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Neurofeedback for Anorexia Nervosa

N/A
Waitlist Available
Led By Guido Frank, MD
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18-45 years old
Healthy body weight between 90 and 110 % average body weight since puberty
Must not have
Major Medical illness that requires medication or have significant impact on subject's life such as: diabetes, Alzheimer's disease or dementia, stroke, learning disability, mobility disorders, cancer, high blood pressure, etc. (to be determined through biological screening form and interview with principal investigator (PI)
Lifetime history of bipolar disorder or psychosis
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 9 days
Awards & highlights
No Placebo-Only Group

Summary

This trial will explore the neural and behavioral responses of people with Anorexia Nervosa and Atypical Anorexia Nervosa to better understand and develop new treatments for these severe psychiatric illnesses.

Who is the study for?
This trial is for individuals aged 18-45 with Anorexia Nervosa or Atypical Anorexia, who are right-handed (EHI-R LQ > +200), speak English primarily, and women must have a regular menstrual cycle. Excluded are those with psychiatric disorders, substance abuse issues, medical conditions affecting eating/weight, pregnancy/breastfeeding in the last 3 months, contraindications to MRI, or significant head trauma.
What is being tested?
The study aims to understand how stress affects people with anorexia using neurofeedback and psychophysical methods. It will assess neural and behavioral responses to stress in participants with AN or AAN compared to healthy controls within the same age range.
What are the potential side effects?
Since this trial involves non-invasive techniques like neurofeedback and MRI scans rather than medication or invasive procedures, side effects may include discomfort from being in an MRI machine but typically no severe physical side effects are expected.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 45 years old.
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My weight has been within 10% of the average since puberty.
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I am diagnosed with anorexia, fear gaining weight, see my body differently, and haven't had a period in over 3 months.
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I have been diagnosed with Anorexia Nervosa.
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I am between 18 and 45 years old.
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I have been diagnosed with Atypical Anorexia Nervosa.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have a major illness like diabetes or high blood pressure that affects my daily life.
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I have never been diagnosed with bipolar disorder or psychosis.
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I have a history of bipolar I disorder or psychosis.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 9 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 9 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Functional Magnetic Resonance Imaging (fMRI) brain activation in response to stress during a body size estimation task
Functional Magnetic Resonance Imaging (fMRI) brain activation in response to stress during a taste reward task
Secondary study objectives
Ecological Momentary Assessment (EMA)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: BehavioralExperimental Treatment1 Intervention
Negative Affect Task

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,180 Previous Clinical Trials
1,574,756 Total Patients Enrolled
4 Trials studying Eating Disorders
1,568 Patients Enrolled for Eating Disorders
Guido Frank, MDPrincipal InvestigatorUniversity of California, San Diego
5 Previous Clinical Trials
178 Total Patients Enrolled

Media Library

Negative Affect Task Clinical Trial Eligibility Overview. Trial Name: NCT05834816 — N/A
Eating Disorders Research Study Groups: Behavioral
Eating Disorders Clinical Trial 2023: Negative Affect Task Highlights & Side Effects. Trial Name: NCT05834816 — N/A
Negative Affect Task 2023 Treatment Timeline for Medical Study. Trial Name: NCT05834816 — N/A
~200 spots leftby Mar 2029
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