Light Therapy + Occupational Therapy for Genitourinary Cancers

Recruiting in Palo Alto (17 mi)

Overseen by William Dale

Age: 18+

Sex: Any

Travel: May Be Covered

Time Reimbursement: Varies

Trial Phase: Academic

Recruiting

Sponsor: City of Hope Medical Center

Disqualifiers: Severe sleep disorders, Eye diseases, Severe psychological impairment, others

No Placebo Group

Approved in 4 Jurisdictions

Trial Summary

What is the purpose of this trial?

This clinical trial evaluates light therapy and occupational therapy in improving cancer related fatigue (CRF) patients with genitourinary cancers. Light therapy is a non-pharmacological and evidence-based intervention for managing fatigue in cancer patients. The use of light therapy can provide a low burden, inexpensive, and easy to disseminate intervention approach that can potentially have a larger impact on CRF. In addition, occupational therapy is a standard, but often underutilized, component of the multi-disciplinary approach to cancer care. Using the combination of light therapy and occupational therapy may be effective in CRF management.

Do I need to stop my current medications for this trial?

The trial protocol does not specify whether you need to stop taking your current medications. However, since the trial involves light and occupational therapy, it seems likely that you can continue your existing treatments, especially since participants must be on active cancer treatment.

What data supports the effectiveness of the treatment Light Therapy + Occupational Therapy for Genitourinary Cancers?

Research shows that occupational therapy can improve the quality of life for cancer patients by helping them engage in daily activities more independently. This suggests that combining occupational therapy with light therapy might offer benefits for patients with genitourinary cancers. ^{1 2 3 4 5}

How does the treatment of light therapy combined with occupational therapy for genitourinary cancers differ from other treatments?

This treatment is unique because it combines light therapy, which uses specific wavelengths of light to potentially improve mood and energy, with occupational therapy, which helps patients regain skills and improve their quality of life. Unlike standard drug treatments like androgen deprivation therapy (ADT) for prostate cancer, which can have significant side effects, this approach focuses on enhancing overall well-being and daily functioning. ^{6 7 8 9 10}

Research Team

William Dale

Principal Investigator

City of Hope Medical Center

Eligibility Criteria

This trial is for adults over 18 with genitourinary cancers like prostate, kidney, and bladder cancer who are experiencing mild to moderate fatigue during treatment. They must speak English well enough to consent and have a life expectancy of at least six months. People with severe sleep disorders, psychological impairments, recent eye surgery or diseases affecting light processing in the eyes, sensitivity to light or seizures cannot participate.

Inclusion Criteria

Sufficiently fluent in English

I am willing and able to agree to participate on my own.

I am currently undergoing treatment such as chemotherapy, immunotherapy, or radiotherapy.

Exclusion Criteria

Severe psychological impairment (e.g., bipolar disorder or manic episodes)

I have a severe sleep disorder like narcolepsy.

I have used light therapy for fatigue or depression.

Trial Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive light therapy and/or occupational therapy interventions for 3 months

3 months

6 follow-up sessions

Follow-up

Participants are monitored for safety and effectiveness after treatment

3 months

Treatment Details

Interventions

• Bright White Light Therapy (Procedure)
• Occupational Therapy (Behavioral Intervention)

Trial Overview The study is testing whether combining bright white light therapy with occupational therapy can help reduce fatigue in patients undergoing treatment for genitourinary cancers. Light therapy is simple and low-cost while occupational therapy helps manage daily activities; together they might improve energy levels.

Participant Groups

Group I: Arm III (OT, BWL) Experimental Treatment 3 Interventions

Patients self-administer 30 minutes of light delivered via light glasses every morning for 3 months. Patients attend 6 follow up sessions to address any questions regarding the wearable light therapy glasses and to complete the occupational therapist-led session over 60 minutes.

Group II: Arm II (OT) Experimental Treatment 2 Interventions

Patients undergo 6 occupational therapist-led sessions over 60 minutes each.

Group III: Arm I (BWL) Experimental Treatment 2 Interventions

Patients self-administer 30 minutes of light delivered via light glasses every morning for 3 months. Patients attend 6 follow up sessions to address any questions regarding the wearable light therapy glasses.

Group IV: Arm IV (Control) Active Control 2 Interventions

Patients undergo routine treatment and usual follow up care with their medical oncologist.

Occupational Therapy is already approved in Canada for the following indications:

Approved in Canada as Occupational Therapy for:

• Rehabilitation
• Physical disabilities
• Mental health conditions
• Cancer-related fatigue

Find a Clinic Near You

Research Locations Nearby Select from list below to view details:

City of Hope Medical Center Duarte, CA

Who Is Running the Clinical Trial?

City of Hope Medical Center

Lead Sponsor

Trials

614

Patients Recruited

1,924,000+

National Cancer Institute (NCI)

Collaborator

Trials

14080

Patients Recruited

41,180,000+

Findings from Research

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Older Adults with Cancer: A Randomized Controlled Trial of Occupational and Physical Therapy. Pergolotti, M., Deal, AM., Williams, GR., et al.[2021]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Reasons for and outcome of occupational therapy consultation and treatment in the context of multidisciplinary cancer rehabilitation; a historical cohort study. Rijpkema, C., Duijts, SFA., Stuiver, MM.[2021]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effects of occupational therapy on quality of life of patients with metastatic prostate cancer. A randomized controlled study. Huri, M., Huri, E., Kayihan, H., et al.[2023]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Occupational therapy intervention for cancer patients following hospital discharge: How and when should we intervene? A systematic review. Taylor, S., Keesing, S., Wallis, A., et al.[2021]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Occupational Therapy for Adults With Cancer: Why It Matters. Pergolotti, M., Williams, GR., Campbell, C., et al.[2022]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Optimizing outcomes and quality of life in the hormonal treatment of prostate cancer. Mottet, N., Prayer-Galetti, T., Hammerer, P., et al.[2006]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Depression and androgen deprivation therapy for prostate cancer: a prospective controlled study. Hervouet, S., Savard, J., Ivers, H., et al.[2018]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Lower urinary tract symptoms in patients with advanced prostate cancer: What are the outcomes of androgen deprivation therapy? Akpayak, IC., Shuaibu, SI., Ofoha, CG., et al.[2022]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Combination of Radiation Therapy and Short-Term Androgen Blockade With Abiraterone Acetate Plus Prednisone for Men With High- and Intermediate-Risk Localized Prostate Cancer. Koontz, BF., Hoffman, KE., Halabi, S., et al.[2021]

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Prospective assessment of the quality of life before, during and after image guided intensity modulated radiotherapy for prostate cancer. Sveistrup, J., Mortensen, OS., Bjørner, JB., et al.[2018]

References

1. United States pubmed.ncbi.nlm.nih.gov

Older Adults with Cancer: A Randomized Controlled Trial of Occupational and Physical Therapy. [2021]

2. Australia pubmed.ncbi.nlm.nih.gov

Reasons for and outcome of occupational therapy consultation and treatment in the context of multidisciplinary cancer rehabilitation; a historical cohort study. [2021]

3. Saudi Arabia pubmed.ncbi.nlm.nih.gov

Effects of occupational therapy on quality of life of patients with metastatic prostate cancer. A randomized controlled study. [2023]

4. Australia pubmed.ncbi.nlm.nih.gov

Occupational therapy intervention for cancer patients following hospital discharge: How and when should we intervene? A systematic review. [2021]

5. England pubmed.ncbi.nlm.nih.gov

Occupational Therapy for Adults With Cancer: Why It Matters. [2022]

6. England pubmed.ncbi.nlm.nih.gov

Optimizing outcomes and quality of life in the hormonal treatment of prostate cancer. [2006]

7. United States pubmed.ncbi.nlm.nih.gov

Depression and androgen deprivation therapy for prostate cancer: a prospective controlled study. [2018]

8. Nigeria pubmed.ncbi.nlm.nih.gov

Lower urinary tract symptoms in patients with advanced prostate cancer: What are the outcomes of androgen deprivation therapy? [2022]

9. United States pubmed.ncbi.nlm.nih.gov

Combination of Radiation Therapy and Short-Term Androgen Blockade With Abiraterone Acetate Plus Prednisone for Men With High- and Intermediate-Risk Localized Prostate Cancer. [2021]

10. England pubmed.ncbi.nlm.nih.gov

Prospective assessment of the quality of life before, during and after image guided intensity modulated radiotherapy for prostate cancer. [2018]