Colonoscopy Techniques for Inflammatory Bowel Disease

Recruiting in Palo Alto (17 mi)

+1 other location

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Beth Israel Deaconess Medical Center

No Placebo Group

Trial Summary

What is the purpose of this trial?

Inflammatory Bowel Disease (IBD) involving the colon is a known risk for colon cancer. There are two standards-of-care colonoscopy techniques used for screening all patients who suffer from IBD for more than eight years. One method is to obtain random biopsies throughout the colon and the other is by using dye spraying chromo-colonoscopy. This trial aims to study the difference between the two colonoscopy techniques during the era of high definition camera in detecting neoplastic lesions during screening patients with long-standing IBD.

Research Team

Eligibility Criteria

This trial is for adults over 18 with a history of Ulcerative Colitis, Crohn's disease affecting the colon, or unclassified colitis lasting at least eight years, or any duration if also diagnosed with primary sclerosing cholangitis. Participants must have significant colon involvement and not had a total colectomy or recent colonoscopy.

Inclusion Criteria

I have a history of ulcerative colitis, Crohn's disease, or unspecified colitis, with or without a history of colon polyps.

My colon lesion affects more than one-third of it.

I was diagnosed over 8 years ago or have primary sclerosing cholangitis.

See 1 more

Exclusion Criteria

Prior colonoscopy within the last 6 months

Poor bowel preparation

I have had my entire colon removed.

See 4 more

Treatment Details

Interventions

Dye Spraying Chromocolonoscopy (Procedure)
High Definition Colonoscopy (Procedure)

Trial OverviewThe study compares two techniques to screen for cancer in patients with long-term IBD: High Definition Colonoscopy (HDC) versus Dye Spraying Chromocolonoscopy (DSC), using high-definition cameras to detect abnormal growths in the colon.

Participant Groups

2Treatment groups

Experimental Treatment

Active Control

Group I: High Definition White Light ColonoscopyExperimental Treatment1 Intervention

Group II: Dye Spraying Chromo-colonoscopyActive Control1 Intervention