

Be older than 18 years old

Must not have

Volunteer has known untreated endocrine disease (hypo/hyper thyroidism, Addison's Disease or Cushing's syndrome, etc.)

Unexpected weight loss >5kg is last 12 months

Timeline

Screening 3 weeks

Treatment Varies

Follow Up one week after the participant undergoes the biopsies.

Awards & highlights

No Placebo-Only Group

Summary

This trial is studying how certain proteins in muscles change with age, which might cause muscles to weaken and shrink. The goal is to help older adults who have trouble moving around by finding new ways to keep their muscles strong.

Who is the study for?

This trial is for healthy adults who feel they are aging well, aged 18-35 or 65-80, willing to undergo muscle biopsies and exercise tests. They must speak English fluently. It's not suitable for those with severe joint issues, mental health risks like dementia, untreated endocrine diseases, allergies to lidocaine, serious uncontrolled hypertension, blood clotting disorders, major organ disease, diabetes, recent steroid use or cancer treatments (except certain skin cancers), significant weight loss recently, smoking within a year or current substance abuse.

What is being tested?

The study focuses on how proteins in skeletal muscles change due to fatiguing exercises in the context of aging. The goal is to understand the link between these protein changes and muscle atrophy that comes with getting older.

What are the potential side effects?

Since this trial involves exercise and muscle biopsies as interventions rather than drugs or medical procedures there may be some discomfort from the biopsy procedure such as pain at the site of incision and bruising.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am either 18-35 or 65-80 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have an untreated hormone-related condition.

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I have lost more than 5kg unexpectedly in the last year.

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I have been treated for cancer, excluding successful Mohs Surgery for skin cancer.

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I have a serious heart, liver, kidney, or lung condition.

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I have diabetes, whether I need insulin or not.

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I have severe knee problems or have had a joint replacement.

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I have a known blood clotting disorder.

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My blood pressure is high and not well-managed (>140/90 mmHg).

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ one week after the participant undergoes the biopsies.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~one week after the participant undergoes the biopsies.

This trial's timeline: 3 weeks for screening, Varies for treatment, and one week after the participant undergoes the biopsies. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Phosphorylation of myosin binding protein c (MyBP-C)

Secondary study objectives

Muscle fiber Force

Muscle fiber Power

Muscle fiber Tension

+1 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: FatigueExperimental Treatment1 Intervention

Volunteers will perform one-legged knee extension exercise until fatigue while seated on an ergometer. Volunteers will then undergo bilateral skeletal muscle biopsies of the vastus lateralis muscle in their thigh.

0 / 9Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for aging, particularly those targeting muscle tissue, often focus on addressing protein alterations that contribute to reduced muscle size and function. These treatments may include resistance exercise, which stimulates muscle protein synthesis and improves muscle mass and strength. Additionally, dietary interventions such as increased protein intake can support muscle repair and growth. Pharmacological approaches, like the use of anabolic agents or hormone replacement therapy, aim to enhance muscle protein synthesis and counteract muscle wasting. Understanding these mechanisms is crucial for aging patients as they help maintain muscle function, reduce the risk of frailty, and improve overall quality of life.

Selecting Potential Pharmacological Interventions in Sarcopenia.