Investigational Imaging Technique for Brain Cancer

Palo Alto (17 mi)

Overseen byJeffrey J. Olson, MD

Age: 18+

Sex: Any

Travel: May be covered

Time Reimbursement: Varies

Trial Phase: N/A

Waitlist Available

Sponsor: Emory University

No Placebo Group

Trial Summary

What is the purpose of this trial?This early phase I trial tests the safety and reliability of an investigational imaging technique called quantitative oblique back illumination microscopy (qOBM) during brain surgery for detecting brain tumors and brain tumor margins in patients with glioblastoma, astrocytoma, or oligodendroglioma. Surgical margins refer to the edge or border of the tissue removed in cancer surgery. qOBM may be able to assess and reveal brain tumor surgical margins in a more safe and reliable manner.

Eligibility Criteria

This trial is for adults (18+) who need brain surgery within the next 14 days for a new or worsening glioblastoma, astrocytoma, or oligodendroglioma. Participants must understand the study's nature and agree to its procedures. Those only needing a needle biopsy or with serious health issues like uncontrolled infection, heart problems, or mental illness that could limit compliance are excluded.

Treatment Details

The trial tests a new imaging technique called quantitative oblique back-illumination microscopy (qOBM) during brain surgery. It aims to safely and reliably identify tumor edges in patients undergoing craniotomy—a surgical procedure to remove part of the skull to access the brain.

1Treatment groups

Experimental Treatment

Group I: Diagnostic (qOBM)Experimental Treatment2 Interventions

Patients undergo craniotomy with intraoperative ex vivo and in situ tumor assessment with qOBM. Patients then undergo postoperative exam with CT or MRI any of days 1-5 after surgery.

Craniotomy is already approved in United States for the following indications:

🇺🇸 Approved in United States as Cs-131 Brachytherapy for: