Your session is about to expire
← Back to Search
Negative Emotions Impact on Decision-Making
N/A
Recruiting
Led By Silvia Lopez Guzman, M.D.
Research Sponsored by National Institute of Mental Health (NIMH)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up right after intervention
Awards & highlights
No Placebo-Only Group
Summary
This trial will study how negative emotions affect thinking and decision-making in healthy people to better understand mental disorders.
Who is the study for?
Healthy adults aged 18 to 55 who can understand and sign consent, read and write English. Excluded are those using psychoactive drugs or corticosteroids, pregnant women, NIMH staff/family, people with chronic pain or metal in the body that affects MRI scans, left-handed individuals for certain tests, and anyone with medical conditions affecting the study.
What is being tested?
The trial studies how negative emotions like stress, pain, and craving influence decision-making. Participants undergo emotional stressors (videos, math problems, heat/cold exposure), fill out questionnaires about their state of mind and personality traits while some also perform tasks during an fMRI brain scan.
What are the potential side effects?
There may not be direct side effects from the interventions as they involve non-invasive procedures such as watching videos or solving arithmetic problems. However discomfort from heat application or cold immersion could occur.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ right after intervention
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~right after intervention
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
BOLD signal in decision-making areas ROI
Value-based decision-making metrics
Secondary study objectives
Confidence
Interoceptive accuracy
Awards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
5Treatment groups
Experimental Treatment
Group I: 5Experimental Treatment1 Intervention
within-subjects experimental study, where each subject will receive a neutral state and a negative state induction intervention in a cross-over design (counterbalanced order across participants).
Group II: 4Experimental Treatment1 Intervention
within-subjects experimental study, where each subject will receive a neutral state and a negative state induction intervention in a cross-over design (counterbalanced order across participants).
Group III: 3Experimental Treatment1 Intervention
within-subjects experimental study, where each subject will receive a neutral state and a negative state induction intervention in a cross-over design (counterbalanced order across participants).
Group IV: 2Experimental Treatment1 Intervention
within-subjects experimental study, where each subject will receive a neutral state and a negative state induction intervention in a cross-over design (counterbalanced order across participants).
Group V: 1Experimental Treatment1 Intervention
within-subjects experimental study, where each subject will receive a neutral state and a negative state induction intervention in a cross-over design (counterbalanced order across participants).
Find a Location
Who is running the clinical trial?
National Institute of Mental Health (NIMH)Lead Sponsor
2,918 Previous Clinical Trials
2,739,233 Total Patients Enrolled
5 Trials studying Emotions
581 Patients Enrolled for Emotions
Silvia Lopez Guzman, M.D.Principal InvestigatorNational Institute of Mental Health (NIMH)
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have scars, burns, or a recent tattoo that could affect skin sensitivity in the test area.I have or had a pain condition lasting more than six months.I am currently on a diet or strongly wish to start one that reduces carbs.I understand my participation will help ensure diversity in the study.I am between 18 and 55 years old.I have a health condition that makes fasting for 4-6 hours risky.I regularly use corticosteroids.I have a health condition that might affect my sensitivity to temperature or pain.I have a condition that affects my sense of touch or circulation.I regularly use medication that affects my pain or heat perception.
Research Study Groups:
This trial has the following groups:- Group 1: 2
- Group 2: 3
- Group 3: 1
- Group 4: 4
- Group 5: 5
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Other Trials to Consider
Popular Categories
Learn More About These Treatments
Share this study with friends
Copy Link
Messenger