Dietary Supplement for Osteoarthritis

Recruiting in Palo Alto (17 mi)

Overseen by Guangju Zhai, PhD

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: Memorial University of Newfoundland

No Placebo Group

Trial Summary

What is the purpose of this trial?

This study evaluates the effects arginine on osteoarthritis (OA) in adults. Participants will be randomly divided into two groups, taking arginine and nothing, respectively. Outcomes will be evaluated by lab test results on OA joint cartilage and self-administered questionnaires. The hypothesis is that arginine can slow down or reverse OA.

Research Team

Guangju Zhai, PhD

Principal Investigator

Memorial University of Newfoundland

Eligibility Criteria

This trial is for adults with primary knee osteoarthritis who are scheduled for knee replacement surgery within the next 6 months, can walk on their own, and live near St. John's in Canada. It excludes those with other types of arthritis or recent treatments/supplements that could affect results.

Inclusion Criteria

I am scheduled for knee replacement surgery due to arthritis.

I can walk on my own.

Must live in 50 kilometers perimeter of St. John's, capital city of Newfoundland and Labrador, Canada

Exclusion Criteria

I have received treatments like viscosupplementation or PRP injections.

I have had a fracture due to weak bones or knee surgery in the last 6 months.

I haven't taken arginine supplements in the last 6 months.

Treatment Details

Interventions

• L-arginine (Amino Acid)

Trial Overview The study tests if taking arginine supplements affects osteoarthritis progression. Participants will be split into two groups: one taking arginine and the other not taking anything. Their joint health will be monitored through lab tests and questionnaires.

Participant Groups

Group I: Arginine Experimental Treatment 1 Intervention

L-arginine 1.5 g capsule by mouth, once daily for 6 months

Group II: No Intervention Active Control 1 Intervention

no supplement for 6 months

Who Is Running the Clinical Trial?

Memorial University of Newfoundland

Lead Sponsor

Trials

73

Recruited

1,836,000+

Dr. Jennifer Lokash

Memorial University of Newfoundland

Chief Executive Officer

PhD in English Literature

Dr. Ken Fowler

Memorial University of Newfoundland

Chief Medical Officer since 2023

MD

Ocean Frontier Institute

Collaborator

Trials

1

Recruited

40+