Popular Trials
MEK Inhibitor
AZD6244 + Chemotherapy for Advanced Cancer
This study is evaluating whether a combination of AZD6244 given orally twice a day with standard doses of selected chemotherapies will be safe and tolerable for cancer patients with advanced solid tumors. The highest tolerated dose of AZD6244 in combination with selected chemotherapies will be evaluated
Imaging
Tomosynthesis vs. Contrast-Enhanced Mammography for Breast Cancer
This trial aims to see if using contrast-enhanced mammography (CEM) can better detect breast cancer in women who have had it before. CEM uses a special dye to make cancerous tissues more visible on the mammogram. The goal is to improve detection rates without significantly increasing false positives. Contrast-enhanced mammography (CEM) is an imaging tool for breast cancer detection that combines conventional mammography with a special dye to improve cancer detection.
DHODH Inhibitor
Leflunomide for Triple Negative Breast Cancer
This trial is testing the safety and effectiveness of leflunomide, a daily oral medication, in women with aggressive triple negative breast cancer. The drug aims to block a substance that helps cancer cells grow. The study focuses on women who have already tried other treatments.
Popular Filters
Trials for Breast Cancer Patients
PD-L1 Inhibitor
Durvalumab + Olaparib + Cediranib for Ovarian Cancer
This trial is testing the combination of Durvalumab, Olaparib, and Cediranib in adults with advanced or recurrent ovarian cancer to see how well they tolerate it and if it is effective in treating the cancer.
Hormone Therapy
Endocrine Therapy for Low-Risk Breast Cancer
This trial is testing if hormone therapy alone can effectively treat breast cancer in women aged 70 or older with certain types of tumors. The therapy works by blocking estrogen, which helps stop cancer cells from growing. Researchers believe this approach could be enough to control the cancer without needing more aggressive treatments.
Hormone Therapy
Endocrine Therapy Without Radiotherapy for Breast Cancer
This trial will study whether it's safe to forgo radiation treatment after lumpectomy surgery for postmenopausal women with hormone-positive, Her2-negative tumors who have a low risk of cancer recurrence.
CDK4/6 Inhibitor
Abemaciclib + Fulvestrant for Breast Cancer
This trial is comparing two treatments for hormone receptor positive, HER2 negative advanced breast cancer. One group will receive abemaciclib + fulvestrant, and the other will just receive fulvestrant. The study will last about 9 months for each participant.
CDK4/6 Inhibitor
Abemaciclib Combination Therapy for Advanced Breast Cancer
This trial is testing the safety of abemaciclib when used with other treatments for patients whose breast cancer has spread. Abemaciclib helps to stop cancer cells from growing by blocking certain proteins they need. The study aims to find out if this combination is safe for patients with advanced breast cancer.
Trials for Ductal Carcinoma Patients
PD-L1 Inhibitor
Durvalumab + Olaparib + Cediranib for Ovarian Cancer
This trial is testing the combination of Durvalumab, Olaparib, and Cediranib in adults with advanced or recurrent ovarian cancer to see how well they tolerate it and if it is effective in treating the cancer.
Hormone Therapy
Endocrine Therapy for Low-Risk Breast Cancer
This trial is testing if hormone therapy alone can effectively treat breast cancer in women aged 70 or older with certain types of tumors. The therapy works by blocking estrogen, which helps stop cancer cells from growing. Researchers believe this approach could be enough to control the cancer without needing more aggressive treatments.
Hormone Therapy
Endocrine Therapy Without Radiotherapy for Breast Cancer
This trial will study whether it's safe to forgo radiation treatment after lumpectomy surgery for postmenopausal women with hormone-positive, Her2-negative tumors who have a low risk of cancer recurrence.
CDK4/6 Inhibitor
Abemaciclib + Fulvestrant for Breast Cancer
This trial is comparing two treatments for hormone receptor positive, HER2 negative advanced breast cancer. One group will receive abemaciclib + fulvestrant, and the other will just receive fulvestrant. The study will last about 9 months for each participant.
CDK4/6 Inhibitor
Abemaciclib Combination Therapy for Advanced Breast Cancer
This trial is testing the safety of abemaciclib when used with other treatments for patients whose breast cancer has spread. Abemaciclib helps to stop cancer cells from growing by blocking certain proteins they need. The study aims to find out if this combination is safe for patients with advanced breast cancer.
Trials for ER Positive Patients
Hormone Therapy
Endocrine Therapy for Low-Risk Breast Cancer
This trial is testing if hormone therapy alone can effectively treat breast cancer in women aged 70 or older with certain types of tumors. The therapy works by blocking estrogen, which helps stop cancer cells from growing. Researchers believe this approach could be enough to control the cancer without needing more aggressive treatments.
Hormone Therapy
Endocrine Therapy Without Radiotherapy for Breast Cancer
This trial will study whether it's safe to forgo radiation treatment after lumpectomy surgery for postmenopausal women with hormone-positive, Her2-negative tumors who have a low risk of cancer recurrence.
CDK4/6 Inhibitor
Abemaciclib Combination Therapy for Advanced Breast Cancer
This trial is testing the safety of abemaciclib when used with other treatments for patients whose breast cancer has spread. Abemaciclib helps to stop cancer cells from growing by blocking certain proteins they need. The study aims to find out if this combination is safe for patients with advanced breast cancer.
Chemotherapy
Personalized Adaptive Novel Agents for Breast Cancer
This trial is testing new medicines along with regular cancer treatment to find the best combinations for breast cancer patients. It focuses on identifying which treatments work best based on specific cancer characteristics. Early signs of success are monitored using MRI scans and tests on blood and tissue samples.
Trials for PR Positive Patients
Hormone Therapy
Endocrine Therapy Without Radiotherapy for Breast Cancer
This trial will study whether it's safe to forgo radiation treatment after lumpectomy surgery for postmenopausal women with hormone-positive, Her2-negative tumors who have a low risk of cancer recurrence.
CDK4/6 Inhibitor
Abemaciclib Combination Therapy for Advanced Breast Cancer
This trial is testing the safety of abemaciclib when used with other treatments for patients whose breast cancer has spread. Abemaciclib helps to stop cancer cells from growing by blocking certain proteins they need. The study aims to find out if this combination is safe for patients with advanced breast cancer.
Chemotherapy
Personalized Adaptive Novel Agents for Breast Cancer
This trial is testing new medicines along with regular cancer treatment to find the best combinations for breast cancer patients. It focuses on identifying which treatments work best based on specific cancer characteristics. Early signs of success are monitored using MRI scans and tests on blood and tissue samples.
Monoclonal Antibodies
Combination Therapy for Breast Cancer
This trial is testing a new combination of drugs to treat metastatic hormone receptor-positive, HER2-positive breast cancer. The goal is to establish the safety and efficacy of this new combination and to examine potential biomarkers of response to the treatment.
Monoclonal Antibodies
Pembrolizumab + Chemotherapy for Breast Cancer
This trial will assess if pembrolizumab, when combined with chemotherapy, is more effective in treating hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer than chemotherapy alone. The primary hypotheses are that the combination of pembrolizumab and chemotherapy is superior to placebo and chemotherapy in regards to Progression-Free Survival (PFS) or overall survival (OS) in participants with programmed cell death-ligand 1 (PD-L1) combined positive score (CPS) ≥1 and ≥10.
Chemotherapy
Focused Ultrasound + Gemcitabine for Breast Cancer
This trial will test whether focused ultrasound ablation, low-dose gemcitabine, or a combination of the two can help early-stage breast cancer patients by affecting cells in the immune system. The hypothesis is that the combination of the two will be more effective and have fewer negative side effects than either treatment alone.
Phase 3 Trials
CDK4/6 Inhibitor
Abemaciclib + Fulvestrant for Breast Cancer
This trial is comparing two treatments for hormone receptor positive, HER2 negative advanced breast cancer. One group will receive abemaciclib + fulvestrant, and the other will just receive fulvestrant. The study will last about 9 months for each participant.
Selective Estrogen Receptor Downregulator (SERD)
Imlunestrant + Abemaciclib for Breast Cancer
This trial is testing a new drug called imlunestrant, alone and in combination with another drug, abemaciclib, for patients with advanced breast cancer that is ER+ and HER2-. Imlunestrant works by blocking estrogen receptors on cancer cells, while abemaciclib stops the cells from multiplying. The goal is to see if these treatments work better than standard hormone therapy.
Monoclonal Antibodies
Pembrolizumab + Chemotherapy for Breast Cancer
This trial will assess if pembrolizumab, when combined with chemotherapy, is more effective in treating hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer than chemotherapy alone. The primary hypotheses are that the combination of pembrolizumab and chemotherapy is superior to placebo and chemotherapy in regards to Progression-Free Survival (PFS) or overall survival (OS) in participants with programmed cell death-ligand 1 (PD-L1) combined positive score (CPS) ≥1 and ≥10.
Trials With No Placebo
PD-L1 Inhibitor
Durvalumab + Olaparib + Cediranib for Ovarian Cancer
This trial is testing the combination of Durvalumab, Olaparib, and Cediranib in adults with advanced or recurrent ovarian cancer to see how well they tolerate it and if it is effective in treating the cancer.
Hormone Therapy
Endocrine Therapy for Low-Risk Breast Cancer
This trial is testing if hormone therapy alone can effectively treat breast cancer in women aged 70 or older with certain types of tumors. The therapy works by blocking estrogen, which helps stop cancer cells from growing. Researchers believe this approach could be enough to control the cancer without needing more aggressive treatments.
Hormone Therapy
Endocrine Therapy Without Radiotherapy for Breast Cancer
This trial will study whether it's safe to forgo radiation treatment after lumpectomy surgery for postmenopausal women with hormone-positive, Her2-negative tumors who have a low risk of cancer recurrence.
CDK4/6 Inhibitor
Abemaciclib Combination Therapy for Advanced Breast Cancer
This trial is testing the safety of abemaciclib when used with other treatments for patients whose breast cancer has spread. Abemaciclib helps to stop cancer cells from growing by blocking certain proteins they need. The study aims to find out if this combination is safe for patients with advanced breast cancer.
View More Related Trials
Frequently Asked Questions
Introduction to her2 positive breast cancer
What are the top hospitals conducting her2 positive breast cancer research?
Cutting-edge research and clinical trials are crucial in the quest to conquer her2 positive breast cancer, a subtype known for its aggressive nature. In Boston, Dana-Farber Cancer Institute leads the charge with nine active trials dedicated specifically to her2 positive breast cancer. These trials build upon an impressive history of 218 completed studies since their first recorded trial back in 1998. Not far behind, Memorial Sloan Kettering Cancer Center in New york has seven ongoing trials and an astounding 219 all-time her2 positive breast cancer studies under their belt. Their pioneering efforts date back to 1994, firmly establishing them as a key player in this field.
The Mayo Clinic in Rochester also contributes significantly to understanding and treating her2 positive breast cancer, currently conducting six active clinical trials focused on this specific subtype. With a legacy of 117 previously conducted studies dating back to their first recorded trial in 1998, they continue to make strides towards advancements against this challenging form of breast cancer. In sunny Fort Myers, Florida Cancer Specialists is making noteworthy progress as well with six active clinical trials targeting her2 positive breast cancer. While they have conducted fewer all-time trials than some other institutions (36 total), their dedication since recording their first trial in 1995 cannot be underestimated.
Finally, Florida Cancer Specialists' Saint Petersburg location may be relatively new compared to others on this list but it is equally committed with six ongoing clinical trials solely devoted to combating her2 positive breast cancer; having started at2013-with fifteen previous attempts they are paving the way for future breakthroughs within this evolving field.
These hospitals across different locations signify the collaborative effort required for significant medical advancements aimed at improving outcomes for individuals battling her2 positive breast cancer worldwide
Which are the best cities for her2 positive breast cancer clinical trials?
When it comes to her2 positive breast cancer clinical trials, several cities emerge as frontrunners in research and development. Boston, Massachusetts leads the pack with 37 active trials focusing on treatments like Enzalutamide, Trastuzumab emtansine (T-DM1), and PF-07220060. Nashville, Tennessee closely follows with 35 ongoing studies investigating similar interventions including Enzalutamide and Trastuzumab. Houston, Texas also demonstrates a commitment to advancing care for her2 positive breast cancer patients through their 31 active trials exploring Abemaciclib and Trastuzumab emtansine (T-DM1). New york City rounds out the list of top locations with 31 current studies investigating various treatments such as Imlunestrant and Abemaciclib. Finally, Denver, Colorado showcases its dedication to research by conducting 30 active trials examining innovative approaches like Entinostat and Therapeutic Conventional Surgery. These cities provide valuable opportunities for individuals battling her2 positive breast cancer to participate in cutting-edge clinical trials that may shape the future of treatment options.
Which are the top treatments for her2 positive breast cancer being explored in clinical trials?
The search for effective treatments for HER2 positive breast cancer is a dynamic and evolving field. Promising options currently being explored in clinical trials include:
- Abemaciclib, which is involved in 4 active trials and has been part of 65 all-time her2 positive breast cancer trials since its introduction in 2014.
- Trastuzumab, a well-established treatment with 4 ongoing trials and an impressive track record of 325 all-time her2 positive breast cancer trials since its initiation in 2000.
- Olaparib, another contender making strides with involvement in three active trials and having contributed to the findings of 50 all-time her2 positive breast cancer studies since it was listed as a potential option in 2010.
These innovative treatments hold promise for improving outcomes and quality of life for patients battling this aggressive form of breast cancer.
What are the most recent clinical trials for her2 positive breast cancer?
Recent clinical trials offer promising advancements in the treatment of HER2 positive breast cancer. Phase 2 studies have explored an initial regimen designed to improve outcomes for patients with this subtype of breast cancer. Additionally, a Phase 1 trial investigated the efficacy and safety of injections containing a high dose of viral particles as potential therapy for HER2 positive breast cancer. In Phase 3 trials, two different drugs—imlunestrant and elacestrant—were evaluated for their effectiveness against HER2 positive breast cancer. Moreover, denosumab was studied in a large-scale Phase 3 trial to assess its impact on this specific type of breast cancer. These recent clinical trials provide hope for improved treatment options and outcomes among those affected by HER2 positive breast cancer.
What her2 positive breast cancer clinical trials were recently completed?
Several clinical trials for HER2-positive breast cancer have recently concluded, showcasing the ongoing progress in finding effective treatments. In November 2021, G1 Therapeutics completed a trial investigating Trilaciclib's potential in combating this type of cancer. Concurrently, HiberCell wrapped up a trial exploring Pembrolizumab as a treatment option. Other noteworthy trials include Probiotic, sponsored by Mayo Clinic and completed in July 2021; Buzzy(R), sponsored by University of Wisconsin, Madison and finished in April 2021; LY3484356 from Eli Lilly and Company, also concluded in April 2021. These studies represent important strides forward in understanding and addressing HER2-positive breast cancer to ultimately improve patient outcomes.