Lee Ratner, MD, PhD | Division of ...

Dr. Lee Ratner, MD

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Washington University School of Medicine

Studies Kaposi's Sarcoma
Studies Kaposi Sarcoma
11 reported clinical trials
30 drugs studied

Affiliated Hospitals

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Washington University School Of Medicine

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Washington University

Clinical Trials Lee Ratner, MD is currently running

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Smoking Cessation Intervention

for HIV/AIDS

This clinical trial evaluates the usefulness of using a smartphone-based HIV-specific smoking cessation intervention at the time of lung cancer screening in helping people living with HIV quit smoking. Positively Smoke Free - Mobile may help patients with HIV quit smoking.

Recruiting

1 award

N/A

8 criteria

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Propranolol

for Kaposi Sarcoma

Kaposi sarcoma (KS) lesions are initiated by endothelial cells infected with KS herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8). Lesion progression is driven by abnormal angiogenesis, chronic inflammation, and uncontrolled cell proliferation. KS remains one of the most commonly diagnosed cancers in many African countries where economic constraints prevent successful treatment in most patients. Treatment outcomes in developed countries are also often unsatisfactory in HIV positive patients despite good virological and immunological responses to antiretroviral therapy. Therefore, identification of new oral, safe treatment options for treatment of KS remains a research priority. Given the known anti-angiogenic properties and based on the treatment response with other benign vascular lesions such as infantile hemangioma, propranolol is a good candidate for the treatment of KS. The hypothesis of this study is that treating patients with Kaposi sarcoma with propranolol will result in an overall response rate (complete response rate plus partial response rate) of at least 45%, and that propranolol will be safe and well tolerated in this patient population.

Recruiting

1 award

Phase 2

6 criteria

More about Lee Ratner, MD

Clinical Trial Related

4 years of experience running clinical trials · Led 11 trials as a Principal Investigator · 4 Active Clinical Trials

Treatments Lee Ratner, MD has experience with

  • Propranolol
  • Recombinant EphB4-HSA Fusion Protein
  • Smoking Cessation Intervention
  • Nicotine Replacement
  • Screening Tool
  • Non-Interventional Follow-up

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