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Brain Activity Study for Cognitive Impairment in Parkinson's Disease

N/A

Recruiting

Led By Sarah Bick, MD

Research Sponsored by Vanderbilt University Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Age greater than or equal to 40

Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center

Must not have

Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)

Age less than 40

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline to end of deep brain stimulation (dbs), approximately 3-4 hours

Awards & highlights

No Placebo-Only Group

Summary

This trial will study the brain activity of people with Parkinson's disease in order to better understand the cognitive impairments associated with the condition.

Who is the study for?

This trial is for English-speaking Parkinson's disease patients over 40, who are scheduled for deep brain stimulation surgery at Vanderbilt University Medical Center. Participants must be able to undergo intraoperative testing and have a clinical electrode trajectory that contacts the caudate.

What is being tested?

The study aims to understand cognitive impairment in Parkinson's by recording brain activity from corticostriatal structures during deep brain stimulation surgery. It will measure neural activity associated with nonmotor symptoms of the disease.

What are the potential side effects?

Since this trial involves neurophysiology recordings and neural stimulation during surgery, potential side effects may include typical surgical risks like infection or bleeding, as well as any specific reactions related to deep brain stimulation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 40 years old or older.

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I am scheduled for deep brain stimulation surgery at Vanderbilt under local anesthesia.

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I have been diagnosed with Parkinson's disease.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am unable to follow instructions or directions during surgery.

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I am under 40 years old.

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I have a movement disorder that is not Parkinson's disease.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline to end of deep brain stimulation (dbs), approximately 3-4 hours

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline to end of deep brain stimulation (dbs), approximately 3-4 hours

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to end of deep brain stimulation (dbs), approximately 3-4 hours for reporting.