What is the mechanism of action of this treatment?

The most common treatments for Multiple Sclerosis (MS) include disease-modifying therapies (DMTs) such as interferons, glatiramer acetate, and oral agents like dimethyl fumarate. These treatments work by modulating the immune system to reduce inflammation and prevent immune cells from attacking the myelin sheath, which is crucial for nerve function. This is important for MS patients as it helps to slow disease progression, reduce relapse rates, and manage symptoms. The MS Falls Insight Track (MS FIT) application complements these treatments by enabling patients to log their symptoms, visualize their health data, communicate with their care team, and access educational materials, thereby enhancing their ability to manage the disease effectively.

What side effects are associated with this type of intervention?

Common treatments for Multiple Sclerosis (MS) include interferon beta-1a, interferon beta-1b, and fingolimod. Interferon beta-1a and beta-1b can cause side effects such as injection site reactions (e.g., abscess, cellulitis, necrosis), flu-like symptoms (which may be managed with ibuprofen or acetaminophen), and potential liver dysfunction. Depression has also been reported as a possible adverse effect. Fingolimod is associated with side effects including macular edema, increased risk of infections (e.g., varicella-zoster virus, cryptococcal infections), and progressive multifocal leukoencephalopathy (PML). Patients may also experience severe relapses upon cessation of fingolimod treatment.

What prior FDA approvals exist?

FDA-approved treatments for Multiple Sclerosis include interferon beta-1a and beta-1b, glatiramer acetate, and natalizumab. These treatments have shown efficacy in reducing relapse rates and slowing disease progression. The MS Falls Insight Track (MS FIT) application complements these treatments by providing digital tools for logging falls, visualizing MS-related data, facilitating communication with healthcare providers, and delivering educational content. This holistic approach aims to enhance patient management and adherence to treatment plans, ultimately improving outcomes for individuals with MS.

What other types of research exist?

Promising alternatives to the MS Falls Insight Track (MS FIT) application for Multiple Sclerosis patients in 2024 include: 1) Telemedicine platforms with integrated MS-specific modules for remote monitoring and communication, such as the Veterans Affairs Neuropathy Scale for remote polyneuropathy exams. 2) Mobile health applications that offer comprehensive management of MS symptoms, including fatigue management and fall prevention, similar to the MS INFoRM website. 3) Wearable devices that track physical activity, sleep patterns, and other health metrics, providing real-time data visualization and alerts. 4) AI-driven platforms that personalize educational content and treatment plans based on patient data and behavior patterns. These alternatives leverage advanced technologies to provide holistic and personalized care for MS patients.

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MS FIT App for Multiple Sclerosis (MS FIT Trial)

N/A

Recruiting

Led By Riley Bove, MD

Research Sponsored by University of California, San Francisco

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12 months

Awards & highlights

No Placebo-Only Group

Summary

This trial tests the MS FIT app, which helps MS patients track falls, view health data, and get fall prevention tips. It targets MS patients because they often experience falls that affect their daily lives. The app uses data from health records, wearables, and surveys to monitor falls and provide personalized advice.

Who is the study for?

This trial is for California residents aged 18 or older with Multiple Sclerosis, who can walk with assistance but may use a wheelchair. They should have fallen before or be at risk of falling and must be able to connect to Wi-Fi at home or work. People with cognitive or visual impairments that make it hard to follow the study plan cannot join.

What is being tested?

The study is testing an app called MS FIT designed for MS patients to track falls, see their health data, talk to their care team about fall risks, and get information on preventing falls.

What are the potential side effects?

Since this trial involves using an application rather than medication, there are no direct medical side effects; however, participants may experience frustration or stress if they encounter technical difficulties.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Percentage of patient-clinician encounters initially use the tool (Adoption)

Percentage of patient-clinician encounters use the tool during the 12-month visit (Engagement)

Percentage of patients initially use the tool (Adoption)

+2 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: MS FIT: Falls Insight TrackExperimental Treatment1 Intervention

Participants in this arm will receive 12 months use of MS FIT mobile tool intervention

Do I qualify?Apply below to find out

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

The most common treatments for Multiple Sclerosis (MS) include disease-modifying therapies (DMTs) such as interferons, glatiramer acetate, and oral agents like dimethyl fumarate. These treatments work by modulating the immune system to reduce inflammation and prevent immune cells from attacking the myelin sheath, which is crucial for nerve function. This is important for MS patients as it helps to slow disease progression, reduce relapse rates, and manage symptoms. The MS Falls Insight Track (MS FIT) application complements these treatments by enabling patients to log their symptoms, visualize their health data, communicate with their care team, and access educational materials, thereby enhancing their ability to manage the disease effectively.