Resistance Training for Prostate Cancer

Recruiting in Palo Alto (17 mi)

Age: 18+

Sex: Male

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Waitlist Available

Sponsor: University of Toronto

No Placebo Group

Trial Summary

What is the purpose of this trial?

Prostate cancer and its treatment are associated with many long-term adverse effects including cancer-related cognitive impairment. Specifically, androgen deprivation therapy has been shown to negatively impact cognitive function. Combined aerobic and resistance training has been shown to improve cognitive function in men treated with androgen deprivation therapy, but limited research has observed its impact into survivorship. Additionally, existing study designs are limited to supervised, combined aerobic and resistance training interventions. Remotely-delivered resistance training programs could enhance exercise participation by overcoming commonly reported barriers in men living with and beyond prostate cancer such as transportation, distance to facility, and timing of programs. Alongside the needs to address cancer-related cognitive impairments due to androgen deprivation therapy, resistance training may serve to manage functional deficits, losses in bone mineral density and muscle mass and increases in cardiometabolic risk factors. This study will assess the feasibility of an 8-week remotely-delivered resistance training program to improve cognitive function in men living with and beyond prostate cancer who have a history of androgen deprivation therapy treatment.

Research Team

Eligibility Criteria

This trial is for men who have or had prostate cancer and were treated with androgen deprivation therapy. It's designed to see if working out at home with resistance training can help improve their thinking skills, which may be affected by their treatment.

Inclusion Criteria

Not physically active (self-report <90 minutes of MVPA/week and <2 days of RT/week)

I am not currently receiving radiation therapy.

I have prostate cancer with minimal or no symptoms and have been treated with hormone therapy.

Exclusion Criteria

I have another type of cancer besides the one being treated.

Have experienced a fall in the last 12 months

Current participation in other exercise programs/trials

Treatment Details

Interventions

• Remotely-Delivered Resistance Training Program (Behavioral Intervention)

Trial Overview The study tests an 8-week program where participants do resistance exercises at home. The goal is to find out if this type of exercise can help manage cognitive issues that sometimes happen after prostate cancer treatments.

Participant Groups

Group I: Resistance Training Experimental Treatment 1 Intervention

The resistance training intervention will consist of two remotely-delivered exercise sessions per week for eight weeks (16 sessions total). One session will be a live, remotely delivered 1:1 class led by a qualified exercise professional (\~one hour). The second session will be unsupervised, completed by watching a pre-recorded workout video that will vary bi-weekly to elicit progressive overload. Pre-recorded workout videos will be emailed and feature the qualified exercise professional who will provide instruction to mimic live sessions. Both sessions will involve a dynamic warm-up (\~10 minutes), 8 resistance-band exercises (\~30-45 minutes), followed by a cool-down (\~10 minutes).

Group II: Usual Care Active Control 1 Intervention

The usual care group will receive exercise guidelines for cancer survivors (i.e., educational material) from the American College of Sport Medicine. Exercise guidelines materials will be provided through email.

Who Is Running the Clinical Trial?

University of Toronto

Lead Sponsor

Trials

739

Recruited

1,125,000+

Allison Brown

University of Toronto

Chief Medical Officer

PhD in Chemical Engineering from the University of Toronto

Michael Sefton

University of Toronto

Chief Executive Officer since 2017

PhD in Chemical Engineering from the University of Toronto and MIT