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Amino Acid

Dietary Supplement for Osteoarthritis

N/A
Waitlist Available
Led By Guangju Zhai, PhD
Research Sponsored by Memorial University of Newfoundland
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Must be ambulatory
Be older than 18 years old
Must not have
Use of Intra-articular viscosupplementation or platelet rich plasma at any point
Use of bisphosphonates within 2 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 20 months
Awards & highlights
No Placebo-Only Group

Summary

This trial will test whether or not arginine can help with osteoarthritis by looking at cartilage health and participant symptoms.

Who is the study for?
This trial is for adults with primary knee osteoarthritis who are scheduled for knee replacement surgery within the next 6 months, can walk on their own, and live near St. John's in Canada. It excludes those with other types of arthritis or recent treatments/supplements that could affect results.
What is being tested?
The study tests if taking arginine supplements affects osteoarthritis progression. Participants will be split into two groups: one taking arginine and the other not taking anything. Their joint health will be monitored through lab tests and questionnaires.
What are the potential side effects?
While specific side effects aren't listed, dietary supplements like arginine may cause gastrointestinal discomfort, allergies, changes in blood pressure, or interact with certain medications.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I can walk on my own.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have received treatments like viscosupplementation or PRP injections.
Select...
I have used bisphosphonates in the last 2 years.
Select...
I have been diagnosed with secondary osteoarthritis or inflammatory arthritis.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 20 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 20 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Target Gene Expressions in Osteoarthritic Knee Cartilage after 6 Months of Supplementation
Secondary study objectives
Knee
SF-36 to Measure Changes in Physical and Mental Function between baseline and at 12 Months Post-surgery
SF-36 to Measure Changes in Physical and Mental Function between baseline and at 6 Months
+4 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: ArginineExperimental Treatment1 Intervention
L-arginine 1.5 g capsule by mouth, once daily for 6 months
Group II: No InterventionActive Control1 Intervention
no supplement for 6 months
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
L-arginine
2016
Completed Phase 4
~1380

Find a Location

Who is running the clinical trial?

Memorial University of NewfoundlandLead Sponsor
70 Previous Clinical Trials
1,836,001 Total Patients Enrolled
2 Trials studying Osteoarthritis
330 Patients Enrolled for Osteoarthritis
Ocean Frontier InstituteUNKNOWN
Guangju Zhai, PhDPrincipal InvestigatorMemorial University of Newfoundland

Media Library

L-arginine (Amino Acid) Clinical Trial Eligibility Overview. Trial Name: NCT03665116 — N/A
Osteoarthritis Research Study Groups: Arginine, No Intervention
Osteoarthritis Clinical Trial 2023: L-arginine Highlights & Side Effects. Trial Name: NCT03665116 — N/A
L-arginine (Amino Acid) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03665116 — N/A
~6 spots leftby Nov 2025
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