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Circulation Evaluation Techniques for Sepsis (DAISY Trial)

N/A
Recruiting
Research Sponsored by Denver Health and Hospital Authority
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 90 day
Awards & highlights
No Placebo-Only Group

Summary

This trial aims to understand how eGC breakdown can influence HI to help develop better resuscitation treatments. HVM & biomarkers will be used to serially evaluate MiH & eGC.

Who is the study for?
This trial is for adults diagnosed with sepsis or septic shock who need to be admitted to the hospital. It also includes a control group of adults undergoing elective surgery that requires intubation and general anesthesia.
What is being tested?
The study aims to understand how well handheld vital microscopy can predict outcomes in patients by looking at tiny blood vessels under the tongue and measuring substances in the urine that indicate blood vessel health.
What are the potential side effects?
Since this trial involves non-invasive monitoring techniques like ultrasound, passive leg raises, and sublingual microscopy, side effects are minimal but may include discomfort from the procedures.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~90 day
This trial's timeline: 3 weeks for screening, Varies for treatment, and 90 day for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Initiation and Duration Renal Replacement Therapy
Secondary study objectives
Rate of 90 day survival
Rate of Inpatient Mortality

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Septic Patient InterventionsExperimental Treatment4 Interventions
Septic Patients will have all interventions performed: Urine collection, Passive Leg Raise, Ultrasound and sublingual microscopy
Group II: Control Patient InterventionsExperimental Treatment2 Interventions
Control patients will have urine collection and sublingual microscopy performed when intubated

Find a Location

Who is running the clinical trial?

National Institutes of Health (NIH)NIH
2,840 Previous Clinical Trials
8,171,968 Total Patients Enrolled
13 Trials studying Sepsis
9,581 Patients Enrolled for Sepsis
Denver Health and Hospital AuthorityLead Sponsor
104 Previous Clinical Trials
401,970 Total Patients Enrolled
1 Trials studying Sepsis
57 Patients Enrolled for Sepsis
~0 spots leftby Dec 2024
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