Trial Summary
What is the purpose of this trial?This pilot study of scalp cooling with Penguin cold caps will examine the effectiveness of scalp cooling to reduce the development of hair loss in 30 participants with multiple myeloma undergoing high-dose chemotherapy with melphalan and autologous peripheral blood stem cell transplant at Cedars-Sinai Medical Center. The investigators will also assess the potential impact of hair loss versus the discomfort and inconvenience of the scalp cooling procedure.
Eligibility Criteria
This trial is for adults over 18 with multiple myeloma who are about to receive high-dose chemotherapy and a stem cell transplant. They must have good performance status, sufficient hair coverage, and be able to follow the study's procedures. People with cold-related diseases, certain skin conditions, spinal or neck injuries, or those using specific medications cannot participate.Inclusion Criteria
My hair covers most of my head.
I am 18 years old or older.
Written informed consent obtained from subject and ability for subject to comply with the requirements of the study
+3 more
Exclusion Criteria
I cannot take melphalan due to health reasons.
I do not have conditions related to cold sensitivity like Reynaud's disease.
Less than 75% of my scalp is covered with hair.
+5 more
Participant Groups
The study tests if Penguin Cold Caps can prevent hair loss in patients undergoing treatment for multiple myeloma. It involves wearing these special caps during chemotherapy sessions at Cedars-Sinai Medical Center to see if they reduce hair loss without causing too much discomfort.
1Treatment groups
Experimental Treatment
Group I: Penguin Cold CapExperimental Treatment1 Intervention
Patients will receive Penguin cold cap: 60 minutes prior to melphalan infusion and continue for 5 hours after melphalan infusion start time, for a total of 6 hours, on Days -2 and -1.
Find a Clinic Near You
Research Locations NearbySelect from list below to view details:
Cedars-Sinai Medical CenterLos Angeles, CA
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Who Is Running the Clinical Trial?
Cedars-Sinai Medical CenterLead Sponsor
Penguin Cold CapsCollaborator