Exercise Timing for Type 2 Diabetes
Recruiting in Palo Alto (17 mi)
+2 other locations
Overseen bySteven K Malin, PhD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Recruiting
Sponsor: Rutgers, The State University of New Jersey
No Placebo Group
Trial Summary
What is the purpose of this trial?The overall purpose of the study is to test the effect of Noom on exercise and diet advice in adults with type 2 diabetes. The overarching hypothesis is that the use of Noom may promote better dietary adherence during an exercise program, thereby promoting greater weight loss and cardiometabolic health compared to lifestyle advice only. In particular, the investigators anticipate that changes in metabolic and vascular insulin sensitivity will correlate with glycemic control and blood pressure changes.
Do I have to stop taking my current medications for the trial?
The trial does not specify if you need to stop taking your current medications. However, if you are taking active weight suppression medication, you cannot participate in the trial.
What data supports the idea that Exercise Timing for Type 2 Diabetes is an effective treatment?
The available research shows that exercising at specific times can help manage blood sugar levels in people with Type 2 Diabetes. For example, one study found that moderate exercise after dinner can improve blood sugar control. Another study suggests that timing exercise to target high blood sugar levels after meals might help improve overall heart and blood sugar health. These findings indicate that when you exercise can be just as important as how much you exercise for managing Type 2 Diabetes.
12345What safety data exists for exercise timing in type 2 diabetes treatment?
The provided research does not directly address safety data for exercise timing in type 2 diabetes treatment. However, it suggests that exercise, whether in the morning or afternoon, can have beneficial effects on metabolic health, insulin sensitivity, and glycemic control. No specific safety concerns are mentioned, indicating that exercise timing is generally safe for individuals with type 2 diabetes, but the optimal timing for maximum benefit may vary.
26789Is the treatment 'Exercise Afternoon, Exercise and nutrition, Exercise Morning, Noom mobile application' promising for type 2 diabetes?
Yes, exercising in the afternoon seems to be a promising treatment for type 2 diabetes. It can improve insulin sensitivity, lower blood sugar levels, and reduce body fat more effectively than morning exercise. Combining exercise with nutrition advice or using tools like the Noom app can further support these benefits.
2671011Eligibility Criteria
Adults aged 30-70 with type 2 diabetes, a BMI between 28 and 45, not currently on weight loss meds or insulin therapy. Mustn't have significant heart, liver, kidney diseases or cancer. Non-smokers only (or those who quit over a year ago), not pregnant/nursing, and haven't been exercising regularly.Inclusion Criteria
I am currently on medication that affects my heart rate or rhythm.
I am between 30 and 70 years old.
I have been diagnosed with type 2 diabetes.
+1 more
Exclusion Criteria
I have type 1 diabetes and need insulin.
You are allergic to perflutren, which is in the study drug Definity.
My BMI is either above 46 or below 27.
+10 more
Participant Groups
The trial is testing the effectiveness of Noom for improving diet adherence during exercise in the morning vs. afternoon for better weight loss and heart health in type 2 diabetics. It's checking if this leads to better blood sugar control and blood pressure.
2Treatment groups
Experimental Treatment
Active Control
Group I: Exercise MorningExperimental Treatment2 Interventions
If subjects are randomly assigned to this group, they will participate in exercise training in the morning at a moderate to hard intensity. Subjects will be asked to regularly engage in morning exercise while supervised for about 2 weeks.
Group II: Exercise AfternoonActive Control1 Intervention
If subjects are assigned to this group, they will participate in the same exercise program but after in the afternoon.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Robert Wood Johnson University Hospital Clinical Research CenterNew Brunswick, NJ
Rutgers University Loree GymnasiumNew Brunswick, NJ
New Jersey Institute for Food, Nutrition, and HealthNew Brunswick, NJ
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Who Is Running the Clinical Trial?
Rutgers, The State University of New JerseyLead Sponsor
Noom Inc.Industry Sponsor
References
[Effect of moderate exercise for 30 min at 30 min versus 60 min after dinner on glycemic control in patients with type 2 diabetes: a randomized, crossover, self-controlled study]. [2022]To compare the effectiveness of moderate exercise for 30 min at 30 min and 60 min after dinner on glycemic control in patients with type 2 diabetes.
Acute Effect of Morning and Afternoon Aerobic Exercise on Appetite of Overweight Women. [2020]The best time of exercise along the day for weight management in overweight and obese patients is not determined. The time of exercise may influence its effect on appetite and food intake.
Personalising activity to target peak hyperglycaemia and improve cardiometabolic health in people with type 2 diabetes: protocol for a randomised controlled trial. [2022]The benefits of physical activity for glycaemic control in type 2 diabetes (T2D) are well-known. However, whether established glycaemic and cardiovascular benefits can be maximised by exercising at a certain time of day is unknown. Given postprandial glucose peaks contribute to worsening glycated haemoglobin (HbA1c) and cardiovascular risk factors, and that exercise immediately lowers blood glucose, prescribing exercise at a specific time of day to attenuate peak hyperglycaemia may improve glycaemic control and reduce the burden of cardiovascular disease in people with T2D.
A randomized, controlled trial to study the effect of exercise consultation on the promotion of physical activity in people with Type 2 diabetes: a pilot study. [2022]To evaluate the effect of exercise consultation on promotion of physical activity in people with Type 2 diabetes.
Impact of post-meal and one-time daily exercise in patient with type 2 diabetes mellitus: a randomized crossover study. [2020]To evaluate the effectiveness of short-timed post-meal and one-time daily exercise on glycemic control in patients with T2DM.
Exercise training elicits superior metabolic effects when performed in the afternoon compared to morning in metabolically compromised humans. [2021]The circadian clock and metabolism are tightly intertwined. Hence, the specific timing of interventions that target metabolic changes may affect their efficacy. Here we retrospectively compared the metabolic health effects of morning versus afternoon exercise training in metabolically compromised subjects enrolled in a 12-week exercise training program. Thirty-two adult males (58 ± 7 yrs) at risk for or diagnosed with type 2 diabetes performed 12 weeks of supervised exercise training either in the morning (8.00-10.00 a.m., N = 12) or in the afternoon (3.00-6.00 p.m., N = 20). Compared to participants who trained in the morning, participants who trained in the afternoon experienced superior beneficial effects of exercise training on peripheral insulin sensitivity (+5.2 ± 6.4 vs. -0.5 ± 5.4 μmol/min/kgFFM, p = .03), insulin-mediated suppression of adipose tissue lipolysis (-4.5 ± 13.7% vs. +5.9 ± 11%, p = .04), fasting plasma glucose levels (-0.3 ± 1.0 vs. +0.5 ± 0.8 mmol/l, p = .02), exercise performance (+0.40 ± 0.2 vs. +0.2 ± 0.1 W/kg, p = .05) and fat mass (-1.2 ± 1.3 vs. -0.2 ± 1.0 kg, p = .03). In addition, exercise training in the afternoon also tended to elicit superior effects on basal hepatic glucose output (p = .057). Our findings suggest that metabolically compromised subjects may reap more pronounced metabolic benefits from exercise training when this training is performed in the afternoon versus morning. CLINICALTRIALS.GOV ID: NCT01317576.
Chronobiology of exercise: the influence of scheduling upon glycemic responses of control and of subjects with diabetes mellitus. [2011]Exercise programs contribute significantly to: a) improve cardiovascular fitness; b) lower blood pressure in hypertension; and c) facilitate glycemic control in subjects with Diabetes Mellitus (DM). The mechanisms involved in promoting the above responses remain undetermined. Circadian phases at which exercise is applied could play a major role in optimizing the individual's physiological responses to exercise. In a pilot study, controls and a subject with Insulin Dependent Diabetes Mellitus (IDDM) were exercised at 0800 and 2000 hours: pedaling on an exercycle for 30 minutes at rates that maintained tachycardia at 70% of maximum reserve heart rates (Karvomen et al., 1957). All subjects were on "standard" rest-activity schedules (rest 2300-2400 to 0600-0700) and were allowed a single 360 ml Sustacal meal either at 2400 hours or at 1200 hours; i.e., 8 hours preceding the exercise program. Blood samples were obtained for determinations of glucose (finger tip) just before exercise (0 time) and at 10, 20, 30, 40 and 60 minutes of exercise/post exercise periods. The results suggest that non-diabetics experience a rapid decrease in blood glucose levels which does not recover during the 60 minute sampling time when exercise was in the morning. However, when these individuals exercised during the evening, glucose levels did not fall as much on a percentage basis and full recovery was obtained within 40-60 minutes. In the case of the diabetic patient, after morning exercise, glucose levels did not decline and after 40 minutes had risen above resting glucose levels.(ABSTRACT TRUNCATED AT 250 WORDS)
Examining the Role of Exercise Timing in Weight Management: A Review. [2022]Many adults cite exercise as a primary strategy for losing weight, yet exercise alone is modestly effective for weight loss and results in variable weight loss responses. It is possible that some of the variability in weight loss may be explained by the time of day that exercise is performed. Few studies have directly compared the effects of exercise performed at different times of the day (i. e., morning versus evening exercise). Results from these existing studies are mixed with some studies demonstrating superior weight and fat mass loss from morning exercise, while other studies have found that evening exercise may be better for weight management. Exercise timing may alter modifiable lifestyle behaviors involved in weight management, such as non-exercise physical activity, energy intake, and sleep. The purpose of this review is to summarize evidence for and against time-of-day dependent effects of exercise on weight management. Although limited, we also review studies that have examined the effect of exercise timing on other lifestyle behaviors linked to body weight regulation. While exercise at any time of day is beneficial for health, understanding whether there is an optimal time of day to exercise may advance personalized treatment paradigms for weight management.
The role of physical activity in the control of obesity. [2021]An exercise programme is an important part of the management of the obese patient. Exercise may increase both the specific dynamic action of food and the post-exercise metabolic rate, in addition to its direct caloric cost. Moderate daily exercise aids regulation of the appetite and may reduce the voluntary caloric intake of otherwise sedentary persons. Post-prandial activity may utilize more calories; therefore an adequate breakfast and avoidance of late night eating may be effective in weight control. A better tolerated and more nutritious diet may be allowed, and lean body weight better preserved, by combining exercise with a dietary programme. Regular exercise may also reduce some of the more serious life-threatening complications of obesity and poor dietary habits, allowing greater freedom in the pursuit of other pleasures.
Exercise recommendations for patients with type 2 diabetes. [2017]The American College of Sports Medicine and American Diabetes Association recommend that patients with type 2 diabetes participate in at least 150 minutes of moderate exercise weekly with resistance training two or three times weekly. This article reviews the guidelines, preparticipation cardiovascular screening recommendations, and considerations for patients with diabetes and comorbidities who are planning to participate in regular exercise regimens.
Exercise Timing in Type 2 Diabetes Mellitus: A Systematic Review. [2019]The timing of exercise relative to meal consumption has recently been identified as potentially moderating the effectiveness of exercise on glycemic responses in type 2 diabetes mellitus (T2DM). The aim of this study was to systematically review the literature related to exercise timing, relative to meal consumption, and glycemic control in individuals with T2DM.